Mas1 (MAS1 proto-oncogene, G protein-coupled receptor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mas1 (MAS1 proto-oncogene, G protein-coupled receptor) Rattus norvegicus
Analyze
Symbol: Mas1
Name: MAS1 proto-oncogene, G protein-coupled receptor
RGD ID: 3049
Description: Predicted to enable angiotensin receptor activity and peptide binding activity. Involved in several processes, including hippocampus development; positive regulation of DNA replication; and regulation of phosphate metabolic process. Located in cell surface. Used to study glaucoma and hypertension. Biomarker of chronic kidney disease; congestive heart failure; dilated cardiomyopathy; and primary biliary cholangitis. Orthologous to human MAS1 (MAS1 proto-oncogene, G protein-coupled receptor); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiotensin-(1-7) receptor; c-mas; MAS proto-oncogene; Mas-related G protein-coupled receptor a; MAS1 oncogene; Mgra; proto-oncogene Mas
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Mas1em1Mcwi  
Genetic Models: SS-Mas1em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,428,064 - 50,459,537 (+)NCBIGRCr8
mRatBN7.2147,879,956 - 47,911,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,880,309 - 47,911,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,571,963 - 48,603,158 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,557,771 - 54,588,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,647,488 - 48,678,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,076,761 - 48,108,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,077,033 - 48,108,216 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,644,462 - 51,675,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,154,786 - 42,185,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,157,730 - 42,188,693 (+)NCBI
Celera143,680,754 - 43,711,122 (+)NCBICelera
RH 3.4 Map1544.2RGD
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
6-propyl-2-thiouracil  (EXP)
Ac-Ser-Asp-Lys-Pro-OH  (ISO)
aldehydo-D-glucose  (EXP,ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
Candesartan cilexetil  (EXP)
captopril  (EXP,ISO)
chlorpyrifos  (EXP)
choline  (ISO)
clozapine  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dimethylarsinic acid  (ISO)
diminazene diaceturate  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
genistein  (ISO)
glucose  (EXP,ISO)
glycidol  (EXP)
glyphosate  (ISO)
goralatide  (ISO)
haloperidol  (EXP)
hydralazine  (ISO)
indoxyl sulfate  (EXP)
isoprenaline  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
losartan  (ISO)
N-methylnicotinate  (EXP,ISO)
olmesartan  (EXP)
oltipraz  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perindopril  (EXP)
pirinixic acid  (ISO)
pregabalin  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
telmisartan  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IDA)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
2. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
3. Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
4. Selective increase of angiotensin(1-7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training. Filho AG, etal., Exp Physiol. 2008 May;93(5):589-98.
5. Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2. Foureaux G, etal., Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4296-306. doi: 10.1167/iovs.12-11427.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
9. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
10. Upregulation Of Angiotensin Converting Enzyme 2 In Hepatic Fibrosis By Angiotensin Converting Enzyme Inhibitors: An In Vivo And In Vitro Study. Huang ML, etal., Clin Exp Pharmacol Physiol. 2009 Sep 28.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. The role of angiotensin-(1-7) receptor Mas in spermatogenesis in mice and rats. Leal MC, etal., J Anat. 2009 May;214(5):736-43.
13. The mas proto-oncogene is developmentally regulated in the rat central nervous system. Martin KA, etal., Brain Res Dev Brain Res. 1992 Jul 24;68(1):75-82.
14. Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues. Metzger R, etal., FEBS Lett. 1995 Jan 2;357(1):27-32.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Renal ACE and ACE2 expression in early diabetic rats. Moon JY, etal., Nephron Exp Nephrol. 2008;110(1):e8-e16. Epub 2008 Aug 4.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells. Ng HY, etal., PLoS One. 2014 Mar 10;9(3):e91517. doi: 10.1371/journal.pone.0091517. eCollection 2014.
19. Gonadotropin Stimulation Increases the Expression of Angiotensin-(1-7) and Mas Receptor in the Rat Ovary. Pereira VM, etal., Reprod Sci. 2009 Aug 24.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. The renin-angiotensin system: peptides and enzymes beyond angiotensin II. Reudelhuber TL Curr Opin Nephrol Hypertens. 2005 Mar;14(2):155-9.
