trehalose + H2O => 2 D-glucose

Stable Identifier
R-OCU-189019
Type
Reaction [transition]
Species
Oryctolagus cuniculus
Compartment
extracellular region, plasma membrane
Synonyms
Digestion of trehalose to yield glucose
ReviewStatus
5/5
General
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trehalose + H2O => 2 D-glucose
Extracellular trehalose, a disaccharide, is cleaved by trehalase associated with the plasma membrane to yield two molecules of glucose. Trehalase has been purified to homogeneity from rabbit intestine and shown to be a monomer attached to the plasma membrane by a GPI anchor (Galand 1984; Ruf et al. 1990). A human cDNA encoding a closely homologous protein has been cloned and its protein product has been shown to have trehalase activity in vitro (Ishihara et al. 1997). The human enzyme has not been characterized further, and so both the posttranslational modifications of the human enzyme and its activity in vivo have been inferred from the properties of the well studied rabbit enzyme.

Trehalase deficiency has been described in two isolated cases in Europe (Bergoz 1971; Madzarovovà-Nohejlova 1973) and at high frequency in a population of Greenland natives (Gudmand-Hoyer et al. 1988) but molecular defects responsible for the deficiency have not yet been described so it is not annotated in Reactome.

Literature References
PubMed ID Title Journal Year
1697585 Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring.

von Kieckebusch, A, Mantei, N, Semenza, G, James, P, Ruf, J, Galand, G, Wacker, H, Maffia, M, Seiler, P

J Biol Chem 1990
6466686 Purification and characterization of kidney and intestinal brush-border membrane trehalases from the rabbit

Galand, G

Biochim Biophys Acta 1984
Participants
Input
Output
Catalyst Activity

alpha,alpha-trehalase activity of trehalase [plasma membrane]

Physical Entity
trehalase [plasma membrane] (Oryctolagus cuniculus)
Activity
alpha,alpha-trehalase activity (GO:0004555)
Orthologous Events
trehalose + H2O => 2 D-glucose (Homo sapiens)
Authored
D'Eustachio, P  (2006-11-03)
Reviewed
Nichols, BL  (2007-01-16)
Created
D'Eustachio, P  (2006-11-03)
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