Xpo1 (exportin 1) - Rat Genome Database

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Gene: Xpo1 (exportin 1) Rattus norvegicus
Analyze
Symbol: Xpo1
Name: exportin 1
RGD ID: 620517
Description: Enables DNA-binding transcription factor binding activity and protein domain specific binding activity. Involved in several processes, including cellular response to salt; cellular response to triglyceride; and protein export from nucleus. Predicted to be located in several cellular components, including annulate lamellae; kinetochore; and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1); PARTICIPATES IN CRM1 export pathway; Hedgehog signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromosome region maintenance 1 protein homolog; exp1; exportin 1 (CRM1, yeast, homolog); exportin 1, CRM1 homolog; exportin 1, CRM1 homolog (yeast); exportin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,434,450 - 101,476,705 (+)NCBIGRCr8
mRatBN7.21497,233,282 - 97,275,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,233,270 - 97,275,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,571,539 - 101,607,053 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014102,815,887 - 102,851,401 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,287,455 - 99,322,969 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,007,421 - 108,049,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,007,724 - 108,049,660 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014108,082,784 - 108,124,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414103,943,249 - 103,978,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114103,962,459 - 103,997,928 (+)NCBI
Celera1496,216,463 - 96,251,770 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
aurantio-obtusin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
doxorubicin  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
leptomycin B  (ISO)
levofloxacin  (EXP)
menadione  (ISO)
methidathion  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulindac  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
annulate lamellae  (IEA,ISO)
Cajal body  (IEA)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
intracellular membrane-bounded organelle  (ISO)
kinetochore  (IEA,ISO,ISS)
nuclear membrane  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (ISO)
ribonucleoprotein complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of XPO1 Overexpression with NF-κB and Ki67 in Colorectal Cancer. Aladhraei M, etal., Asian Pac J Cancer Prev. 2019 Dec 1;20(12):3747-3754. doi: 10.31557/APJCP.2019.20.12.3747.
2. Nuclear export factor CRM1 interacts with nonstructural proteins NS2 from parvovirus minute virus of mice. Bodendorf U, etal., J Virol 1999 Sep;73(9):7769-79.
3. Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma. Chen L, etal., Biosci Rep. 2019 Aug 19;39(8). pii: BSR20190827. doi: 10.1042/BSR20190827. Print 2019 Aug 30.
4. Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression. Fei E, etal., J Biol Chem. 2010 Dec 3;285(49):38630-40. doi: 10.1074/jbc.M110.107912. Epub 2010 Oct 4.
5. XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer. Ferreiro-Neira I, etal., Clin Cancer Res. 2016 Apr 1;22(7):1663-73. doi: 10.1158/1078-0432.CCR-15-0978. Epub 2015 Nov 24.
6. Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site. Fukasawa M, etal., Biochem Biophys Res Commun. 2010 Jan 8;391(2):1166-9. doi: 10.1016/j.bbrc.2009.11.115. Epub 2009 Dec 17.
7. Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy. Gao W, etal., J Thorac Oncol. 2015 May;10(5):815-25. doi: 10.1097/JTO.0000000000000485.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Rat CRM1 is responsible for the poor activity of human T-cell leukemia virus type 1 Rex protein in rat cells. Hakata Y, etal., J Virol 2001 Dec;75(23):11515-25.
11. A novel circular RNA, circXPO1, promotes lung adenocarcinoma progression by interacting with IGF2BP1. Huang Q, etal., Cell Death Dis. 2020 Dec 2;11(12):1031. doi: 10.1038/s41419-020-03237-8.
12. Prognostic value of CRM1 in pancreas cancer. Huang WY, etal., Clin Invest Med. 2009 Dec 1;32(6):E315.
13. Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer. Inoue A, etal., Gastroenterology. 2021 Jul;161(1):196-210. doi: 10.1053/j.gastro.2021.03.022. Epub 2021 Mar 19.
14. CRM-1 knockdown inhibits extrahepatic cholangiocarcinoma tumor growth by blocking the nuclear export of p27Kip1. Luo J, etal., Int J Mol Med. 2016 Aug;38(2):381-90. doi: 10.3892/ijmm.2016.2628. Epub 2016 Jun 7.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. RNA Export through the NPC in Eukaryotes. Okamura M, etal., Genes (Basel). 2015 Mar 20;6(1):124-49. doi: 10.3390/genes6010124.
19. Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein. Ortega JF, etal., Oncotarget. 2016 Apr 26;7(17):24339-47. doi: 10.18632/oncotarget.8248.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer. Sexton R, etal., Int J Mol Sci. 2019 Sep 28;20(19). pii: ijms20194826. doi: 10.3390/ijms20194826.
26. Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor. Subhash VV, etal., Sci Rep. 2018 Aug 16;8(1):12248. doi: 10.1038/s41598-018-30686-1.
27. KPT-330 has antitumour activity against non-small cell lung cancer. Sun H, etal., Br J Cancer. 2014 Jul 15;111(2):281-91. doi: 10.1038/bjc.2014.260. Epub 2014 Jun 19.
28. Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer. Sun YQ, etal., World J Gastroenterol. 2017 Mar 21;23(11):2012-2022. doi: 10.3748/wjg.v23.i11.2012.
29. Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma. van der Watt PJ, etal., Oncol Rep. 2014 Aug;32(2):730-8. doi: 10.3892/or.2014.3231. Epub 2014 Jun 4.
30. Involvement of chromosome region maintenance 1 (CRM1) in the formation and progression of esophageal squamous cell carcinoma. Yang X, etal., Med Oncol. 2014 Sep;31(9):155. doi: 10.1007/s12032-014-0155-9. Epub 2014 Aug 23.
31. Nuclear export and cytoplasmic maturation of ribosomal subunits. Zemp I and Kutay U, FEBS Lett. 2007 Jun 19;581(15):2783-93. Epub 2007 May 11.
32. KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma. Zheng Y, etal., Cancer Chemother Pharmacol. 2014 Sep;74(3):487-95. doi: 10.1007/s00280-014-2495-8. Epub 2014 Jul 17.
33. Both high expression of nucleophosmin/B23 and CRM1 predicts poorer prognosis in human gastric cancer. Zhou F, etal., APMIS. 2016 Dec;124(12):1046-1053. doi: 10.1111/apm.12604. Epub 2016 Oct 6.
34. CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas. Zhou F, etal., Med Oncol. 2013 Dec;30(4):726. doi: 10.1007/s12032-013-0726-1. Epub 2013 Sep 12.
35. XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis. Zhu ZC, etal., Cell Death Dis. 2019 May 21;10(6):395. doi: 10.1038/s41419-019-1627-9.
Additional References at PubMed
PMID:10557333   PMID:11000203   PMID:11092755   PMID:11796723   PMID:12210765   PMID:12446771   PMID:12724356   PMID:12773398   PMID:14981260   PMID:15572669   PMID:15574332   PMID:15767664  
PMID:16236793   PMID:16297385   PMID:16316410   PMID:16459298   PMID:16997396   PMID:17363900   PMID:18496528   PMID:18606808   PMID:18809582   PMID:19064729   PMID:19699716   PMID:19946888  
PMID:19952108   PMID:21251165   PMID:22250199   PMID:22427340   PMID:23494640   PMID:23782956   PMID:29666234  


Genomics

Comparative Map Data
Xpo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,434,450 - 101,476,705 (+)NCBIGRCr8
mRatBN7.21497,233,282 - 97,275,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,233,270 - 97,275,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,571,539 - 101,607,053 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014102,815,887 - 102,851,401 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,287,455 - 99,322,969 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,007,421 - 108,049,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,007,724 - 108,049,660 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014108,082,784 - 108,124,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414103,943,249 - 103,978,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114103,962,459 - 103,997,928 (+)NCBI
Celera1496,216,463 - 96,251,770 (+)NCBICelera
Cytogenetic Map14q22NCBI
XPO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,477,849 - 61,538,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,476,032 - 61,538,741 (-)EnsemblGRCh38hg38GRCh38
GRCh37261,704,984 - 61,765,491 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,558,573 - 61,618,922 (-)NCBINCBI36Build 36hg18NCBI36
Build 34261,616,719 - 61,677,069NCBI
Celera261,550,297 - 61,610,634 (-)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,445,666 - 61,506,245 (-)NCBIHuRef
CHM1_1261,635,341 - 61,695,639 (-)NCBICHM1_1
T2T-CHM13v2.0261,483,936 - 61,544,825 (-)NCBIT2T-CHM13v2.0
Xpo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,205,768 - 23,248,250 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,206,055 - 23,248,249 (+)EnsemblGRCm39 Ensembl
GRCm381123,255,909 - 23,297,597 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,256,041 - 23,298,249 (+)EnsemblGRCm38mm10GRCm38
MGSCv371123,156,041 - 23,197,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361123,156,041 - 23,197,597 (+)NCBIMGSCv36mm8
Celera1125,383,230 - 25,424,813 (+)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.28NCBI
Xpo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542422,370,006 - 22,420,568 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542422,370,006 - 22,420,568 (+)NCBIChiLan1.0ChiLan1.0
XPO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21264,845,566 - 64,906,271 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A64,849,384 - 64,910,222 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A61,562,372 - 61,622,841 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A62,698,935 - 62,759,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A62,698,935 - 62,757,793 (-)Ensemblpanpan1.1panPan2
