CRAC translocates calcium from the extracellular region to the cytosol

Stable Identifier
R-HSA-434798
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Calcium influx via CRAC
ReviewStatus
5/5
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CRAC translocates calcium from the extracellular region to the cytosol
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Activation of Calcium-release-activated (CRAC) channels allows influx of calcium. The Orai component of CRAC is responsible for the selectivity of the channel, while the Stim component is responsible for activation.
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Catalyst Activity

store-operated calcium channel activity of CRAC channel [plasma membrane]

Physical Entity
CRAC channel [plasma membrane] (Homo sapiens)
Activity
store-operated calcium channel activity (GO:0015279)
Inferred From
Calcium influx via CRAC (Drosophila melanogaster)
Cross References
Rhea
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-09-02)
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