Rac1 (Rac family small GTPase 1) - Rat Genome Database

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Gene: Rac1 (Rac family small GTPase 1) Rattus norvegicus
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Symbol: Rac1
Name: Rac family small GTPase 1
RGD ID: 619755
Description: Enables several functions, including GTP binding activity; Rho GDP-dissociation inhibitor binding activity; and enzyme binding activity. Involved in several processes, including Rac protein signal transduction; actin cytoskeleton organization; and positive regulation of plasma membrane bounded cell projection assembly. Located in Golgi membrane; cytosol; and dendritic spine. Is active in GABA-ergic synapse. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; INTERACTS WITH 11-deoxycorticosterone; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: p21-Rac1; ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,150,411 - 16,170,864 (+)NCBIGRCr8
mRatBN7.21211,037,028 - 11,057,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,036,698 - 11,057,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,844,100 - 11,864,510 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,467,387 - 12,487,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,492,647 - 11,513,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxycoumarin  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
7,8-diacetoxy-4-methylcoumarin  (ISO)
acetylsalicylic acid  (ISO)
acteoside  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
azathioprine  (ISO)
azithromycin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cisplatin  (EXP,ISO)
clemizole  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
D-glucose  (EXP,ISO)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
Dimethyldithiophosphate  (ISO)
Dimethylphosphate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
farnesyl diphosphate  (ISO)
felodipine  (ISO)
flavonoids  (ISO)
flubendazole  (ISO)
folic acid  (ISO)
folpet  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geranylgeraniol  (ISO)
glucose  (EXP,ISO)
graphene oxide  (ISO)
GTP  (EXP,ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
GYS32661  (ISO)
haloperidol  (EXP)
heparin  (EXP)
indometacin  (EXP)
irbesartan  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
kanamycin A  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
luteolin  (ISO)
Maduramicin  (EXP)
mebendazole  (ISO)
melittin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methohexital  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
mevalonic acid  (EXP,ISO)
mevastatin  (ISO)
ML-7  (EXP)
mycophenolic acid  (EXP)
N-acetyl-L-cysteine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nebivolol  (EXP)
nitrofen  (EXP)
NSC 23766  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
pamidronate  (ISO)
PD 0325901  (ISO)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
plitidepsin  (ISO)
poly(I:C)  (EXP,ISO)
potassium chromate  (ISO)
propiconazole  (EXP)
pyrrolidine dithiocarbamate  (ISO)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
Risedronate sodium  (ISO)
ropivacaine  (ISO)
rotenone  (EXP)
ruxolitinib  (ISO)
secobarbital  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
styrene oxide  (ISO)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tetrachloromethane  (ISO)
thiamylal  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
Triptolide  (EXP)
Tubeimoside II  (ISO)
uranium atom  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (EXP)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IDA,IEA,ISO)
actin filament organization  (IBA,IMP)
actin filament polymerization  (ISO)
anatomical structure arrangement  (ISO)
angiotensin-activated signaling pathway involved in heart process  (ISO)
auditory receptor cell morphogenesis  (ISO)
axon guidance  (ISO)
bone resorption  (IDA)
cell adhesion  (ISO)
cell chemotaxis  (IBA)
cell migration  (IEA,ISO)
cell motility  (ISO,ISS)
cell projection assembly  (IBA)
cell-cell junction organization  (ISO)
cellular response to mechanical stimulus  (IDA)
cerebral cortex GABAergic interneuron development  (ISO)
cerebral cortex radially oriented cell migration  (ISO)
chemotaxis  (IMP)
cochlea morphogenesis  (ISO)
cortical cytoskeleton organization  (IBA,IEA)
cytoskeleton organization  (ISO)
dendrite development  (ISO)
dendrite morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic olfactory bulb interneuron precursor migration  (ISO)
