Symbol:
Ctbp1
Name:
C-terminal binding protein 1
RGD ID:
2441
Description:
Enables NAD binding activity; PDZ domain binding activity; and protein homodimerization activity. Involved in presynapse to nucleus signaling pathway. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is extrinsic component of presynaptic endocytic zone membrane. Orthologous to human CTBP1 (C-terminal binding protein 1); PARTICIPATES IN Notch signaling pathway; chronic myeloid leukemia pathway; Notch signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
50 kDa BFA-dependent ADP-ribosylation substrate; 50-kDa BFA-induced ADP-ribosylated substrate; 50-kDaBFA-inducedADP-ribosylatedsubstrate; BARS; BARS-50; brefeldin A-ADP-riboslyated substrate; C-terminal-binding protein 1; C-terminal-binding protein 3; C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate; ctBP3; CtBP3/BARS; MGC93318
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 14 81,679,956 - 81,707,331 (+) NCBI GRCr8 mRatBN7.2 14 77,455,580 - 77,482,821 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 14 77,455,696 - 77,482,821 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 14 81,897,623 - 81,924,823 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 14 83,138,172 - 83,165,372 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 14 79,583,490 - 79,610,690 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 14 82,762,109 - 82,789,350 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 82,762,190 - 82,789,319 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 14 83,447,911 - 83,475,152 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 83,022,824 - 83,050,335 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 14 83,025,214 - 83,052,726 (-) NCBI Celera 14 76,376,169 - 76,398,029 (+) NCBI Celera Cytogenetic Map 14 q21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - KEGG (archival)
Imported Annotations - PID (archival)
Biological Process
cell differentiation (IEA) membrane fusion (TAS) negative regulation of DNA-templated transcription (IEA,ISO,ISS) negative regulation of transcription by RNA polymerase II (IEA,ISO) Notch signaling pathway (IEA,ISO) positive regulation of DNA-templated transcription (IEA) presynapse to nucleus signaling pathway (IDA,IMP) regulation of cell cycle (IEA,ISO) regulation of transcription by RNA polymerase II (IBA) synaptic vesicle clustering (IEA,ISO) synaptic vesicle endocytosis (IEA,ISO) white fat cell differentiation (IEA,ISO,ISS)
Cellular Component
cytoplasm (IEA,IMP) extrinsic component of presynaptic endocytic zone membrane (IDA) GABA-ergic synapse (IEA,ISO) glutamatergic synapse (IDA,IEA,IMP,ISO) neuron projection (IEA) nucleoplasm (IEA,ISO) nucleus (IBA,IEA,IMP,ISO,ISS) presynaptic active zone cytoplasmic component (IEA,ISO) synapse (IEA) transcription repressor complex (IEA,ISO,ISS)
Molecular Function
acyltransferase activity (TAS) chromatin binding (IEA,ISO) DNA-binding transcription factor binding (IBA,IEA,ISO) identical protein binding (IEA,ISO) lncRNA binding (IEA,ISO) NAD binding (IDA,IEA,ISO) oxidoreductase activity (IEA) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA,ISO,ISS) PDZ domain binding (IPI) protein binding (IPI,ISO) protein domain specific binding (IEA,ISO) protein homodimerization activity (IPI) RNA polymerase II-specific DNA-binding transcription factor binding (IEA,ISO) transcription coactivator activity (IBA) transcription coregulator binding (IBA) transcription corepressor activity (IBA,IEA,ISO,TAS) transcription corepressor binding (IEA,ISO)
1.
Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain.
Belgrader P, etal., J Biol Chem 1991 May 25;266(15):9893-9.
2.
CtBP, an unconventional transcriptional corepressor in development and oncogenesis.
Chinnadurai G Mol Cell 2002 Feb;9(2):213-24.
3.
Evidence that the 50-kDa substrate of brefeldin A-dependent ADP-ribosylation binds GTP and is modulated by the G-protein beta gamma subunit complex.
Di Girolamo M, etal., Proc Natl Acad Sci U S A 1995 Jul 18;92(15):7065-9.
4.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.
Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
6.
Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP).
Hickabottom M, etal., J Biol Chem 2002 Dec 6;277(49):47197-204. Epub 2002 Oct 7.
7.
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, etal., Cell Rep. 2020 Feb 18;30(7):2444-2459.e7. doi: 10.1016/j.celrep.2020.01.079.
