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TREX1 dimer [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-3244607
Type
Complex
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
Regulation by TREX1 (Homo sapiens)
TREX1 binds retroviral-derived DNA (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
TREX1:viral DNA [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Viral DNA cleavage by TREX1 (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
TREX1:viral DNA [endoplasmic reticulum membrane] (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
STING recruits TBK1 and IRF3 (Homo sapiens)
TREX1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21937424
The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity
Perrino, FW
,
Hollis, T
,
Orebaugh, CD
,
Fye, JM
,
Harvey, S
J. Biol. Chem.
2011
Participants
components
x 2
TREX1 [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an input of
TREX1 binds retroviral-derived DNA (Homo sapiens)
as an output of
Viral DNA cleavage by TREX1 (Homo sapiens)
as a component of
TREX1:viral DNA [endoplasmic reticulum membrane] (Homo sapiens)
This entity regulates
Negatively
STING recruits TBK1 and IRF3
(Homo sapiens)
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