22. A place in our hearts for the lowly angiotensin 1-7 peptide? Reudelhuber TL Hypertension. 2006 May;47(5):811-5. Epub 2006 Mar 6.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Tallant EA, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6. Epub 2005 Jun 10.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Reduction in renal ACE2 expression in subtotal nephrectomy is ameliorated with ACE inhibition. Velkoska E, etal., Clin Sci (Lond). 2009 Aug 21.
30. Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene. Walther T, etal., J Biol Chem 1998 May 8;273(19):11867-73.
31. Effects of angiotensin II on proximal tubular cells stably transfected with the c-mas oncogene. Wolf G and Neilson EG, Am J Physiol. 1992 Nov;263(5 Pt 2):F931-8.
32. Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells. Xue H, etal., Regul Pept. 2012 Aug 20;177(1-3):12-20. doi: 10.1016/j.regpep.2012.04.002. Epub 2012 May 1.
33. Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain. Young D, etal., Proc Natl Acad Sci U S A 1988 Jul;85(14):5339-42.
34. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
35. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.
Additional References at PubMed
PMID:12829792   PMID:15489334   PMID:16087780   PMID:16611642   PMID:17496218   PMID:18026570   PMID:19404405   PMID:21436210   PMID:22003054   PMID:22504011   PMID:22561450   PMID:22775972  
PMID:22811473   PMID:23174757   PMID:23873801   PMID:23909597   PMID:24041943   PMID:24168260   PMID:24583173   PMID:24711523   PMID:24819472   PMID:24824997   PMID:24877125   PMID:24914635  
PMID:24968411   PMID:25169953   PMID:25194129   PMID:25194138   PMID:25371522   PMID:25426615   PMID:25766467   PMID:25895850   PMID:26256416   PMID:26519026   PMID:27030624   PMID:27050934  
PMID:27628189   PMID:27660028   PMID:27960152   PMID:28082260   PMID:28656296   PMID:28940861   PMID:29928987   PMID:31328772   PMID:31406138   PMID:31843339   PMID:32324784   PMID:32851948  
PMID:33070664   PMID:34743271   PMID:35247425  


Genomics

Comparative Map Data
Mas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,428,064 - 50,459,537 (+)NCBIGRCr8
mRatBN7.2147,879,956 - 47,911,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,880,309 - 47,911,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,571,963 - 48,603,158 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,557,771 - 54,588,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,647,488 - 48,678,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,076,761 - 48,108,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,077,033 - 48,108,216 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,644,462 - 51,675,365 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,154,786 - 42,185,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,157,730 - 42,188,693 (+)NCBI
Celera143,680,754 - 43,711,122 (+)NCBICelera
RH 3.4 Map1544.2RGD
Cytogenetic Map1q11NCBI
MAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,888,787 - 159,917,447 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,890,988 - 159,917,447 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,312,020 - 160,338,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,247,964 - 160,249,098 (+)NCBINCBI36Build 36hg18NCBI36
Build 346160,298,384 - 160,299,519NCBI
Celera6160,974,252 - 160,975,386 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,798,119 - 157,799,253 (+)NCBIHuRef
CHM1_16160,590,238 - 160,591,372 (+)NCBICHM1_1
T2T-CHM13v2.06161,134,461 - 161,165,992 (+)NCBIT2T-CHM13v2.0
Mas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,056,981 - 13,087,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,059,966 - 13,087,030 (-)EnsemblGRCm39 Ensembl
GRCm381712,838,841 - 12,868,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,841,079 - 12,868,143 (-)EnsemblGRCm38mm10GRCm38
MGSCv371713,033,871 - 13,061,009 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,684,009 - 12,711,075 (-)NCBIMGSCv36mm8
Celera1712,872,985 - 12,900,041 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.69NCBI
Mas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,956,862 - 20,957,839 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,956,862 - 20,957,839 (-)NCBIChiLan1.0ChiLan1.0
MAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,989,640 - 180,015,684 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,894,549 - 177,920,364 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,774,098 - 157,799,983 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,785,263 - 162,802,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,801,416 - 162,802,393 (+)Ensemblpanpan1.1panPan2
MAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,090,041 - 49,105,244 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,090,041 - 49,105,244 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,931,512 - 49,946,711 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,272,721 - 49,299,228 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,274,155 - 49,289,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,156,624 - 49,171,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,028,114 - 49,043,315 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,643,019 - 49,658,218 (+)NCBIUU_Cfam_GSD_1.0
MAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,527,861 - 7,528,838 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,527,566 - 7,542,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,326,523 - 9,339,701 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,520,860 - 87,523,523 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,521,947 - 87,523,098 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,898,097 - 59,920,293 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,969,444 - 2,970,421 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,968,111 - 3,008,728 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mas1
187 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:121
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000020100
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat

Markers in Region
BB276039  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,911,325 - 47,911,450 (+)MAPPERmRatBN7.2
Rnor_6.0148,108,044 - 48,108,168NCBIRnor6.0
Rnor_5.0151,644,770 - 51,644,894UniSTSRnor5.0
RGSC_v3.4142,185,576 - 42,185,700UniSTSRGSC3.4
Celera143,710,948 - 43,711,072UniSTS
Cytogenetic Map1q11-q12UniSTS
BF386436  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,891,940 - 47,892,149 (+)MAPPERmRatBN7.2
Rnor_6.0148,088,663 - 48,088,871NCBIRnor6.0
Rnor_5.0151,663,532 - 51,663,740UniSTSRnor5.0
RGSC_v3.4142,166,411 - 42,166,619UniSTSRGSC3.4
Celera143,691,652 - 43,691,860UniSTS
RH 3.4 Map1539.4UniSTS
Cytogenetic Map1q11-q12UniSTS
RH94551  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,911,027 - 47,911,127 (+)MAPPERmRatBN7.2
Rnor_6.0148,107,746 - 48,107,845NCBIRnor6.0
Rnor_5.0151,645,093 - 51,645,192UniSTSRnor5.0
RGSC_v3.4142,185,278 - 42,185,377UniSTSRGSC3.4
Celera143,710,650 - 43,710,749UniSTS
RH 3.4 Map1544.2UniSTS
Cytogenetic Map1q11-q12UniSTS
BF414744  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,911,011 - 47,911,185 (+)MAPPERmRatBN7.2
Rnor_6.0148,107,730 - 48,107,903NCBIRnor6.0
Rnor_5.0151,645,035 - 51,645,208UniSTSRnor5.0
RGSC_v3.4142,185,262 - 42,185,435UniSTSRGSC3.4
Celera143,710,634 - 43,710,807UniSTS
RH 3.4 Map1563.3UniSTS
Cytogenetic Map1q11-q12UniSTS


Genetic Models
This gene Mas1 is modified in the following models/strains:
SS-Mas1em1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9
Low 7 12 2 2 2 7 9 22 7 19 11 7
Below cutoff 3 14 27 21 17 21 1 2 16 14 11 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HG426116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020100   ⟹   ENSRNOP00000020100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,880,309 - 47,911,498 (+)Ensembl
Rnor_6.0 Ensembl148,077,033 - 48,108,216 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104217   ⟹   ENSRNOP00000097396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,900,582 - 47,911,709 (+)Ensembl
RefSeq Acc Id: NM_012757   ⟹   NP_036889
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,428,090 - 50,459,277 (+)NCBI
mRatBN7.2147,880,309 - 47,911,500 (+)NCBI
Rnor_6.0148,077,033 - 48,108,218 (+)NCBI
Rnor_5.0151,644,462 - 51,675,365 (-)NCBI
RGSC_v3.4142,154,786 - 42,185,750 (+)RGD
Celera143,680,754 - 43,711,122 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227860   ⟹   XP_006227922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,446,962 - 50,459,537 (+)NCBI
mRatBN7.2147,899,794 - 47,911,500 (+)NCBI
Rnor_6.0148,093,445 - 48,108,021 (+)NCBI
Rnor_5.0151,644,462 - 51,675,365 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101408   ⟹   XP_038957336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,446,962 - 50,459,537 (+)NCBI