endocytosis  (ISO)
engulfment of apoptotic cell  (IBA,IEA,ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
epithelial cell morphogenesis  (ISO)
erythrocyte enucleation  (ISO)
establishment or maintenance of cell polarity  (IBA,IEA)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
hepatocyte growth factor receptor signaling pathway  (IEA,ISO)
homeostasis of number of cells within a tissue  (ISO)
hyperosmotic response  (ISO)
interneuron migration  (ISO)
lamellipodium assembly  (IEA,ISO)
localization within membrane  (IEA,ISO)
mast cell chemotaxis  (IMP)
midbrain dopaminergic neuron differentiation  (ISO)
motor neuron axon guidance  (IBA,IEA)
negative regulation of fibroblast migration  (IEA,ISO)
negative regulation of interleukin-23 production  (IEA,ISO)
neuron migration  (ISO,ISS)
neuron projection morphogenesis  (ISO)
non-canonical Wnt signaling pathway  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA replication  (IMP)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of filopodium assembly  (IMP)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP,ISO)
positive regulation of lamellipodium assembly  (IEA,IMP,ISO)
positive regulation of microtubule polymerization  (IEA,ISO)
positive regulation of neutrophil chemotaxis  (IEA,ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (IEA,ISO,ISS)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISO)
postsynaptic actin cytoskeleton organization  (EXP,IDA,IMP)
protein localization to plasma membrane  (ISO)
Rac protein signal transduction  (IBA,IDA,ISO,TAS)
regulation of actin cytoskeleton organization  (IBA,IEA)
regulation of cell adhesion involved in heart morphogenesis  (ISO)
regulation of cell migration  (ISO,ISS)
regulation of cell morphogenesis  (ISO)
regulation of cell shape  (IBA,IEA)
regulation of cell size  (IEA,ISO)
regulation of ERK5 cascade  (ISO)
regulation of fibroblast migration  (ISO)
regulation of lamellipodium assembly  (ISO)
regulation of neuron maturation  (ISO)
regulation of neuron migration  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neutrophil migration  (IBA)
regulation of nitric oxide biosynthetic process  (IGI)
regulation of postsynapse assembly  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of respiratory burst  (IEA,ISO)
regulation of stress fiber assembly  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
response to lipopolysaccharide  (ISO)
ruffle assembly  (IEA,ISO)
ruffle organization  (ISO)
semaphorin-plexin signaling pathway  (IMP)
small GTPase-mediated signal transduction  (IEA,ISO)
sphingosine-1-phosphate receptor signaling pathway  (IEA,ISO)
substrate adhesion-dependent cell spreading  (IEA,ISO,ISS)
synaptic transmission, GABAergic  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
amyotrophic lateral sclerosis pathway  (IEA)
Arf family mediated signaling pathway  (ISO)
azathioprine pharmacodynamics pathway  (ISO)
B cell receptor signaling pathway   (IEA)
c-Jun N-terminal kinases MAPK signaling pathway  (ISO)
ceramide signaling pathway  (IEA)
chemokine mediated signaling pathway   (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway  (ISO)
eicosanoid signaling pathway  (ISO)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway   (IEA)
insulin responsive facilitative sugar transporter mediated glucose transport pathway   (ISO)
interleukin-6 signaling pathway  (ISO)
mercaptopurine pharmacodynamics pathway  (ISO)
mercaptopurine pharmacokinetics pathway   (ISO)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (ISO)
myocarditis pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway   (IEA)
p38 MAPK signaling pathway   (ISO)
pancreatic cancer pathway  (IEA)
phagocytosis pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
renal cell carcinoma pathway  (IEA)
Rho/Rac/Cdc42 mediated signaling pathway  (IMP,ISO)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway  (ISO)
tioguanine pharmacodynamics pathway   (ISO)
Toll-like receptor signaling pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling, non-canonical pathway   (ISO)
Wnt signaling, the planar cell polarity pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2. RAC1b overexpression correlates with poor prognosis in KRAS/BRAF WT metastatic colorectal cancer patients treated with first-line FOLFOX/XELOX chemotherapy. Alonso-Espinaco V, etal., Eur J Cancer. 2014 Jul;50(11):1973-81. doi: 10.1016/j.ejca.2014.04.019. Epub 2014 May 12.
3. Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Asahara S, etal., Diabetologia. 2013 May;56(5):1088-97. doi: 10.1007/s00125-013-2849-5. Epub 2013 Feb 15.
4. Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration. Ashino T, etal., Circ Res. 2010 Sep 17;107(6):787-99. doi: 10.1161/CIRCRESAHA.110.225334. Epub 2010 Jul 29.
5. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer KL, etal., Mol Biol Cell. 1998 Mar;9(3):561-73.
6. Inhibition of growth and migration of cholangiocarcinoma cells by pamidronate. Buranrat B, etal., Exp Ther Med. 2019 Nov;18(5):3977-3983. doi: 10.3892/etm.2019.8041. Epub 2019 Sep 23.
7. A bibenzyl from Dendrobium ellipsophyllum inhibits migration in lung cancer cells. Chaotham C and Chanvorachote P, J Nat Med. 2015 Oct;69(4):565-74. doi: 10.1007/s11418-015-0925-5. Epub 2015 Jun 25.
8. Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. Chen JL, etal., FEBS Lett. 2004 May 21;566(1-3):281-6.
9. CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling. Chen Q, etal., J Neurosci. 2010 Sep 22;30(38):12777-86. doi: 10.1523/JNEUROSCI.1102-10.2010.
10. Cellular function of RhoGDI-alpha mediates the cycling of Rac1 and the regulation of pancreatic beta cell death. Cho Y, etal., Transplant Proc. 2012 May;44(4):1083-5. doi: 10.1016/j.transproceed.2012.03.021.
11. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
12. Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy. Custodis F, etal., Cardiovasc Res. 2006 Jul 15;71(2):342-51. Epub 2006 Apr 19.
13. Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. Dovas A, etal., J Biol Chem. 2010 Jul 23;285(30):23296-308. doi: 10.1074/jbc.M109.098129. Epub 2010 May 15.
14. Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer. Du J, etal., Cancer Gene Ther. 2011 Feb;18(2):135-43. doi: 10.1038/cgt.2010.64. Epub 2010 Oct 29.
15. Clinical value of Tiam1-Rac1 signaling in primary gallbladder carcinoma. Du X, etal., Med Oncol. 2012 Sep;29(3):1873-8. doi: 10.1007/s12032-011-0046-2. Epub 2011 Aug 19.
16. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
17. MicroRNA-142-3p Promotes Cellular Invasion of Colorectal Cancer Cells by Activation of RAC1. Gao X, etal., Technol Cancer Res Treat. 2018 Jan 1;17:1533033818790508. doi: 10.1177/1533033818790508.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. DAMTC regulates cytoskeletal reorganization and cell motility in human lung adenocarcinoma cell line: an integrated proteomics and transcriptomics approach. Goel A, etal., Cell Death Dis. 2012 Oct 11;3(10):e402. doi: 10.1038/cddis.2012.141.
20. RAC1b Overexpression Confers Resistance to Chemotherapy Treatment in Colorectal Cancer. Goka ET, etal., Mol Cancer Ther. 2019 May;18(5):957-968. doi: 10.1158/1535-7163.MCT-18-0955. Epub 2019 Mar 29.
21. Small interfering RNA targeting Rac1 sensitizes colon cancer to dihydroartemisinin-induced cell cycle arrest and inhibited cell migration by suppressing NFκB activity. Han P, etal., Mol Cell Biochem. 2013 Jul;379(1-2):171-80. doi: 10.1007/s11010-013-1639-1. Epub 2013 Apr 5.
22. Early requirement of Rac1 in a mouse model of pancreatic cancer. Heid I, etal., Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7. doi: 10.1053/j.gastro.2011.04.043. Epub 2011 Apr 28.
23. The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B. Higuchi Y, etal., J Biol Chem 2003 Jun 6;278(23):20770-7.
24. Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. Jordan P, etal., Oncogene. 1999 Nov 18;18(48):6835-9.
25. Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure. Kacimi R and Gerdes AM, Hypertension. 2003 Apr;41(4):968-77. Epub 2003 Mar 17.