8.
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, etal., EMBO J. 2015 Apr 15;34(8):1056-77. doi: 10.15252/embj.201488796. Epub 2015 Feb 4.
9.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
10.
CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization.
Nardini M, etal., Biochem Biophys Res Commun. 2009 Mar 27;381(1):70-4. doi: 10.1016/j.bbrc.2009.02.010. Epub 2009 Feb 10.
11.
CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission.
Nardini M, etal., EMBO J 2003 Jun 16;22(12):3122-30.
12.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
14.
PID Annotation Import Pipeline
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15.
Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins.
Quinlan KG, etal., Mol Cell Biol. 2006 Nov;26(21):8159-72. Epub 2006 Aug 28.
16.
GOA pipeline
RGD automated data pipeline
17.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
18.
Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS.
Riefler GM and Firestein BL, J Biol Chem. 2001 Dec 21;276(51):48262-8. Epub 2001 Oct 5.
19.
Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure.
Spano S, etal., J Biol Chem 1999 Jun 18;274(25):17705-10.
20.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21.
Tentative Sequence Identification Numbers
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Ctbp1 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 14 81,679,956 - 81,707,331 (+) NCBI GRCr8 mRatBN7.2 14 77,455,580 - 77,482,821 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 14 77,455,696 - 77,482,821 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 14 81,897,623 - 81,924,823 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 14 83,138,172 - 83,165,372 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 14 79,583,490 - 79,610,690 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 14 82,762,109 - 82,789,350 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 82,762,190 - 82,789,319 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 14 83,447,911 - 83,475,152 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 83,022,824 - 83,050,335 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 14 83,025,214 - 83,052,726 (-) NCBI Celera 14 76,376,169 - 76,398,029 (+) NCBI Celera Cytogenetic Map 14 q21 NCBI
CTBP1 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 4 1,211,445 - 1,250,355 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 4 1,211,445 - 1,250,333 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 4 1,205,233 - 1,244,143 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 4 1,195,228 - 1,232,908 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 4 1,195,117 - 1,232,621 NCBI Celera 4 1,138,238 - 1,175,924 (-) NCBI Celera Cytogenetic Map 4 p16.3 NCBI HuRef 4 1,173,813 - 1,211,667 (-) NCBI HuRef CHM1_1 4 1,204,881 - 1,242,708 (-) NCBI CHM1_1 T2T-CHM13v2.0 4 1,210,608 - 1,249,282 (-) NCBI T2T-CHM13v2.0
Ctbp1 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 5 33,405,067 - 33,432,348 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 5 33,405,067 - 33,432,338 (-) Ensembl GRCm39 Ensembl GRCm38 5 33,247,723 - 33,275,004 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 5 33,247,723 - 33,274,994 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 5 33,590,372 - 33,617,618 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 5 33,564,580 - 33,591,826 (-) NCBI MGSCv36 mm8 Celera 5 30,726,910 - 30,746,219 (-) NCBI Celera Cytogenetic Map 5 B1 NCBI cM Map 5 17.52 NCBI
Ctbp1 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955514 626,645 - 652,817 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955514 630,168 - 652,817 (-) NCBI ChiLan1.0 ChiLan1.0
CTBP1 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 3 1,542,985 - 1,581,765 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 4 1,509,137 - 1,547,666 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 4 1,354,806 - 1,393,244 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 4 1,238,982 - 1,275,536 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 4 1,238,984 - 1,266,822 (-) Ensembl panpan1.1 panPan2
CTBP1 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 3 91,385,733 - 91,400,252 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 3 91,379,049 - 91,400,656 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 3 93,843,707 - 93,867,009 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 3 92,375,018 - 92,398,321 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 3 92,374,989 - 92,398,326 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 3 91,548,411 - 91,571,713 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 3 91,601,300 - 91,624,692 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 3 91,985,325 - 92,008,625 (+) NCBI UU_Cfam_GSD_1.0
Ctbp1 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024405285 68,331,034 - 68,353,468 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936477 22,032,664 - 22,055,187 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936477 22,032,712 - 22,055,160 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
CTBP1
CTBP1 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 27 47,533,490 - 47,570,505 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 27 47,544,682 - 47,570,636 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666051 3,909,688 - 3,946,439 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Ctbp1
.
