GDP-fucose biosynthesis

Stable Identifier
R-HSA-6787639
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Fucose-containing glycans play important roles in immunity and signalling. Fucosylated glycans are created by fucosyltransferases, which require the high-energy donor substrate GDP-fucose. Two pathways for the synthesis of GDP-fucose exist in mammalian cells; the GDP-mannose-dependent de novo pathway provides the majority of GDP-fucose whereas a minor contribution comes from the free fucose-dependent salvage pathway (Becker & Lowe 2003).
Literature References
PubMed ID Title Journal Year
12651883 Fucose: biosynthesis and biological function in mammals

Lowe, JB, Becker, DJ

Glycobiology 2003
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