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Smooth Muscle Contraction
Stable Identifier
R-HSA-445355
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
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Layers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac muscle. Smooth muscle is triggered to contract by the autonomic nervous system, hormones, autocrine/paracrine agents, local chemical signals, and changes in load or length.
Actin:myosin cross bridging is used to develop force with the influx of calcium ions (Ca2+) initiating contraction. Two separate protein pathways, both triggered by calcium influx contribute to contraction, a calmodulin driven kinase pathway, and a caldesmon driven pathway.
Recent evidence suggests that actin, myosin, and intermediate filaments may be far more volatile then previously suspected, and that changes in these cytoskeletal elements along with alterations of the focal adhesions that anchor these proteins may contribute to the contractile cycle.
Contraction in smooth muscle generally uses a variant of the same sliding filament model found in striated muscle, except in smooth muscle the actin and myosin filaments are anchored to focal adhesions, and dense bodies, spread over the surface of the smooth muscle cell. When actin and myosin move across one another focal adhesions are drawn towards dense bodies, effectively squeezing the cell into a smaller conformation. The sliding is triggered by calcium:caldesmon binding, caldesmon acting in an analogous fashion to troponin in striated muscle. Phosphorylation of myosin light chains also is involved in the initiation of an effective contraction.
Literature References
PubMed ID
Title
Journal
Year
14627618
Smooth muscle contraction and relaxation
Webb, RC
Adv Physiol Educ
2003
Participants
Events
ALDH2 transforms GTN to NO
(Homo sapiens)
NO binds to Guanylate Cyclase
(Homo sapiens)
sGC stimulators bind sGC:NO
(Homo sapiens)
Cinaciguat binds sGC:NO
(Homo sapiens)
Soluble guanylate cyclase converts GTP to cGMP
(Homo sapiens)
PDE5A dimer binds PDE5A inhibitors
(Homo sapiens)
T-type VDCC bind T-type VDCC blockers
(Homo sapiens)
Calcium binds calmodulin
(Homo sapiens)
MYLK (MLCK) Active Calmodulin Binding
(Homo sapiens)
Phosphorylation of Smooth Muscle Myosin Light Chains
(Homo sapiens)
Calcium Binds Caldesmon
(Homo sapiens)
Release Of ADP From Myosin
(Homo sapiens)
Myosin Binds ATP
(Homo sapiens)
ATP Hydrolysis By Myosin
(Homo sapiens)
DYSF, CAV3 and TRIM72 bind
(Homo sapiens)
CAV3:TRIM72:DYSF binds ANXAs
(Homo sapiens)
Participates
as an event of
Muscle contraction (Homo sapiens)
Event Information
Go Biological Process
muscle contraction (0006936)
Orthologous Events
Smooth Muscle Contraction (Bos taurus)
Smooth Muscle Contraction (Caenorhabditis elegans)
Smooth Muscle Contraction (Canis familiaris)
Smooth Muscle Contraction (Danio rerio)
Smooth Muscle Contraction (Dictyostelium discoideum)
Smooth Muscle Contraction (Drosophila melanogaster)
Smooth Muscle Contraction (Gallus gallus)
Smooth Muscle Contraction (Mus musculus)
Smooth Muscle Contraction (Rattus norvegicus)
Smooth Muscle Contraction (Saccharomyces cerevisiae)
Smooth Muscle Contraction (Schizosaccharomyces pombe)
Smooth Muscle Contraction (Sus scrofa)
Smooth Muscle Contraction (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000467
,
BIOMD0000000468
Authored
Gillespie, ME (2009-03-09)
Reviewed
Rush, MG (2008-01-11)
Created
Gillespie, ME (2009-10-30)
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