Reactome | SUMOylation of intracellular receptors

SUMOylation of intracellular receptors

Stable Identifier

R-HSA-4090294

DOI

10.3180/R-HSA-4090294.2

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

At least 17 nuclear receptors have been discovered to be SUMOylated (reviewed in Treuter and Venteclef 2011, Wadosky et al. 2012, Knutson and Lange 2013). In all but a few cases (notably AR and RORA) SUMOylation causes transcriptional repression. Repression by SUMOylation is believed to occur through several mechanisms: interference with DNA binding, recruitment of corepressors, retention of corepressors at non-target promoters (transrepression), re-localization of nuclear receptors within the nucleus, interference with dimerization of receptors, and interference (crosstalk) with other post-translational modifications. SUMOylation of receptors affects inflammation and disease processes (Anbalagan et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23810010	Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation Lange, CA, Knutson, TP	Vitam. Horm.	2013
22037188	The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation Willis, MS, Wadosky, KM	Am. J. Physiol. Heart Circ. Physiol.	2012
21172431	Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation Venteclef, N, Treuter, E	Biochim. Biophys. Acta	2011
22438791	Post-translational modifications of nuclear receptors and human disease Rowan, BG, Murphy, L, Anbalagan, M, Huderson, B	Nucl Recept Signal	2012