GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3341277
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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GPX2 (located in the gastrointestinal tract, also called GSHPx-GI, GPX-GI, and GI-GPx), like glutathione peroxidase 1 (GPX1, ubiquitous), reduces one molecule of hydrogen peroxide (H2O2) with two molecules of glutathione to yield one molecule of oxidized glutathione (glutathione disulfide, GSSG) and two molecules of water (Chu et al. 1998).
Literature References
PubMed ID Title Journal Year
8428933 Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI

Esworthy, RS, Chu, FF, Doroshow, JH

J Biol Chem 1993
Participants
Participates
Catalyst Activity

glutathione peroxidase activity of GPX2 tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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