Reactome | SLC6A18 transports Gly from extracellular region to cytosol

SLC6A18 transports Gly from extracellular region to cytosol

Stable Identifier

R-HSA-351963

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC6A18 transports Gly from extracellular region to cytosol

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The protein SLC6A18 was first identified as an amino acid transporter based on sequence similarity to other members of the SLC6 protein family (Hoglund et al. 2005). It is annotated here as mediating glycine uptake based on the phenotype of mice homozygous for a null mutation in the homologous gene (Quan et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
16125675	The repertoire of solute carriers of family 6: identification of new human and rodent genes Lindblom, J, Höglund, PJ, Scicluna, SJ, Fredriksson, R, Adzic, D	Biochem Biophys Res Commun	2005
15121838	Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2 Quan, H, Caron, MG, Wetsel, WC, Athirakul, K, Stevens, R, Torres, GE, Coffman, TM	Mol Cell Biol	2004