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N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
Stable Identifier
R-HSA-5099901
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD4 (Homo sapiens)
DVL2 is phosphorylated by PKC (Homo sapiens)
WNT5A:FZD4:DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
WNT5A binds FZD4 (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
WNT5A-FZD4 recruits DVL2 (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
WNT5A:FZD4:DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
WNT5A:FZD4 is endocytosed (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
ARRB bind GPCRs (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
Participants
components
FZD4 [plasma membrane]
(Homo sapiens)
N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome]
(Homo sapiens)
Participates
as an output of
WNT5A binds FZD4 (Homo sapiens)
as an input of
WNT5A-FZD4 recruits DVL2 (Homo sapiens)
as a component of
WNT5A:FZD4:DVL2 [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
WNT5A:FZD4:p-DVL2:ARRB2 [plasma membrane] (Homo sapiens)
Inferred To
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Bos taurus)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Caenorhabditis elegans)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Canis familiaris)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Drosophila melanogaster)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Gallus gallus)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Mus musculus)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Rattus norvegicus)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Sus scrofa)
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
(Xenopus tropicalis)
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