26. Effects of cell tension on the small GTPase Rac. Katsumi A, etal., J Cell Biol 2002 Jul 8;158(1):153-64. Epub 2002 Jul 8.
27. Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein. Kim Y, etal., J Biol Chem. 2012 Jul 27;287(31):25844-59. doi: 10.1074/jbc.M112.348284. Epub 2012 Jun 7.
28. HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases. Kogler M, etal., Cancer Res. 2020 Jul 15;80(14):3009-3022. doi: 10.1158/0008-5472.CAN-19-2270. Epub 2020 May 4.
29. Gene expression pattern of laser microdissected colonic crypts of adenomas with low grade dysplasia. Lechner S, etal., Gut. 2003 Aug;52(8):1148-53.
30. Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. Li X and Lee AY, J Biol Chem. 2010 Oct 15;285(42):32436-45. doi: 10.1074/jbc.M110.120451. Epub 2010 Aug 9.
31. Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression. Lo LH, etal., Biochem Biophys Res Commun. 2021 Feb 19;541:70-77. doi: 10.1016/j.bbrc.2021.01.017. Epub 2021 Jan 19.
32. Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway. Masraksa W, etal., Nutr Res Pract. 2020 Apr;14(2):127-133. doi: 10.4162/nrp.2020.14.2.127. Epub 2019 Nov 22.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Distribution of Rho family GTPases in the adult rat hippocampus and cerebellum. O'Kane EM, etal., Brain Res Mol Brain Res 2003 May 26;114(1):1-8.
36. Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing. Pelisch F, etal., J Cell Biochem. 2012 Jul;113(7):2319-29. doi: 10.1002/jcb.24103.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
40. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. Powner DJ, etal., Mol Biol Cell 2002 Apr;13(4):1252-62.
41. Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma. Qi Y, etal., ORL J Otorhinolaryngol Relat Spec. 2009;71(3):163-71. doi: 10.1159/000223440. Epub 2009 Jun 9.
42. Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1. Rao J, etal., Cancer Lett. 2015 Mar 1;358(1):76-84. doi: 10.1016/j.canlet.2014.12.040. Epub 2014 Dec 18.
43. Rac-GTPase, osteoclast cytoskeleton and bone resorption. Razzouk S, etal., Eur J Cell Biol. 1999 Apr;78(4):249-55.
44. GOA pipeline RGD automated data pipeline
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Rosso SB, etal., Nat Neurosci. 2005 Jan;8(1):34-42. Epub 2004 Dec 19.
47. Requirement of Rac1 in the development of cardiac hypertrophy. Satoh M, etal., Proc Natl Acad Sci U S A. 2006 May 9;103(19):7432-7. Epub 2006 May 1.
48. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
49. Verbascoside Attenuates Rac-1 and HIF-1α Signaling Cascade in Colorectal Cancer Cells. Seyfi D, etal., Anticancer Agents Med Chem. 2018;18(15):2149-2155. doi: 10.2174/1871520618666180611112125.
50. Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. Shekarabi M, etal., J Neurosci. 2005 Mar 23;25(12):3132-41.
51. GIT1 and ßPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission. Smith KR, etal., Cell Rep. 2014 Oct 9;9(1):298-310. doi: 10.1016/j.celrep.2014.08.061. Epub 2014 Oct 2.
52. Possible role of direct Rac1-Rab7 interaction in ruffled border formation of osteoclasts. Sun Y, etal., J Biol Chem. 2005 Sep 16;280(37):32356-61. Epub 2005 Jul 21.
53. The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Takami Y, etal., Dig Dis Sci. 2008 Feb;53(2):467-73. Epub 2007 Jun 28.
54. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. Teramoto H, etal., J Biol Chem. 1996 Nov 1;271(44):27225-8.
55. Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1. Wang P, etal., Oncogene. 2014 Jan 23;33(4):514-24. doi: 10.1038/onc.2012.598. Epub 2013 Jan 21.
56. Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression. Wang Z, etal., Exp Mol Med. 2009 Oct 31;41(10):717-27. doi: 10.3858/emm.2009.41.10.078.
57. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. Wilhelm M, etal., J Biol Chem. 2012 Jan 13;287(3):2247-56. doi: 10.1074/jbc.M111.269431. Epub 2011 Nov 28.
58. Triclosan potentiates epithelial-to-mesenchymal transition in anoikis-resistant human lung cancer cells. Winitthana T, etal., PLoS One. 2014 Oct 16;9(10):e110851. doi: 10.1371/journal.pone.0110851. eCollection 2014.
59. Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts. Woo CH and Kim JH, Mol Cells 2002 Jun 30;13(3):470-5.
60. Eotaxin induces migration of RBL-2H3 mast cells via a Rac-ERK-dependent pathway. Woo CH, etal., Biochem Biophys Res Commun. 2002 Nov 1;298(3):392-7.
61. Leukotriene B(4) stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis. Woo CH, etal., J Biol Chem 2002 Mar 8;277(10):8572-8. Epub 2001 Dec 27.
62. Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma. Wu YJ, etal., Asia Pac J Clin Oncol. 2014 Jun;10(2):e33-9. doi: 10.1111/ajco.12052. Epub 2013 Jan 8.
63. Effect of blocking Rac1 expression in cholangiocarcinoma QBC939 cells. Xudong L and Guangyi W, Braz J Med Biol Res. 2011 May;44(5):483-8. doi: 10.1590/S0100-879X2011007500057. Epub 2011 May 2.
64. Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. Yang W, etal., Jpn J Clin Oncol. 2010 Nov;40(11):1053-9. doi: 10.1093/jjco/hyq086. Epub 2010 Jun 3.
65. Potential role of lncRNA HULC/miR‑128‑3p/RAC1 axis in the inflammatory response during LPS‑induced sepsis in HMEC‑1 cells. Yang W, etal., Mol Med Rep. 2020 Dec;22(6):5095-5104. doi: 10.3892/mmr.2020.11601. Epub 2020 Oct 14.
66. Role of EHD2 in migration and invasion of human breast cancer cells. Yang X, etal., Tumour Biol. 2015 May;36(5):3717-26. doi: 10.1007/s13277-014-3011-9. Epub 2015 Jan 5.
67. Expression of Rac1, HIF-1α, and VEGF in gastric carcinoma: correlation with angiogenesis and prognosis. Zhan H, etal., Onkologie. 2013;36(3):102-7. doi: 10.1159/000348525. Epub 2013 Feb 25.
68. A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. Zhang H, etal., J Neurosci. 2005 Mar 30;25(13):3379-88.
69. Ropivacaine inhibits the migration of esophageal cancer cells via sodium-channel-independent but prenylation-dependent inhibition of Rac1/JNK/paxillin/FAK. Zhang Y, etal., Biochem Biophys Res Commun. 2018 Jul 2;501(4):1074-1079. doi: 10.1016/j.bbrc.2018.05.110. Epub 2018 May 21.
70. RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3. Zhou K, etal., Lab Invest. 2018 Aug;98(8):989-998. doi: 10.1038/s41374-018-0071-2. Epub 2018 Jun 8.
71. Rho GTPases: RAC1 polymorphisms affected platinum-based chemotherapy toxicity in lung cancer patients. Zou T, etal., Cancer Chemother Pharmacol. 2016 Aug;78(2):249-58. doi: 10.1007/s00280-016-3072-0. Epub 2016 Jun 14.
