Trehalose-6-phosphate is hydrolyzed to trehalose

Stable Identifier
R-MTU-868608
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
ReviewStatus
5/5
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Hydrolysis of trehalose phosphate, catalyzed by OtsB2, gives trehalose. The enzyme needs magnesium for its activity. A second homologue, OtsB1 is non-functional (De Smet et al, 2000; Edavana et al, 2004).
Literature References
PubMed ID Title Journal Year
10658666 Three pathways for trehalose biosynthesis in mycobacteria

Young, DB, De Smet, KA, Robertson, BD, Brown, IN, Weston, A

Microbiology 2000
15158675 Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis

Elbein, AD, Edavana, VK, Carroll, JD, Abraham, EC, Pastuszak, I, Thampi, P

Arch Biochem Biophys 2004
Participants
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Catalyst Activity

trehalose-phosphatase activity of OtsB-Mg2+ [cytosol]

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