Kcnma1 (potassium calcium-activated channel subfamily M alpha 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Kcnma1 (potassium calcium-activated channel subfamily M alpha 1) Rattus norvegicus
Analyze
Symbol: Kcnma1
Name: potassium calcium-activated channel subfamily M alpha 1
RGD ID: 620715
Description: Enables identical protein binding activity and monoatomic ion channel activity. Involved in several processes, including negative regulation of small intestine smooth muscle contraction; positive regulation of neuron apoptotic process; and response to estrogen. Located in several cellular components, including external side of plasma membrane; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in glutamatergic synapse and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; generalized epilepsy; and paroxysmal nonkinesigenic dyskinesia 3. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1); INTERACTS WITH (+)-pilocarpine; (+)-Pimaric acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BK channel; BKCa; BKCA alpha; calcium-activated potassium channel alpha subunit; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; cbv1; k(VCA)alpha; KCa1.1; Kcnma; KCNMA1b; KCNMA1c; LOC498438; maxi K channel; maxiK; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo; slo homolog; slo-alpha; slo1; slowpoke homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnma1_v1   Kcnma1_v2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815351,065 - 1,057,117 (+)NCBIGRCr8
mRatBN7.215302,480 - 1,007,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15302,214 - 1,001,198 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15309,515 - 1,014,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0151,696,105 - 2,401,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015308,241 - 1,013,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015344,204 - 1,048,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15344,360 - 1,047,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015339,100 - 1,037,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415575,136 - 950,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115322,288 - 950,273NCBI
Celera153,556,267 - 4,246,392 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Kcnma1RatAlzheimer's disease onsetISOKCNMA1 (Homo sapiens)10412025DNA:SNP: :rs16934131 (human)RGD 
Kcnma1RatCOVID-19  ISOKCNMA1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Kcnma1RatExperimental Colitis  IEP 10412026mRNA and protein:increased expression:colonRGD 
Kcnma1RatExperimental Diabetes Mellitus  IEP 10412030mRNA more ...RGD 
1 to 14 of 14 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Kcnma1Ratautism spectrum disorder  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868 and PMID:27569545
Kcnma1RatCEREBELLAR ATROPHY, DEVELOPMENTAL DELAY, AND SEIZURES  ISOKCNMA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Kcnma1RatDevelopmental Disabilities  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:28492532
Kcnma1Ratepilepsy  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:28492532
Kcnma1Ratepilepsy  ISOKCNMA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Kcnma1Ratgenetic disease  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:12366739 more ...
Kcnma1RatGenitopatellar Syndrome  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Genitopatellar syndromeClinVarPMID:28492532
Kcnma1RatIdiopathic Generalized Epilepsy 16  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:25741868 and PMID:28492532
Kcnma1Ratintellectual disability  ISOKCNMA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19266219 more ...
Kcnma1RatLiang-Wang Syndrome  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Liang-Wang syndromeClinVarPMID:12366739 more ...
Kcnma1RatMuscle Hypotonia  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: poor muscle toneClinVarPMID:28492532
Kcnma1RatNeurodevelopmental Disorders  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental abnormalityClinVarPMID:25741868 more ...
Kcnma1Ratparoxysmal nonkinesigenic dyskinesia 3  ISOKCNMA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15937479 more ...
