GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

Stable Identifier
R-HSA-5694071
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GLO1 dimer:2xZn2+ trnasforms glutathione and methylglyoxal to lactoylglutathione
ReviewStatus
5/5
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GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH
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Lactoylglutathione lyase (GLO1) catalyses the transformation of methylglyoxal (MGXL) and glutathione (GSH) to (R)-S-lactoylglutathione ((R)-S-LGSH), an intermediate in pyruvate metabolism. MGXL is a reactive 2-oxoaldehyde byproduct of normal metabolism that is a carcinogen and a mutagen (Ridderstrom et al. 1998). This is the first step in the glyoxalase system, a critical two-step detoxification system for MGXL.
Literature References
PubMed ID Title Journal Year
9705294 Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I

Jones, TA, Mannervik, B, Cameron, AD, Ridderström, M

J. Biol. Chem. 1998
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Event Information
Go Biological Process
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione (0019243)
Catalyst Activity

lactoylglutathione lyase activity of GLO1 dimer:2xZn2+ [cytosol]

Physical Entity
GLO1 dimer:2xZn2+ [cytosol] (Homo sapiens)
Activity
lactoylglutathione lyase activity (GO:0004462)
Orthologous Events
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Bos taurus)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Drosophila melanogaster)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Gallus gallus)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Mus musculus)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Plasmodium falciparum)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Rattus norvegicus)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Saccharomyces cerevisiae)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Schizosaccharomyces pombe)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Sus scrofa)
GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-05-21)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-21)
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