Reactome | Ficolins bind to repetitive carbohydrate structures on the target cell surface

Ficolins bind to repetitive carbohydrate structures on the target cell surface

Stable Identifier

R-HSA-2855086

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Ficolins bind to repetitive carbohydrate structures on the target cell surface

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Ficolins are recognition molecules in the lectin pathway of complement activation. Three types of ficolin have been identified in humans: M-ficolin (ficolin-1, FCN1), L-ficolin (ficolin-2, FCN2) and H-ficolin (ficolin-3, FCN3). FCN2 and 3 circulate in blood plasma whereas FCN1 is locally secreted by immune response cells (Teh et al. 2000, Liu et al. 2005, Matsushita et al. 2002). Plasma ficolins circulate as complexes with MBL-associated serine proteases (MASPs). Upon binding of ficolins to carbohydrates on the target cell surface, MASPs are activated and subsequently activate the complement cascade (Matsushita et al. 2002, Gout et al. 2009). Ficolins function as trimers and larger oligomers. Ficolin peptide sequences contain an amino-terminal cysteine-rich region, a collagen-like domain, a neck region and a carboxy-terminal fibrinogen-like domain. The fibrinogen-like domain binds to pathogen- or apoptotic cell-associated molecular patterns. Different ficolins have distinct recognition specificities (Endo et al. 2007, Thiel and Gadjeva 2009, Garlatti et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
18406375	Ficolins: novel pattern recognition molecules of the innate immune response Männel, DN, Schwaeble, W, Runza, VL	Immunobiology	2008
20032467	Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin Martin, L, Arlaud, GJ, Dumestre-Pérard, C, Garlatti, V, Lacroix, M, Gaboriaud, C, Cesbron, JY, Thielens, NM, Lunardi, T, Smith, DF, Gout, E	J Biol Chem	2010
16116205	Human M-ficolin is a secretory protein that activates the lectin complement pathway Endo, Y, Nakata, M, Wada, I, Matsushita, M, Munakata, M, Liu, Y, Inoue, K, Fujita, T, Iwaki, D	J. Immunol.	2005
20375619	Structural insights into the recognition properties of human ficolins Martin, L, Thielens, NM, Garlatti, V, Lacroix, M, Gaboriaud, C, Arlaud, GJ, Gout, E	J Innate Immun	2010
11012776	M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-D-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli Le, Y, Lu, J, Teh, C, Lee, SH	Immunology	2000
17544822	Role of ficolin in innate immunity and its molecular basis Endo, Y, Matsushita, M, Fujita, T	Immunobiology	2007
11907111	Activation of the lectin complement pathway by H-ficolin (Hakata antigen) Kuraya, M, Matsushita, M, Tsujimura, M, Hamasaki, N, Shiraki, H, Fujita, T	J. Immunol.	2002
19799112	Humoral pattern recognition molecules: mannan-binding lectin and ficolins Gadjeva, M, Thiel, S	Adv. Exp. Med. Biol.	2009