Kcnma1Ratspastic ataxia  ISOKCNMA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic ataxiaClinVarPMID:25741868
1 to 14 of 14 rows
1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Kcnma1Ratautistic disorder  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16946189
Kcnma1RatDiaphragmatic Hernia  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15088113
Kcnma1RatGrowth Disorders  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28242822
Kcnma1RatMetabolic Bone Diseases  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21695131
Kcnma1Ratmorbid obesity  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21708048
Kcnma1Ratobesity  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27605626
Kcnma1Ratparoxysmal nonkinesigenic dyskinesia 3  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Kcnma1RatPerinatal Death  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28242822
Kcnma1Ratpulmonary hypertension  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28090300
Kcnma1Ratrenal cell carcinoma  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23797736
Kcnma1Ratstatus epilepticus  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18695509
Kcnma1RatWeight Gain  ISOKCNMA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27605626
1 to 12 of 12 rows

1 to 20 of 186 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Kcnma1Rat(+)-pilocarpine decreases expressionEXP 6480464Pilocarpine results in decreased expression of KCNMA1 mRNACTDPMID:18695509
Kcnma1Rat(+)-Pimaric acid affects response to substanceEXP 6480464KCNMA1 mRNA affects the susceptibility to pimaric acidCTDPMID:19247476
Kcnma1Rat(R)-noradrenaline affects response to substanceEXP 6480464KCNMA1 protein affects the susceptibility to NorepinephrineCTDPMID:22226998
Kcnma1Rat1,2-dichloroethane increases expressionISOKcnma1 (Mus musculus)6480464ethylene dichloride results in increased expression of KCNMA1 mRNACTDPMID:28189721 and PMID:28960355
Kcnma1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of KCNMA1 mRNACTDPMID:17557909
Kcnma1Rat17beta-estradiol increases activityISOKCNMA1 (Homo sapiens)6480464Estradiol results in increased activity of KCNMA1 proteinCTDPMID:18068743
Kcnma1Rat17beta-estradiol multiple interactionsEXP 6480464Fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA alternative form] more ...CTDPMID:16102753
Kcnma1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of KCNMA1 mRNA more ...CTDPMID:16102753
Kcnma1Rat17beta-estradiol multiple interactionsISOKCNMA1 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in increased expression of KCNMA1 mRNA more ...CTDPMID:18068743 more ...
Kcnma1Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOKCNMA1 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of KCNMA1 mRNACTDPMID:29581250
Kcnma1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOKcnma1 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Kcnma1Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOKcnma1 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Kcnma1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Kcnma1Rat2,4-D multiple interactionsISOKcnma1 (Mus musculus)6480464[lard co-treated with Cholesterol more ...CTDPMID:37567420
Kcnma1Rat2-bromohexadecanoic acid multiple interactionsISOKCNMA1 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of KCNMA1 protein]CTDPMID:38195004
Kcnma1Rat2-methylcholine affects expressionISOKCNMA1 (Homo sapiens)6480464beta-methylcholine affects the expression of KCNMA1 mRNACTDPMID:21179406
Kcnma1Rat3,3',5,5'-tetrabromobisphenol A increases expressionISOKCNMA1 (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of KCNMA1 mRNACTDPMID:35321852
Kcnma1Rat3,3',5-triiodo-L-thyronine multiple interactionsISOKcnma1 (Mus musculus)6480464[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA and [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 proteinCTDPMID:27605626
Kcnma1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOKcnma1 (Mus musculus)6480464[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA and [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 proteinCTDPMID:27605626
Kcnma1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOKCNMA1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of KCNMA1 mRNACTDPMID:28628672

1 to 20 of 186 rows

Biological Process
1 to 20 of 69 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Kcnma1Ratadult walking behavior acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3050114 more ...RGDPMID:15184377 and PMID:15194823
Kcnma1Ratblood vessel diameter maintenance  IDA 1581588 RGD 
Kcnma1Ratchemical synaptic transmission acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3050114 PMID:15194823RGDPMID:15194823
Kcnma1Ratcircadian rhythm acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3053849 PMID:16845385RGDPMID:16845385
