Reactome | SUMOylation of transcription cofactors

SUMOylation of transcription cofactors

Stable Identifier

R-HSA-3899300

DOI

10.3180/R-HSA-3899300.4

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SUMO1,2, and 3 are predominantly located in the nucleus and targets of SUMOylation are predominantly nuclear. Transcription cofactors are nuclear proteins that generally do not bind DNA themselves but interact with DNA-bound factors and influence transcription. SUMOylation of transcription cofactors usually inhibits the activity of the cofactor (reviewed in Girdwood et al. 2004, Gill 2005, Lyst and Stancheva 2007, Garcia-Dominguez and Reyes 2009). In the cases of coactivators such as PPARGC1A (PGC-1alpha) this results in decreased transcription; in the cases of corepressors such as MBD1 this results in increased transcription.

Literature References

PubMed ID	Title	Journal	Year
15209380	SUMO and transcriptional regulation Girdwood, DW, Tatham, MH, Hay, RT	Semin. Cell Dev. Biol.	2004
19616654	SUMO association with repressor complexes, emerging routes for transcriptional control Reyes, JC, Garcia-Dominguez, M	Biochim. Biophys. Acta	2009
16095902	Something about SUMO inhibits transcription Gill, G	Curr. Opin. Genet. Dev.	2005
18031228	A role for SUMO modification in transcriptional repression and activation Stancheva, I, Lyst, MJ	Biochem. Soc. Trans.	2007