Reactome | VEGFR2 mediated cell proliferation

VEGFR2 mediated cell proliferation

Stable Identifier

R-HSA-5218921

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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VEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf/MEK/ERK pathway. PKC alpha can intersect the Ras/Raf/MEK/ERK cascade at the level of Ras (Clark et al. 2004) or downstream of Ras through direct phosphorylation of Raf (Kolch et al. 1993). VEGF stimulation leads to Ras activation in a Ras-guanine nucleotide exchange factor (GEF) independent mechanism. It rather relies on modulating the regulation of Ras-GTPase activating protein (GAP) than regulation of Ras-GEFS (Wu et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
22866201	Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies Shibuya, M	Genes Cancer	2011
22180219	The reception and the party after: how vascular endothelial growth factor receptor 2 explores cytoplasmic space Berger, P, Ballmer-Hofer, K	Swiss Med Wkly	2011
22762016	Signal transduction by vascular endothelial growth factor receptors Koch, S, Claesson-Welsh, L	Cold Spring Harb Perspect Med	2012