Kcnma1Ratcolumnar/cuboidal epithelial cell maturation acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3050114 PMID:15328414RGDPMID:15328414
Kcnma1Rateye blink reflex acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3050114 PMID:15194823RGDPMID:15194823
Kcnma1Ratinner ear auditory receptor cell differentiation acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3050114 PMID:15328414 and PMID:17074442RGDPMID:15328414 and PMID:17074442
Kcnma1Ratintracellular potassium ion homeostasis involved_inIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnma1Ratintracellular potassium ion homeostasis involved_inISOKCNMA1 (Homo sapiens)1624291 PMID:11245614RGDPMID:11245614
Kcnma1Ratlocomotor rhythm acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3053849 PMID:16845385RGDPMID:16845385
Kcnma1Ratmicturition acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3053849 PMID:15184377RGDPMID:15184377
Kcnma1Ratmicturition involved_inIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnma1Ratmicturition involved_inISOKCNMA1 (Homo sapiens)1624291 PMID:11641143RGDPMID:11641143
Kcnma1Ratmonoatomic ion transmembrane transport involved_inIEAUniProtKB-KW:KW-0407 and UniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
Kcnma1Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Kcnma1Ratmonoatomic ion transport involved_inIEAInterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Kcnma1Ratnegative regulation of cell volume involved_inIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnma1Ratnegative regulation of cell volume acts_upstream_of_or_withinISOKcnma1 (Mus musculus)1624291MGI:3053849 PMID:16873365RGDPMID:16873365
Kcnma1Ratnegative regulation of cell volume involved_inISOKCNMA1 (Homo sapiens)1624291 PMID:12388065RGDPMID:12388065
Kcnma1Ratnegative regulation of small intestine smooth muscle contraction  IMP 10412032 RGD 
1 to 20 of 69 rows

Cellular Component
1 to 20 of 37 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Kcnma1Ratapical plasma membrane located_inIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnma1Ratapical plasma membrane located_inISOKcnma1 (Mus musculus)1624291 PMID:17135251RGDPMID:17135251
Kcnma1Ratapical plasma membrane located_inISOKCNMA1 (Homo sapiens)1624291 PMID:10840032RGDPMID:10840032
Kcnma1Ratcaveola located_inIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnma1Ratcaveola located_inISOKCNMA1 (Homo sapiens)1624291 PMID:15703204RGDPMID:15703204
Kcnma1Ratdendrite  IDA 1581583 RGD 
Kcnma1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Kcnma1Ratendoplasmic reticulum located_inISOKcnma1 (Mus musculus)1624291 PMID:17303127RGDPMID:17303127
Kcnma1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Kcnma1Ratexternal side of plasma membrane  IDA 1581583 RGD 
Kcnma1Ratexternal side of plasma membrane located_inISOKcnma1 (Mus musculus)1624291 PMID:17303127RGDPMID:17303127
Kcnma1Ratglutamatergic synapse is_active_inIDA 1581587PMID:11739569SynGO 
Kcnma1Ratglutamatergic synapse is_active_inEXP 1581587PMID:11739569SynGO 
Kcnma1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Kcnma1Ratmembrane located_inIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnma1Ratmembrane located_inISOKCNMA1 (Homo sapiens)1624291 PMID:7573516 and PMID:7877450RGDPMID:7573516 and PMID:7877450
Kcnma1Ratmembrane located_inISOKCNMA1 (Homo sapiens) and UniProtKB:Q12791-71624291 PMID:11880513RGDPMID:11880513
Kcnma1Ratmembrane located_inISOKcnma1 (Mus musculus)1624291 PMID:12388098RGDPMID:12388098
Kcnma1Ratmembrane located_inIEAInterPro:IPR003929 and InterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Kcnma1Ratmonoatomic ion channel complex part_ofIEAUniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
1 to 20 of 37 rows

Molecular Function
1 to 20 of 47 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Kcnma1Ratactin binding enablesIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnma1Ratactin binding enablesISOKCNMA1 (Homo sapiens)1624291 PMID:15703204RGDPMID:15703204
Kcnma1Ratcalcium-activated potassium channel activity  IDA 633136 RGD 
Kcnma1Ratcalcium-activated potassium channel activity enablesIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
Kcnma1Ratcalcium-activated potassium channel activity enablesISOKcnma1 (Mus musculus)1624291MGI:1334203 more ...RGDPMID:10517674 more ...
Kcnma1Ratcalcium-activated potassium channel activity enablesISOKCNMA1 (Homo sapiens) and UniProtKB:Q12791-41624291 PMID:7993625RGDPMID:7993625
Kcnma1Ratcalcium-activated potassium channel activity enablesISOKCNMA1 (Homo sapiens) and UniProtKB:Q12791-71624291 PMID:11880513RGDPMID:11880513
Kcnma1Ratcalcium-activated potassium channel activity enablesISOKCNMA1 (Homo sapiens)1624291 PMID:11245614 more ...RGDPMID:11245614 more ...