Predicted Target Of
Count of predictions: 676 Count of miRNA genes: 286 Interacting mature miRNAs: 353 Transcripts: ENSRNOT00000057929, ENSRNOT00000065393 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
2313089 Bss81 Bone structure and strength QTL 81 3.4 0.0001 body length (VT:0001256) body length, nose to rump (CMO:0000079) 14 37669719 82669719 Rat 9590294 Uminl4 Urine mineral level QTL 4 5.66 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 14 55624247 100624247 Rat 1582236 Gluco22 Glucose level QTL 22 3.3 0.0164 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 14 73415323 92554092 Rat 2300197 Scl59 Serum cholesterol level QTL 59 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 14 55147478 100147478 Rat 70153 Bp59 Blood pressure QTL 59 3.2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 14 68757796 83368335 Rat 70187 Pancm5 Pancreatic morphology QTL 5 16.7 pancreas mass (VT:0010144) pancreas weight to body weight ratio (CMO:0000630) 14 30320092 80829842 Rat 631523 Pia13 Pristane induced arthritis QTL 13 3.3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 14 40793460 98037301 Rat 1582259 Gluco23 Glucose level QTL 23 3.1 0.0008 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 14 70053989 104886043 Rat 1582197 Gluco27 Glucose level QTL 27 3.4 0.0006 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 14 73415323 92554092 Rat 2313100 Bss82 Bone structure and strength QTL 82 3 0.0001 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) 14 37669719 82669719 Rat 634328 Hc5 Hypercalciuria QTL 5 2.3 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) 14 58184885 103184885 Rat 1582250 Gluco26 Glucose level QTL 26 3.3 0.0009 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 14 73415323 95876975 Rat 2317879 Alcrsp27 Alcohol response QTL 27 3.3 0.63 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 14 56631369 101631369 Rat 1641900 Alcrsp11 Alcohol response QTL 11 alcohol metabolism trait (VT:0015089) blood ethanol level (CMO:0000535) 14 70053989 104886043 Rat 631839 Niddm37 Non-insulin dependent diabetes mellitus QTL 37 3.37 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 14 11030622 95876975 Rat 1582255 Gluco29 Glucose level QTL 29 3.1 0.0025 blood glucose amount (VT:0000188) absolute change in blood glucose level area under curve (CMO:0002034) 14 73415323 92554092 Rat 9589034 Epfw11 Epididymal fat weight QTL 11 6 0.001 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 14 55624247 100624247 Rat 1582209 Gluco20 Glucose level QTL 20 3.8 0.0005 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 14 73415323 92554092 Rat 2313048 Bss84 Bone structure and strength QTL 84 3.1 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 14 37669719 82669719 Rat 1300136 Rf22 Renal function QTL 22 3.9 renal blood flow trait (VT:2000006) absolute change in renal vascular resistance (CMO:0001900) 14 42262529 95023211 Rat 1549834 Scl45 Serum cholesterol level QTL 45 5.8 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 14 50023211 95023211 Rat 738037 Hcas6 Hepatocarcinoma susceptibility QTL 6 2.93 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) 14 39057237 83368335 Rat 2313084 Bss83 Bone structure and strength QTL 83 2.9 0.0001 tibia size trait (VT:0100001) tibia midshaft endosteal cross-sectional area (CMO:0001716) 14 37669719 82669719 Rat
RH128943
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 14 77,482,626 - 77,482,820 (+) MAPPER mRatBN7.2 Rnor_6.0 14 82,789,156 - 82,789,349 NCBI Rnor6.0 Rnor_5.0 14 83,474,958 - 83,475,151 UniSTS Rnor5.0 RGSC_v3.4 14 83,022,792 - 83,022,985 UniSTS RGSC3.4 Celera 14 76,397,868 - 76,398,061 UniSTS Cytogenetic Map 14 q21 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000057929 ⟹ ENSRNOP00000054738
