IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane]

Stable Identifier
R-HSA-6809138
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IL35:IL12RB2:JAK2:gp130:JAK2
Locations in the PathwayBrowser
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General
Interleukin-35(IL-35) ,a heterodimer composed by Interleukin-12 subunit beta and Interleukin-27 subunit alpha, signals through IL-12R beta2(IL12RB2) and Interleukin-27 receptor alpha(IL-27RA) in B cells, activating signal transducer and activator of transcription 1(STAT1) and signal transducer and activator of transcription 3(STAT3).
Literature References
PubMed ID Title Journal Year
24743305 Interleukin-35 induces regulatory B cells that suppress autoimmune disease

Kim, SH, Wingfield, PT, Mahdi, RM, Dambuza, IM, Yu, CR, Wang, RX, Sergeev, YV, Egwuagu, CE, Dolinska, MB

Nat. Med. 2014
Participants
components
Participates
as an output of
as an input of
Inferred To
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Bos taurus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Canis familiaris)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Gallus gallus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Mus musculus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Rattus norvegicus)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Sus scrofa)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Xenopus tropicalis)
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