Kcnma1Ratcalcium-activated potassium channel activity enablesIDA 633139PMID:10651830UniProt 
Kcnma1Ratcalcium-activated potassium channel activity enablesIMP 405650292PMID:16166559UniProt 
Kcnma1Ratcalcium-activated potassium channel activity enablesIDA 405650221PMID:9403560UniProt 
Kcnma1Ratcalcium-activated potassium channel activity enablesISOKCNMA1 (Canis lupus familiaris)1624291 PMID:8897882RGDPMID:8897882
Kcnma1Ratcalcium-activated potassium channel activity enablesTAS 1600115Reactome:R-RNO-9667806ReactomeReactome:R-RNO-9667806
Kcnma1Ratidentical protein binding  IPIKcnma1 (Rattus norvegicus)1581583homodimerization and homotetramerizationRGD 
Kcnma1Ratidentical protein binding enablesISOKcnma1 (Mus musculus)1624291 PMID:17303127RGDPMID:17303127
Kcnma1Ratidentical protein binding enablesISOKCNMA1 (Homo sapiens) and UniProtKB:Q12791-51624291UniProtKB:Q12791-5 and PMID:20574420RGDPMID:20574420
Kcnma1Ratlarge conductance calcium-activated potassium channel activity  IDA 7205477 RGD 
Kcnma1Ratlarge conductance calcium-activated potassium channel activity enablesIBAMGI:99923 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcnma1Ratlarge conductance calcium-activated potassium channel activity enablesISOKCNMA1 (Homo sapiens)1624291 PMID:15703204RGDPMID:15703204
Kcnma1Ratlarge conductance calcium-activated potassium channel activity enablesIEAUniProtKB:Q12791 and ensembl:ENSP000002866281600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 47 rows


1 to 20 of 38 rows
#
Reference Title
Reference Citation
1. Stimulatory action of internal protons on Slo1 BK channels. Avdonin V, etal., Biophys J. 2003 May;84(5):2969-80.
2. BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Berkefeld H, etal., Science. 2006 Oct 27;314(5799):615-20.
3. Replication study of genome-wide associated SNPs with late-onset Alzheimer's disease. Burns LC, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jun;156B(4):507-12. doi: 10.1002/ajmg.b.31194. Epub 2011 Apr 7.
4. Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Chen M, etal., Mol Neurobiol. 2013 Dec;48(3):794-807. doi: 10.1007/s12035-013-8467-x. Epub 2013 May 8.
5. Steady-state and closed-state inactivation properties of inactivating BK channels. Ding JP and Lingle CJ, Biophys J 2002 May;82(5):2448-65.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Properties of large conductance calcium-activated potassium channels in pyramidal neurons from the hippocampal CA1 region of adult rats. Gong LW, etal., Jpn J Physiol 2001 Dec;51(6):725-31.
8. Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel. Ha TS, etal., Biophys J. 2004 May;86(5):2871-82.
9. Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues. Ha TS, etal., Eur J Biochem 2000 Feb;267(3):910-8.
10. Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. Hu H, etal., J Neurosci. 2001 Dec 15;21(24):9585-97.
11. Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels. Iozzi D, etal., Acta Physiol (Oxf). 2013 Aug;208(4):329-39. doi: 10.1111/apha.12083. Epub 2013 Mar 25.
12. Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels. Jaggar JH, etal., Circ Res. 2005 Oct 14;97(8):805-12. doi: 10.1161/01.RES.0000186180.47148.7b. Epub 2005 Sep 15.
13. Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa. Jing F, etal., J Pharm Pharmacol. 2013 Jun;65(6):847-54. doi: 10.1111/jphp.12041. Epub 2013 Feb 28.
14. Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain. Jo S, etal., J Neurochem. 2005 Sep;94(5):1212-24. Epub 2005 Jul 25.
15. Enhanced K(+) secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K(+) channels (BK; Kcnma1). Kanthesh BM, etal., Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C972-80. doi: 10.1152/ajpcell.00165.2013. Epub 2013 Aug 28.
16. Myelin basic protein as a binding partner and calmodulin adaptor for the BKCa channel. Kim H, etal., Proteomics. 2007 Aug;7(15):2591-602.