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 14 77,455,696 - 77,482,286 (+) Ensembl Rnor_6.0 Ensembl 14 82,762,190 - 82,788,736 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000065393 ⟹ ENSRNOP00000062945
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 14 77,455,742 - 77,482,821 (+) Ensembl Rnor_6.0 Ensembl 14 82,769,642 - 82,789,319 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000112665 ⟹ ENSRNOP00000080240
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 14 77,455,696 - 77,482,821 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000119292 ⟹ ENSRNOP00000081185
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 14 77,455,696 - 77,482,821 (+) Ensembl
RefSeq Acc Id:
NM_019201 ⟹ NP_062074
RefSeq Status:
PROVISIONAL
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,680,096 - 81,707,298 (+) NCBI mRatBN7.2 14 77,455,586 - 77,482,788 (+) NCBI Rnor_6.0 14 82,762,115 - 82,789,317 (+) NCBI Rnor_5.0 14 83,447,911 - 83,475,152 (+) NCBI RGSC_v3.4 14 83,022,824 - 83,050,335 (-) RGD Celera 14 76,376,169 - 76,398,029 (+) RGD
Sequence:
GCGCGGCTGGCGGCGCGGTGGCGGCTCGGCACGGCGGTGGCCGGTCGCAGGCGGCCGGGCGGAATAGCAGACTGCGCCGAAGCCGCCCCAGGCGCAGGGCTCGCGGCGGCGGAGAGCGCCGGACTCAT
hide sequence
RefSeq Acc Id:
XM_006251225 ⟹ XP_006251287
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,679,956 - 81,707,331 (+) NCBI mRatBN7.2 14 77,455,582 - 77,482,821 (+) NCBI Rnor_6.0 14 82,762,145 - 82,789,350 (+) NCBI Rnor_5.0 14 83,447,911 - 83,475,152 (+) NCBI
Sequence:
ACGGCGGTGGCCGGTCGCAGGCGGCCGGGCGGAATAGCAGACTGCGCCGAAGCCGCCCCAGGCGCAGGGCTCGCGGCGGCGGAGAGCGCCGGACTCATCGGGGCCCGCGGCCACCCGCGCCTTTCAAT
hide sequence
RefSeq Acc Id:
XM_006251226 ⟹ XP_006251288
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,679,956 - 81,707,331 (+) NCBI mRatBN7.2 14 77,455,581 - 77,482,821 (+) NCBI Rnor_6.0 14 82,762,144 - 82,789,350 (+) NCBI Rnor_5.0 14 83,447,911 - 83,475,152 (+) NCBI
Sequence:
CACGGCGGTGGCCGGTCGCAGGCGGCCGGGCGGAATAGCAGACTGCGCCGAAGCCGCCCCAGGC
hide sequence
RefSeq Acc Id:
XM_006251227 ⟹ XP_006251289
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,679,956 - 81,707,331 (+) NCBI mRatBN7.2 14 77,455,582 - 77,482,821 (+) NCBI Rnor_6.0 14 82,762,145 - 82,789,350 (+) NCBI Rnor_5.0 14 83,447,911 - 83,475,152 (+) NCBI
Sequence:
ACGGCGGTGGCCGGTCGCAGGCGGCCGGGCGGAATAGCAGACTGCGCCGAAGCCGCCCCAGGCGCAGGGCTCGCGGCGGCGGAGAGCGCCGGACTCATCGGGGCCCGCGGCCACCCGCGCCTTTCAAT
hide sequence
RefSeq Acc Id:
XM_006251228 ⟹ XP_006251290
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,679,956 - 81,707,331 (+) NCBI mRatBN7.2 14 77,455,581 - 77,482,821 (+) NCBI Rnor_6.0 14 82,762,145 - 82,788,630 (+) NCBI Rnor_5.0 14 83,447,911 - 83,475,152 (+) NCBI
Sequence:
ACGGCGGTGGCCGGTCGCAGGCGGCCGGGCGGAATAGCAGACTGCGCCGAAGCCGCCCCAGGCGCAGGGCTCGCGGCGGCGGAGAGCGCCGGACTCATCGGGGCCCGCGGCCACCCGCGCCTTTCAAT
hide sequence
RefSeq Acc Id:
XM_017599147 ⟹ XP_017454636
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,680,403 - 81,707,331 (+) NCBI mRatBN7.2 14 77,455,975 - 77,482,821 (+) NCBI Rnor_6.0 14 82,762,450 - 82,789,350 (+) NCBI
Sequence:
TGCGCATGCGCGAACTGCTGTACAGGCGTGCGCGTGCGTGTGCGCGTCCCTATTTTCCGCTGCC
hide sequence
RefSeq Acc Id:
XM_063272993 ⟹ XP_063129063
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,682,301 - 81,707,331 (+) NCBI
RefSeq Acc Id:
XM_063272994 ⟹ XP_063129064
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,680,416 - 81,707,331 (+) NCBI
RefSeq Acc Id:
XM_063272996 ⟹ XP_063129066
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,682,340 - 81,707,331 (+) NCBI
RefSeq Acc Id:
XM_063272997 ⟹ XP_063129067