Additional References at PubMed
PMID:8625410   PMID:8631991   PMID:9312003   PMID:10036235   PMID:10699171   PMID:10934045   PMID:10954424   PMID:12213441   PMID:12446704   PMID:12525493   PMID:12612085   PMID:12699088  
PMID:12719791   PMID:12777392   PMID:12783890   PMID:12853475   PMID:12915445   PMID:14516655   PMID:14570905   PMID:14573547   PMID:14580336   PMID:14657280   PMID:14736704   PMID:15037605  
PMID:15121898   PMID:15210825   PMID:15213258   PMID:15226395   PMID:15249579   PMID:15262848   PMID:15308668   PMID:15308673   PMID:15351707   PMID:15467718   PMID:15494521   PMID:15601624  
PMID:15611338   PMID:15629443   PMID:15634677   PMID:15721239   PMID:15723051   PMID:15728191   PMID:15728722   PMID:15826947   PMID:16092944   PMID:16168664   PMID:16195887   PMID:16283857  
PMID:16291935   PMID:16354758   PMID:16439689   PMID:16515795   PMID:16636067   PMID:16801538   PMID:16954223   PMID:16982892   PMID:17085464   PMID:17088251   PMID:17109063   PMID:17109064  
PMID:17130476   PMID:17183546   PMID:17207463   PMID:17300916   PMID:17350025   PMID:17409253   PMID:17515454   PMID:17515837   PMID:17561310   PMID:17687038   PMID:17702745   PMID:17982273  
PMID:18006851   PMID:18079208   PMID:18156211   PMID:18172037   PMID:18218673   PMID:18316075   PMID:18335519   PMID:18567639   PMID:18599477   PMID:18805958   PMID:18953410   PMID:19007770  
PMID:19027829   PMID:19052208   PMID:19067793   PMID:19085564   PMID:19126672   PMID:19261846   PMID:19289122   PMID:19356729   PMID:19368836   PMID:19403692   PMID:19581409   PMID:19625648  
PMID:19787194   PMID:19812310   PMID:19850129   PMID:19854265   PMID:19890013   PMID:19923407   PMID:19934221   PMID:20004474   PMID:20016102   PMID:20018732   PMID:20069557   PMID:20097736  
PMID:20139976   PMID:20335472   PMID:20339116   PMID:20363326   PMID:20387077   PMID:20458337   PMID:20519585   PMID:20530489   PMID:20578145   PMID:20691665   PMID:20696841   PMID:20808927  
PMID:20817060   PMID:20830300   PMID:20875796   PMID:20926685   PMID:20943855   PMID:20962234   PMID:21107423   PMID:21131638   PMID:21178006   PMID:21215756   PMID:21346419   PMID:21386710  
PMID:21423176   PMID:21457935   PMID:21460187   PMID:21464391   PMID:21474673   PMID:21483795   PMID:21660950   PMID:21683721   PMID:21765214   PMID:21814770   PMID:21816966   PMID:21963650  
PMID:22036506   PMID:22114025   PMID:22128191   PMID:22157753   PMID:22232135   PMID:22262456   PMID:22322064   PMID:22345572   PMID:22384148   PMID:22467863   PMID:22750946   PMID:22871113  
PMID:22890232   PMID:22959435   PMID:23012366   PMID:23027656   PMID:23109420   PMID:23129259   PMID:23153365   PMID:23184663   PMID:23258346   PMID:23325254   PMID:23376485   PMID:23499910  
PMID:23528453   PMID:23533145   PMID:23533177   PMID:23534605   PMID:23564082   PMID:23620790   PMID:23633677   PMID:23640896   PMID:23686855   PMID:23720743   PMID:23967341   PMID:23979707  
PMID:24123220   PMID:24195795   PMID:24248991   PMID:24297929   PMID:24352656   PMID:24522191   PMID:24553575   PMID:24625528   PMID:24660528   PMID:24752318   PMID:24859002   PMID:24915967  
PMID:25074804   PMID:25164814   PMID:25198505   PMID:25248834   PMID:25298426   PMID:25331951   PMID:25382267   PMID:25479592   PMID:25502873   PMID:25514037   PMID:25613020   PMID:25666619  
PMID:25794483   PMID:25796615   PMID:25820249   PMID:25864429   PMID:25865668   PMID:25957600   PMID:26272757   PMID:26319681   PMID:26323693   PMID:26543024   PMID:26690896   PMID:26700000  
PMID:26707876   PMID:26809475   PMID:26824355   PMID:27050391   PMID:27093550   PMID:27159442   PMID:27163367   PMID:27355516   PMID:27412363   PMID:27662902   PMID:27886395   PMID:27917469  
PMID:28013306   PMID:28119263   PMID:28161375   PMID:28220272   PMID:28274785   PMID:28320863   PMID:28336111   PMID:28630256   PMID:28683507   PMID:28828705   PMID:28849230   PMID:28886345  
PMID:28934903   PMID:29046349   PMID:29191942   PMID:29476059   PMID:29494287   PMID:30013448   PMID:30257103   PMID:30448045   PMID:31202817   PMID:32001733   PMID:32452765   PMID:32542704  
PMID:32592615   PMID:32641997   PMID:33347743   PMID:33800361   PMID:34047412   PMID:34147481   PMID:34597250   PMID:34753065   PMID:35108117   PMID:36562344   PMID:36938611   PMID:37598223  
PMID:37735499   PMID:37984604  


Genomics

Comparative Map Data