17. Regulation of alternative splicing of Slo K+ channels in adrenal and pituitary during the stress-hyporesponsive period of rat development. Lai GJ and McCobb DP, Endocrinology. 2006 Aug;147(8):3961-7. Epub 2006 May 4.
18. Opposing actions of adrenal androgens and glucocorticoids on alternative splicing of Slo potassium channels in bovine chromaffin cells. Lai GJ and McCobb DP, Proc Natl Acad Sci U S A 2002 May 28;99(11):7722-7.
19. Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation. Li M, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19096-101. doi: 10.1073/pnas.1002685107. Epub 2010 Oct 19.
20. Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. Liu G, etal., EMBO J. 2004 Jun 2;23(11):2196-205. Epub 2004 May 13.
1 to 20 of 38 rows
1 to 10 of 10 rows
PMID:7573516   PMID:7687074   PMID:7877450   PMID:7993625   PMID:10517674   PMID:10840032   PMID:11245614   PMID:11278440   PMID:11641143   PMID:11880513   PMID:12388065   PMID:12388098  
PMID:12454985   PMID:12547730   PMID:12949219   PMID:12952984   PMID:14523450   PMID:15049854   PMID:15184377   PMID:15194823   PMID:15328414   PMID:15703204   PMID:15827347   PMID:15867178  
PMID:16081418   PMID:16306267   PMID:16341213   PMID:16566008   PMID:16763026   PMID:16845385   PMID:16873365   PMID:16997278   PMID:17074442   PMID:17097837   PMID:17122062   PMID:17135251  
PMID:17150299   PMID:17166942   PMID:17259072   PMID:17303127   PMID:17468198   PMID:17701422   PMID:17706472   PMID:18079116   PMID:18180950   PMID:18250327   PMID:18458941   PMID:18562499  
PMID:18573811   PMID:18953570   PMID:19168436   PMID:19651031   PMID:19940072   PMID:20574420   PMID:20713546   PMID:20817829   PMID:20933547   PMID:20936291   PMID:20938677   PMID:21079807  
PMID:21158046   PMID:21186374   PMID:21325638   PMID:21900688   PMID:22052159   PMID:22131374   PMID:22322970   PMID:22350354   PMID:22555843   PMID:22570490   PMID:22633934   PMID:22808126  
PMID:22871113   PMID:22882938   PMID:23376485   PMID:23646921   PMID:23872879   PMID:23937098   PMID:24397812   PMID:24462688   PMID:24602615   PMID:24729485   PMID:24836752   PMID:25139746  
PMID:25192641   PMID:25371198   PMID:25481230   PMID:25494655   PMID:25661478   PMID:25864652   PMID:26277265   PMID:26755740   PMID:26791489   PMID:26823461   PMID:27329042   PMID:28075010  
PMID:28665272   PMID:28672269   PMID:29508439   PMID:29558628   PMID:30612588   PMID:30991005   PMID:31152168   PMID:32967457   PMID:33452855   PMID:34267344   PMID:34271438   PMID:35043645  
PMID:35489424   PMID:37598353  
1 to 10 of 10 rows



Kcnma1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815351,065 - 1,057,117 (+)NCBIGRCr8
mRatBN7.215302,480 - 1,007,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15302,214 - 1,001,198 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15309,515 - 1,014,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0151,696,105 - 2,401,327 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015308,241 - 1,013,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015344,204 - 1,048,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15344,360 - 1,047,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015339,100 - 1,037,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415575,136 - 950,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115322,288 - 950,273NCBI
Celera153,556,267 - 4,246,392 (-)NCBICelera
Cytogenetic Map15p16NCBI
KCNMA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381076,869,602 - 77,637,808 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1076,869,601 - 77,638,369 (-)EnsemblGRCh38hg38GRCh38
GRCh371078,629,360 - 79,397,566 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361078,299,366 - 79,067,583 (-)NCBINCBI36Build 36hg18NCBI36
Build 341078,314,640 - 79,067,583NCBI
Celera1071,914,113 - 72,684,182 (-)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1072,624,294 - 73,391,824 (-)NCBIHuRef
CHM1_11078,911,952 - 79,680,009 (-)NCBICHM1_1
