SLC25A10 mediates exchange of malate and phosphate

Stable Identifier
R-HSA-372843
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(S)-malate(in) + phosphate(out) => (S)-malate(out) + phosphate(in)
ReviewStatus
5/5
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SLC25A10, the mitochondrial dicarboxylate carrier protein in the inner mitochondrial membrane, mediates the reversible exchange of mitochondrial malate for cytosolic phosphate (Fiermonte et al. 1999). Mutations in the human SLC25A10 gene disrupt malate transport and are associated with severe clinical phenotypes (Punzi et al. 2018).
Literature References
PubMed ID Title Journal Year
10585886 Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family

Fiermonte, G, Dolce, V, Arrigoni, R, Walker, JE, Runswick, MJ, Palmieri, F

Biochem J 1999
29211846 SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency

Laera, L, Guerrini, R, Pierri, CL, Donati, MA, Ruggiu, M, Gorgoglione, R, Palmieri, L, Marobbio, CMT, Palmieri, F, Hossain, MF, Menga, A, Tiranti, V, Castegna, A, De Grassi, A, Scarcia, P, Lamantea, E, Lasorsa, FM, Giannattasio, S, Punzi, G, Ghezzi, D, Pisano, I, Paradies, E, Porcelli, V

Hum Mol Genet 2018
Participants
Participates
Catalyst Activity

dicarboxylic acid transmembrane transporter activity of SLC25A10 [mitochondrial inner membrane]

Orthologous Events
Cross References
Rhea
Authored
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