Reactome | DHAP is converted to G3P by GPD1/GPD1L

DHAP is converted to G3P by GPD1/GPD1L

Stable Identifier

R-HSA-75889

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate

ReviewStatus

5/5

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Dihydroxyacetone phosphate (DHAP) is converted to glycerol-3-phosphate (G3P) by glycerol-3-phosphate dehydrogenase (GPD1) or by glycerol-3-phosphate dehydrogenase-like (GPD1L) enzymes (Ou et al. 2006, Valdivia et al. 2009). The active forms of both enzymes are homodimers. This reaction may be found in white adipose tissues where glycerol-3-kinase activity is not observed in sufficient levels. GPD1/GPD1L reduces dihydroxyacetone phosphate with NADH donating electrons to this reduction.

Literature References

PubMed ID	Title	Journal	Year
16460752	Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1) Bartlam, M, Li, X, Rao, Z, Wong, LL, Zhao, X, Mao, Y, Ji, C, Han, X, Ou, X	J Mol Biol	2006
19666841	GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A Makielski, JC, Valdivia, CR, Ueda, K, Ackerman, MJ	Am J Physiol Heart Circ Physiol	2009