4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+

Stable Identifier
R-HSA-70906
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic imidazolonepropionase catalyzes the hydrolysis of 4-imidazolone-5-propanoate to form N-Formimino-L-glutamate. While evidence from many experimental systems indicates that this reaction occurs, existence of the human enzyme is inferred only from high-throughput screening studies (e.g., Yamada et al. 2004).
Literature References
PubMed ID Title Journal Year
15221005 Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas

Kaneko, M, Yamada, S, Ohnuma, N, Suita, S, Suzuki, Y, Hirata, T, Nakagawara, A, Horie, H, Ando, H, Ando, K, Sasaki, F, Hayashi, Y, Sugano, S, Goto, T, Takayasu, H, Ohira, M, Matsunaga, T, Hashizume, K, Hiyama, E

Oncogene 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides of AMDHD1 [cytosol]

Physical Entity
AMDHD1 [cytosol] (Homo sapiens)
Activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides (GO:0016812)
Orthologous Events
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Gallus gallus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2003-06-24)
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