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,680,417 - 81,707,331 (+) NCBI
RefSeq Acc Id:
XM_063272998 ⟹ XP_063129068
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 14 81,680,416 - 81,707,331 (+) NCBI
RefSeq Acc Id:
NP_062074 ⟸ NM_019201
- UniProtKB:
Q9Z2F5 (UniProtKB/Swiss-Prot), A6IK67 (UniProtKB/TrEMBL), A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
MSGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNL
hide sequence
RefSeq Acc Id:
XP_006251287 ⟸ XM_006251225
- Peptide Label:
isoform X1
- UniProtKB:
A0A0H2UI20 (UniProtKB/TrEMBL), A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
MGSSHLLNKGLPLGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHE
hide sequence
RefSeq Acc Id:
XP_006251289 ⟸ XM_006251227
- Peptide Label:
isoform X5
- UniProtKB:
A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
MGSSHLLNKGLPLGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEET
hide sequence
RefSeq Acc Id:
XP_006251288 ⟸ XM_006251226
- Peptide Label:
isoform X2
- UniProtKB:
A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
MGSSHLLNKGLPLGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHE
hide sequence
RefSeq Acc Id:
XP_006251290 ⟸ XM_006251228
- Peptide Label:
isoform X6
- UniProtKB:
A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
MGSSHLLNKGLPLGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEET
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RefSeq Acc Id:
XP_017454636 ⟸ XM_017599147
- Peptide Label:
isoform X3
- UniProtKB:
Q9Z2F5 (UniProtKB/Swiss-Prot), A6IK67 (UniProtKB/TrEMBL), A0A8I5ZSG1 (UniProtKB/TrEMBL)
- Sequence:
MSGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALM
hide sequence
Ensembl Acc Id:
ENSRNOP00000054738 ⟸ ENSRNOT00000057929
Ensembl Acc Id:
ENSRNOP00000062945 ⟸ ENSRNOT00000065393
Ensembl Acc Id:
ENSRNOP00000080240 ⟸ ENSRNOT00000112665
Ensembl Acc Id:
ENSRNOP00000081185 ⟸ ENSRNOT00000119292
RefSeq Acc Id:
XP_063129064 ⟸ XM_063272994
- Peptide Label:
isoform X4
- UniProtKB:
A0A8I5ZSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063129068 ⟸ XM_063272998
- Peptide Label:
isoform X8
- UniProtKB:
Q6AZ26 (UniProtKB/TrEMBL), A0A8I5ZSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063129067 ⟸ XM_063272997
- Peptide Label:
isoform X7
- UniProtKB:
F7FG31 (UniProtKB/TrEMBL), A0A8I5ZSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063129063 ⟸ XM_063272993
- Peptide Label:
isoform X3
- UniProtKB:
Q9Z2F5 (UniProtKB/Swiss-Prot), A6IK67 (UniProtKB/TrEMBL), A0A8I5ZSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063129066 ⟸ XM_063272996
- Peptide Label:
isoform X4
- UniProtKB:
A0A8I5ZSG1 (UniProtKB/TrEMBL)
RGD ID: 13699418 Promoter ID: EPDNEW_R9938 Type: initiation region Name: Ctbp1_1 Description: C-terminal binding protein 1 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 14 82,762,097 - 82,762,157 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2002-06-10
Ctbp1
C-terminal binding protein 1
Name updated
70584 APPROVED
Note Type
Note
Reference
gene_cellular_localization
protein is found in cytosol and may be associated with Golgi apparatus
69822
gene_expression
expressed in brain
69822
gene_physical_interaction
interacts with a bipartite motif located in the C- terminus of viral EBNA3A protein
1298829
gene_physical_interaction
binds GTP and interacts with beta gamma subunit comples of G proteins
1298827
gene_process
negatively controls tubulation of Golgi structures after treatment with brefeldin A
69822
gene_process
acts as a transcriptional co-repressor
1298829
gene_process
may function in development, cell cycle regulation and cellular transformation
1298829
gene_protein
protein is ADP-ribosylated after exposure of cells to brefeldin A
69822