mRatBN7.2147,899,795 - 47,911,500 (+)NCBI
RefSeq Acc Id: XM_039101409   ⟹   XP_038957337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,428,064 - 50,459,537 (+)NCBI
mRatBN7.2147,879,956 - 47,911,500 (+)NCBI
RefSeq Acc Id: XM_039101416   ⟹   XP_038957344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,446,962 - 50,459,537 (+)NCBI
mRatBN7.2147,899,795 - 47,911,500 (+)NCBI
RefSeq Acc Id: XM_063281307   ⟹   XP_063137377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,445,359 - 50,459,537 (+)NCBI
RefSeq Acc Id: XM_063281312   ⟹   XP_063137382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,452,991 - 50,459,537 (+)NCBI
RefSeq Acc Id: XM_063281318   ⟹   XP_063137388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,446,962 - 50,459,537 (+)NCBI
RefSeq Acc Id: XM_063281319   ⟹   XP_063137389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,428,080 - 50,459,537 (+)NCBI
RefSeq Acc Id: XM_063281329   ⟹   XP_063137399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,428,064 - 50,459,537 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036889   ⟸   NM_012757
- UniProtKB: P12526 (UniProtKB/Swiss-Prot),   W8W3M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227922   ⟸   XM_006227860
- Peptide Label: isoform X1
- UniProtKB: P12526 (UniProtKB/Swiss-Prot),   W8W3M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020100   ⟸   ENSRNOT00000020100
RefSeq Acc Id: XP_038957337   ⟸   XM_039101409
- Peptide Label: isoform X1
- UniProtKB: P12526 (UniProtKB/Swiss-Prot),   W8W3M4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957336   ⟸   XM_039101408
- Peptide Label: isoform X1
- UniProtKB: P12526 (UniProtKB/Swiss-Prot),   W8W3M4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957344   ⟸   XM_039101416
- Peptide Label: isoform X1
- UniProtKB: P12526 (UniProtKB/Swiss-Prot),   W8W3M4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000097396   ⟸   ENSRNOT00000104217
RefSeq Acc Id: XP_063137399   ⟸   XM_063281329
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137389   ⟸   XM_063281319
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137377   ⟸   XM_063281307
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137388   ⟸   XM_063281318
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137382   ⟸   XM_063281312
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12526-F1-model_v2 AlphaFold P12526 1-324 view protein structure
MAS I-TASSER model P12526 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689618
Promoter ID:EPDNEW_R141
Type:single initiation site
Name:Mas1_1
Description:MAS1 proto-oncogene, G protein-coupled receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,076,990 - 48,077,050EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3049 AgrOrtholog
BioCyc Gene G2FUF-61577 BioCyc
Ensembl Genes ENSRNOG00000014971 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027635 UniProtKB/Swiss-Prot
  ENSRNOG00060009693 UniProtKB/Swiss-Prot
  ENSRNOG00065029142 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020100 ENTREZGENE
  ENSRNOT00000020100.6 UniProtKB/Swiss-Prot
  ENSRNOT00000104217.1 UniProtKB/Swiss-Prot
  ENSRNOT00055047860 UniProtKB/Swiss-Prot
  ENSRNOT00055047868 UniProtKB/Swiss-Prot
  ENSRNOT00060016345 UniProtKB/Swiss-Prot
  ENSRNOT00060016354 UniProtKB/Swiss-Prot
  ENSRNOT00065050341 UniProtKB/Swiss-Prot
  ENSRNOT00065050362 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131760 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proto-oncogene_Mas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25153 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93580 IMAGE-MGC_LOAD
NCBI Gene 25153 ENTREZGENE
PANTHER MAS-RELATED G-PROTEIN COUPLED RECEPTOR MRG-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAS1 RGD
PhenoGen Mas1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MASONCOGENE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014971 RatGTEx
  ENSRNOG00055027635 RatGTEx
  ENSRNOG00060009693 RatGTEx
  ENSRNOG00065029142 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC235714
UniProt MAS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  W8W3M4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mas1  MAS1 oncogene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hippocampus and cerebral cortex 728946