Rac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,150,411 - 16,170,864 (+)NCBIGRCr8
mRatBN7.21211,037,028 - 11,057,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,036,698 - 11,057,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,844,100 - 11,864,510 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,467,387 - 12,487,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,492,647 - 11,513,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
RAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,374,527 - 6,403,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl76,374,527 - 6,403,967 (+)EnsemblGRCh38hg38GRCh38
GRCh3776,414,158 - 6,443,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,380,651 - 6,410,123 (+)NCBINCBI36Build 36hg18NCBI36
Celera76,291,529 - 6,321,004 (-)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef76,287,239 - 6,316,490 (+)NCBIHuRef
CHM1_176,413,683 - 6,443,197 (+)NCBICHM1_1
T2T-CHM13v2.076,493,927 - 6,523,370 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,460,486 - 6,489,951 (+)NCBI
Rac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,491,236 - 143,513,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,489,389 - 143,513,791 (-)EnsemblGRCm39 Ensembl
GRCm385143,505,481 - 143,528,031 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,503,634 - 143,528,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv375144,266,349 - 144,288,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,761,100 - 143,783,611 (-)NCBIMGSCv36mm8
Celera5140,552,192 - 140,574,740 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.22NCBI
Rac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,270,159 - 13,311,351 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546013,270,159 - 13,295,562 (-)NCBIChiLan1.0ChiLan1.0
RAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2611,267,125 - 11,296,710 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1759,591,833 - 59,621,373 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v077,039,379 - 7,068,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.176,559,590 - 6,599,814 (+)NCBIpanpan1.1PanPan1.1panPan2
RAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,726,259 - 11,758,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl611,655,494 - 11,757,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,358,080 - 13,382,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0611,733,309 - 11,759,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl611,733,323 - 11,759,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1611,609,365 - 11,633,590 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,589,106 - 11,613,379 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,817,075 - 11,841,312 (+)NCBIUU_Cfam_GSD_1.0
Rac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344139,822,631 - 139,837,571 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936750107,689 - 122,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936750107,689 - 122,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,781,780 - 4,803,543 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,781,776 - 4,803,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,583,609 - 15,610,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,583,516 - 15,610,328 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666102459,743 - 488,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474030,911,598 - 30,934,025 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474030,912,841 - 30,933,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rac1
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:126
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000001417
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat

Markers in Region
RH140831  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,057,339 - 11,057,559 (+)MAPPERmRatBN7.2
Rnor_6.01213,110,681 - 13,110,900NCBIRnor6.0
Rnor_5.01215,153,830 - 15,154,049UniSTSRnor5.0
RGSC_v3.41211,400,620 - 11,400,839UniSTSRGSC3.4
Celera1212,851,413 - 12,851,632UniSTS
RH 3.4 Map12145.61UniSTS
Cytogenetic Map12p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001417   ⟹   ENSRNOP00000001417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1213,090,367 - 13,111,873 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087094   ⟹   ENSRNOP00000071616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,046,647 - 11,057,251 (+)Ensembl