T2T-CHM13v2.01077,738,326 - 78,506,527 (-)NCBIT2T-CHM13v2.0
Kcnma1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391423,342,356 - 24,055,173 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1423,339,499 - 24,064,559 (-)EnsemblGRCm39 Ensembl
GRCm381423,292,288 - 24,005,110 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1423,289,431 - 24,014,491 (-)EnsemblGRCm38mm10GRCm38
MGSCv371424,117,983 - 24,823,427 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361422,088,573 - 22,792,482 (-)NCBIMGSCv36mm8
Celera1419,676,577 - 20,379,488 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1412.92NCBI
Kcnma1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543714,749,914 - 15,454,028 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543714,749,808 - 15,457,274 (+)NCBIChiLan1.0ChiLan1.0
KCNMA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2889,019,281 - 89,786,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11089,024,606 - 89,791,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01073,391,297 - 74,158,488 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11076,053,915 - 76,820,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1076,062,047 - 76,820,644 (-)Ensemblpanpan1.1panPan2
KCNMA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1426,844,250 - 27,338,271 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl426,844,250 - 27,555,776 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha426,970,672 - 27,681,029 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0427,145,564 - 27,857,706 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl427,143,848 - 27,857,493 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1427,020,780 - 27,731,400 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0427,220,327 - 27,931,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0427,571,588 - 28,283,070 (-)NCBIUU_Cfam_GSD_1.0
Kcnma1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721353,507,382 - 54,220,539 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365212,000,109 - 2,705,365 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365212,000,113 - 2,706,010 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNMA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1479,352,005 - 80,106,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11479,345,382 - 80,106,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21485,796,582 - 85,996,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21486,640,231 - 86,640,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21486,138,921 - 86,358,528 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNMA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1953,727,790 - 54,557,252 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl954,182,910 - 54,554,716 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604814,223,140 - 14,987,512 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnma1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475410,153,809 - 10,885,079 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475410,152,635 - 10,885,239 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Kcnma1
3618 total Variants

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:96
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000065542, ENSRNOT00000066928
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat

D15Rat73  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215821,049 - 821,287 (+)MAPPERmRatBN7.2
Rnor_6.015873,565 - 873,802NCBIRnor6.0
Rnor_5.015862,384 - 862,621UniSTSRnor5.0
RGSC_v3.415766,501 - 766,738UniSTSRGSC3.4
RGSC_v3.415766,261 - 766,899RGDRGSC3.4
RGSC_v3.115766,502 - 766,738RGD
Celera153,729,257 - 3,729,494UniSTS
RH 3.4 Map1534.9RGD
RH 3.4 Map1534.9UniSTS
RH 2.0 Map150.0RGD
SHRSP x BN Map153.9298RGD
FHH x ACI Map150.04RGD
Cytogenetic Map15p16UniSTS
D15Rat108  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr815666,410 - 666,568 (+)Marker Load Pipeline
mRatBN7.215616,969 - 617,127 (+)MAPPERmRatBN7.2
