HMIT co-transports myo-inositol with a proton

Stable Identifier
R-HSA-429101
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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HMIT co-transports myo-inositol with a proton
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SLC2A13 encodes a H+/myo-inositol co-transporter, HMIT (Uldry M et al, 2001) which is abundantly expressed in the brain. A proton is co-transported with myo-inositol uptake into cells. No glucose transport function has been detected to date.
Literature References
PubMed ID Title Journal Year
11500374 Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain

Horisberger, JD, Uldry, M, Thorens, B, Ibberson, M, Riederer, BM, Chatton, JY

EMBO J 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

myo-inositol:proton symporter activity of SLC2A13 [plasma membrane]

Physical Entity
SLC2A13 [plasma membrane] (Homo sapiens)
Activity
myo-inositol:proton symporter activity (GO:0005366)
Orthologous Events
HMIT co-transports myo-inositol with a proton (Bos taurus)
HMIT co-transports myo-inositol with a proton (Caenorhabditis elegans)
HMIT co-transports myo-inositol with a proton (Canis familiaris)
HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)
HMIT co-transports myo-inositol with a proton (Gallus gallus)
HMIT co-transports myo-inositol with a proton (Mus musculus)
HMIT co-transports myo-inositol with a proton (Rattus norvegicus)
HMIT co-transports myo-inositol with a proton (Saccharomyces cerevisiae)
HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)
HMIT co-transports myo-inositol with a proton (Sus scrofa)
HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2009-07-14)
Reviewed
He, L  (2009-08-24)
Created
Jassal, B  (2009-07-14)
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