XPO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11061,541,647 - 61,588,397 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1061,542,211 - 61,585,054 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1061,432,066 - 61,478,799 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01062,551,228 - 62,597,765 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1062,549,829 - 62,598,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11062,236,087 - 62,282,603 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01062,538,737 - 62,585,449 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01062,833,751 - 62,880,490 (-)NCBIUU_Cfam_GSD_1.0
Xpo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629221,608,933 - 21,649,530 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364916,921,319 - 6,962,343 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364916,921,753 - 6,962,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XPO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl380,255,146 - 80,300,327 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1380,255,016 - 80,300,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2384,163,542 - 84,182,141 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XPO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11445,428,279 - 45,487,965 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1445,432,619 - 45,488,723 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604566,319,346 - 66,401,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xpo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624833375,820 - 424,499 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624833375,817 - 424,499 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Xpo1
161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:75
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000014062
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 10 74 35 41 11 8
Low 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014062   ⟹   ENSRNOP00000014062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1497,233,382 - 97,275,498 (+)Ensembl
Rnor_6.0 Ensembl14108,007,724 - 108,049,660 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101915   ⟹   ENSRNOP00000087052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1497,252,482 - 97,275,458 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114310   ⟹   ENSRNOP00000097648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1497,233,270 - 97,275,432 (+)Ensembl
RefSeq Acc Id: NM_053490   ⟹   NP_445942
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,434,450 - 101,476,705 (+)NCBI
mRatBN7.21497,233,282 - 97,275,536 (+)NCBI
Rnor_6.014108,013,281 - 108,048,950 (+)NCBI
Rnor_5.014108,082,784 - 108,124,516 (+)NCBI
RGSC_v3.414103,943,249 - 103,978,717 (+)RGD
Celera1496,216,463 - 96,251,770 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_445942   ⟸   NM_053490
- UniProtKB: Q80U96 (UniProtKB/Swiss-Prot),   A6JQ67 (UniProtKB/TrEMBL),   A0A8I6AT26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014062   ⟸   ENSRNOT00000014062
RefSeq Acc Id: ENSRNOP00000097648   ⟸   ENSRNOT00000114310
RefSeq Acc Id: ENSRNOP00000087052   ⟸   ENSRNOT00000101915
Protein Domains
Exportin-1 C-terminal   Importin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80U96-F1-model_v2 AlphaFold Q80U96 1-1071 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620517 AgrOrtholog
BioCyc Gene G2FUF-14777 BioCyc
Ensembl Genes ENSRNOG00000009935 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014062 ENTREZGENE
  ENSRNOT00000014062.5 UniProtKB/TrEMBL
  ENSRNOT00000101915.1 UniProtKB/TrEMBL
  ENSRNOT00000114310.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRM1_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exp1_repeat_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exportin-1/Importin-b-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Importin-beta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPO1/5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPO1_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XPO1_repeat_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85252 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 85252 ENTREZGENE
PANTHER EXPORTIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11223 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CRM1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRM1_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRM1_repeat_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRM1_repeat_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IBN_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xpo1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Xpo1 PhenoGen
PROSITE IMPORTIN_B_NT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009935 RatGTEx
SMART CRM1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IBN_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A738_RAT UniProtKB/TrEMBL
  A0A8I6AT26 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q6V5_RAT UniProtKB/TrEMBL
  A6JQ67 ENTREZGENE, UniProtKB/TrEMBL
  A6JQ69_RAT UniProtKB/TrEMBL
  Q80U96 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Xpo1  exportin 1  Xpo1  exportin 1, CRM1 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Xpo1  exportin 1, CRM1 homolog (yeast)    exportin 1 (CRM1, yeast, homolog)  Name updated 1299863 APPROVED
2002-08-07 Xpo1  exportin 1 (CRM1, yeast, homolog)      Symbol and Name status set to provisional 70820 PROVISIONAL