Rnor_6.0 Ensembl1213,097,269 - 13,110,592 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092558   ⟹   ENSRNOP00000075900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,036,698 - 11,057,251 (+)Ensembl
Rnor_6.0 Ensembl1213,090,172 - 13,109,135 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092628   ⟹   ENSRNOP00000075897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1213,102,019 - 13,102,706 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113039   ⟹   ENSRNOP00000076799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,043,004 - 11,057,251 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114561   ⟹   ENSRNOP00000091529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,043,004 - 11,057,251 (+)Ensembl
RefSeq Acc Id: NM_134366   ⟹   NP_599193
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,150,643 - 16,170,864 (+)NCBI
mRatBN7.21211,037,028 - 11,057,251 (+)NCBI
Rnor_6.01213,090,372 - 13,110,592 (+)NCBI
Rnor_5.01215,133,521 - 15,153,741 (+)NCBI
RGSC_v3.41211,380,314 - 11,400,531 (+)RGD
Celera1212,831,091 - 12,851,324 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271554   ⟹   XP_063127624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,150,411 - 16,170,581 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_599193   ⟸   NM_134366
- UniProtKB: Q6RUV5 (UniProtKB/Swiss-Prot),   A0A0G2K0X4 (UniProtKB/TrEMBL),   A6K1K8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075897   ⟸   ENSRNOT00000092628
RefSeq Acc Id: ENSRNOP00000075900   ⟸   ENSRNOT00000092558
RefSeq Acc Id: ENSRNOP00000071616   ⟸   ENSRNOT00000087094
RefSeq Acc Id: ENSRNOP00000001417   ⟸   ENSRNOT00000001417
RefSeq Acc Id: ENSRNOP00000076799   ⟸   ENSRNOT00000113039
RefSeq Acc Id: ENSRNOP00000091529   ⟸   ENSRNOT00000114561
RefSeq Acc Id: XP_063127624   ⟸   XM_063271554
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6RUV5-F1-model_v2 AlphaFold Q6RUV5 1-192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698441
Promoter ID:EPDNEW_R8962
Type:initiation region
Name:Rac1_1
Description:ras-related C3 botulinum toxin substrate 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,090,171 - 13,090,231EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619755 AgrOrtholog
BioCyc Gene G2FUF-20008 BioCyc
Ensembl Genes ENSRNOG00000001068 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087094.2 UniProtKB/TrEMBL
  ENSRNOT00000092558 ENTREZGENE
  ENSRNOT00000092558.2 UniProtKB/TrEMBL
  ENSRNOT00000113039.1 UniProtKB/TrEMBL
  ENSRNOT00000114561.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363875 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Rac1 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24072:SF350 UniProtKB/TrEMBL
  RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3 UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RAC1 RGD
PhenoGen Rac1 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001068 RatGTEx
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0X4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0U1RS21_RAT UniProtKB/TrEMBL
  A0A8I5Y5L2_RAT UniProtKB/TrEMBL
  A0A8I6ADV8_RAT UniProtKB/TrEMBL
  A6K1K6_RAT UniProtKB/TrEMBL
  A6K1K8 ENTREZGENE, UniProtKB/TrEMBL
  Q6RUV5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 Rac1  Rac family small GTPase 1  Rac1  ras-related C3 botulinum toxin substrate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rac1  ras-related C3 botulinum toxin substrate 1    ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)  Name updated 1299863 APPROVED
2002-08-07 Rac1  ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes at the plasma membrane of RBL-2H3 cells in actin-rich structures with phospholipase D, ARF6, and PKC alpha following antigen stimulation 727254
gene_expression expressed in hippocampus and cerebellum 1299238
gene_process enhanced the expression of a kappaB and induced the degradation of IkappaBalpha 704329
gene_process essential for leukotriene B4 induced production of reactive oxygen species, chemotaxis, and cellular proliferation 1299245
gene_process may play a role in synaptic plasticity in brain 1299238
gene_process may play a role in cellular motility through regulation by stretch tension 1299247
gene_regulation activated by treatment of cells with lipopolysaccharide (LPS) 1299246