Reactome | GLRA:GLRB:Gly transports extracellular Cl- to cytosol

GLRA:GLRB:Gly transports extracellular Cl- to cytosol

Stable Identifier

R-HSA-975389

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

The glycine receptor complex is permeable to Cl- when glycine binds to it

ReviewStatus

5/5

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GLRA:GLRB:Gly transports extracellular Cl- to cytosol

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The glycine receptor (GLR) is a ligand-gated ion channel. It is functional as a heteropentamer, consisting of alpha (GLRA) and beta (GLRB) subunits. With no ligand bound, the receptor complex is closed to chloride ions. Binding of the inhibitory neurotransmitter glycine (Gly) to this receptor complex increases chloride conductance into neurons and thus produces hyperpolarization (inhibition of neuronal firing) (Grenningloh et al. 1990, Nikolic et al. 1998, Handford et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
2155780	Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes Becker, CM, Grenningloh, G, Schofield, PR, Betz, H, Siddique, T, Schmieden, V, Mohandas, TK, Seeburg, PH	EMBO J	1990
9677400	The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts Becker, CM, Poustka, A, Laube, B, Nikolic, Z, Lichter, P, Mülhardt, C, Weber, RG, Kioschis, P	J Biol Chem	1998
8717357	The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes Baker, E, Schofield, PR, Sutherland, GR, Handford, CA, Ford, JH, Webb, GC, Lynch, JW	Brain Res Mol Brain Res	1996