SLC41A1,2 transport Mg2+ from extracellular region to cytosol

Stable Identifier
R-HSA-442661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
MagT transporters mediate magnesium uptake into cells
ReviewStatus
5/5
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SLC41A1,2 transport Mg2+ from extracellular region to cytosol
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Magnesium (Mg2+) is an abundant cation that is important for many intracellular biochemical functions, especially as a cofactor for ATP. Intracellular Mg2+ concentrations must be finely regulated and recently, transporters for this cation have been elucidated. The human genes SLC41A1 and SLC41A2 encode magnesium transport proteins 1 and 2 respectively (MagT1 and MagT2). They both mediate the uptake of Mg2+ into cells (Goytain A and Quamme GA, 2005; Sahni J et al, 2007). A third human gene, SLC41A3, is also thought to encode a MagT protein but has not been characterized yet.
Literature References
PubMed ID Title Journal Year
16984228 SLC41A2 encodes a plasma-membrane Mg2+ transporter

Nelson, B, Sahni, J, Scharenberg, AM

Biochem J 2007
15804357 Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties

Quamme, GA, Goytain, A

BMC Genomics 2005
Participants
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Output
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as an event of
Catalyst Activity

magnesium ion transmembrane transporter activity of SLC41A1,2 [plasma membrane]

Physical Entity
SLC41A1,2 [plasma membrane] (Homo sapiens)
Activity
magnesium ion transmembrane transporter activity (GO:0015095)
Orthologous Events
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Bos taurus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Gallus gallus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)
SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2009-09-29)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-09-29)
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