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Transport of fatty acids
Stable Identifier
R-HSA-804914
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Transport of fatty acids (Homo sapiens)
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Long chain fatty acids (LCFAs) are involved in many cellular functions. They can be used as an important source of energy by skeletal muscle and heart tissues. Also, they are used in the production of hormones which can regulate inflammation, blood pressure, the clotting process, blood lipid levels and the immune response. Fatty acid transporter proteins (FATPs) are a family of proteins which mediate fatty acid uptake into cells when overexpressed. FATPs also possess enzymatic activity, the details of which are captured elsewhere. There are 6 human genes of the SLC27A family which encode for FATP1-6 (Stahl A, 2004; Gimeno RE, 2007). To date, only FATP1, 4 and 6 have demonstrable transporter function. Fatty acids with carbon chain lengths of more than 10 are the most likely substrates for these transporters.
Literature References
PubMed ID
Title
Journal
Year
17495600
Fatty acid transport proteins
Gimeno, RE
Curr Opin Lipidol
2007
12856180
A current review of fatty acid transport proteins (SLC27)
Stahl, A
Pflugers Arch
2004
Participants
Events
SLC27A1,4,6 transport LCFAs from extracellular region to cytosol
(Homo sapiens)
LCNs bind lipids
(Homo sapiens)
Participates
as an event of
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Event Information
Go Biological Process
long-chain fatty acid transport (0015909)
Orthologous Events
Transport of fatty acids (Bos taurus)
Transport of fatty acids (Caenorhabditis elegans)
Transport of fatty acids (Canis familiaris)
Transport of fatty acids (Danio rerio)
Transport of fatty acids (Drosophila melanogaster)
Transport of fatty acids (Gallus gallus)
Transport of fatty acids (Mus musculus)
Transport of fatty acids (Rattus norvegicus)
Transport of fatty acids (Saccharomyces cerevisiae)
Transport of fatty acids (Sus scrofa)
Transport of fatty acids (Xenopus tropicalis)
Authored
Jassal, B (2010-05-26)
Reviewed
He, L (2010-07-07)
Created
Jassal, B (2010-05-26)
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