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LDL [lysosomal lumen]
Stable Identifier
R-HSA-8876367
Type
Complex
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
low-density lipoprotein complex
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)
LDL [lysosomal lumen] (Homo sapiens)
LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)
LDL [lysosomal lumen] (Homo sapiens)
General
LDL (low density lipoproteins) are complexes of a single molecule of apoprotein B-100 (apoB-100) non-covalently associated with triacylglycerol, free cholesterol, cholesterol esters, and phospholipids. LDL complexes contain single molecules of apoB-100, but their content of lipids is variable (Chapman et al. 1988; Mateu et al. 1972; Tardieu et al. 1976). High levels of LDL in the blood are strongly correlated with increased risk of atherosclerosis, and recent studies have raised the possibility that this risk is further increased in individuals whose blood LDL population is enriched in high-density (low lipid content) LDL complexes (Rizzo and Berneis 2006). The LDL complex annotated here contains an average lipid composition.
Participants
components
APOB(28-4563) [lysosomal lumen]
(Homo sapiens)
x 670
CHOL [lysosomal lumen]
x 1500
cholesterol esters [lysosomal lumen]
x 690
PL [lysosomal lumen]
x 170
TAGs [lysosomal lumen]
Participates
as an output of
LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)
as an input of
LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)
Inferred To
LDL [lysosomal lumen]
(Bos taurus)
LDL [lysosomal lumen]
(Canis familiaris)
LDL [lysosomal lumen]
(Gallus gallus)
LDL [lysosomal lumen]
(Mus musculus)
LDL [lysosomal lumen]
(Rattus norvegicus)
LDL [lysosomal lumen]
(Sus scrofa)
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