Reactome | Chylomicron assembly

Chylomicron assembly

Stable Identifier

R-HSA-8963888

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Chylomicrons transport triacylglycerol, phospholipid, and cholesterol derived from dietary lipid from the small intestine to other tissues of the body. Each chylomicron assembles around a single molecule of apolipoprotein B-48 (Phillips et al. 1997) which at the time the particle leaves the intestine and enters the lymphatic circulation is complexed with >200,000 molecules of triacylglycerol (TG), ~35,000 of phospholipid, ~11,000 of cholesterol ester, ~8,000 of free cholesterol, ~60 copies of apolipoprotein A-I, ~15 copies of apolipoprotein A-IV, and copies of apolipoprotein A-II (Bhattacharya and Redgrave 1981).

Literature References

PubMed ID	Title	Journal	Year
7288288	The content of apolipoprotein B in chylomicron particles Redgrave, TG, Bhattacharya, S	J Lipid Res	1981
9215545	A single copy of apolipoprotein B-48 is present on the human chylomicron remnant Gutierrez, MM, Phillips, ML, Chen, G, Kroes, J, Kroes, I, Schumaker, VN, Pullinger, C, Curtiss, LK, Hardman, DA, Kane, JP	J Lipid Res	1997