Rnor_6.015668,009 - 668,166NCBIRnor6.0
Rnor_5.015658,019 - 658,176UniSTSRnor5.0
RGSC_v3.415557,527 - 557,682RGDRGSC3.4
RGSC_v3.415557,528 - 557,685UniSTSRGSC3.4
RGSC_v3.115557,527 - 557,682RGD
Celera153,933,166 - 3,933,327UniSTS
FHH x ACI Map150.0UniSTS
FHH x ACI Map150.0RGD
Cytogenetic Map15p16UniSTS
D15Rat135  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr815617,973 - 618,178 (+)Marker Load Pipeline
mRatBN7.215568,533 - 568,738 (+)MAPPERmRatBN7.2
Rnor_6.015613,195 - 613,399NCBIRnor6.0
Rnor_5.015603,180 - 603,384UniSTSRnor5.0
RGSC_v3.415506,685 - 506,890RGDRGSC3.4
RGSC_v3.415506,686 - 506,890UniSTSRGSC3.4
RGSC_v3.115506,487 - 507,058RGD
Celera153,981,511 - 3,981,715UniSTS
RH 2.0 Map150.0RGD
SHRSP x BN Map155.0199RGD
Cytogenetic Map15p16UniSTS
U09383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2151,000,025 - 1,000,132 (+)MAPPERmRatBN7.2
Rnor_6.0151,047,677 - 1,047,783NCBIRnor6.0
Rnor_5.0151,035,933 - 1,036,039UniSTSRnor5.0
RGSC_v3.415949,103 - 949,209UniSTSRGSC3.4
Celera153,557,333 - 3,557,439UniSTS
Cytogenetic Map15p16UniSTS
D14Mit208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215874,983 - 875,093 (+)MAPPERmRatBN7.2
Rnor_6.015927,494 - 927,603NCBIRnor6.0
Rnor_5.015916,313 - 916,422UniSTSRnor5.0
RGSC_v3.415820,431 - 820,540UniSTSRGSC3.4
Celera153,675,470 - 3,675,579UniSTS
Cytogenetic Map15p16UniSTS
BE113518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215355,078 - 355,236 (+)MAPPERmRatBN7.2
Rnor_6.015399,231 - 399,388NCBIRnor6.0
Rnor_5.015391,958 - 392,115UniSTSRnor5.0
RGSC_v3.415375,345 - 375,502UniSTSRGSC3.4
Celera154,193,257 - 4,193,414UniSTS
RH 3.4 Map1528.9UniSTS
Cytogenetic Map15p16UniSTS
WI-18797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215990,952 - 991,117 (+)MAPPERmRatBN7.2
Rnor_6.0151,038,604 - 1,038,768NCBIRnor6.0
Rnor_5.0151,026,860 - 1,027,024UniSTSRnor5.0
RGSC_v3.415940,030 - 940,194UniSTSRGSC3.4
Celera153,566,352 - 3,566,516UniSTS
Cytogenetic Map15p16UniSTS
BF386160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215711,476 - 711,641 (+)MAPPERmRatBN7.2
Rnor_6.015763,072 - 763,236NCBIRnor6.0
Rnor_5.015751,868 - 752,032UniSTSRnor5.0
RGSC_v3.415656,277 - 656,441UniSTSRGSC3.4
Celera153,838,910 - 3,839,074UniSTS
RH 3.4 Map1535.0UniSTS
Cytogenetic Map15p16UniSTS
BE101789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215530,055 - 530,205 (+)MAPPERmRatBN7.2
Rnor_6.015575,219 - 575,368NCBIRnor6.0
Rnor_5.015564,821 - 564,970UniSTSRnor5.0
Celera154,020,245 - 4,020,394UniSTS
RH 3.4 Map1531.6UniSTS
Cytogenetic Map15p16UniSTS
BF405369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215313,741 - 313,922 (+)MAPPERmRatBN7.2
Rnor_6.015355,864 - 356,044NCBIRnor6.0
Rnor_5.015350,760 - 350,940UniSTSRnor5.0
RGSC_v3.415333,999 - 334,179UniSTSRGSC3.4
Celera154,234,546 - 4,234,726UniSTS
RH 3.4 Map1528.9UniSTS
Cytogenetic Map15p16UniSTS
Kcnma1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215871,373 - 871,451 (+)MAPPERmRatBN7.2
Rnor_6.015923,884 - 923,961NCBIRnor6.0
Rnor_5.015912,703 - 912,780UniSTSRnor5.0
RGSC_v3.415816,821 - 816,898UniSTSRGSC3.4
Celera153,679,111 - 3,679,188UniSTS
Cytogenetic Map15p16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 66 65 34 25 34 6 191 95 93 45 60 31


1 to 30 of 56 rows
RefSeq Transcripts NM_001393699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 56 rows

Ensembl Acc Id: ENSRNOT00000065542   ⟹   ENSRNOP00000058962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,414 - 1,001,198 (+)Ensembl
Rnor_6.0 Ensembl15344,685 - 1,047,625 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066928   ⟹   ENSRNOP00000061684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,585 - 1,000,263 (+)Ensembl
Rnor_6.0 Ensembl15344,710 - 1,047,914 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077671   ⟹   ENSRNOP00000074702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,214 - 1,000,252 (+)Ensembl
Rnor_6.0 Ensembl15344,360 - 1,047,903 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091318   ⟹   ENSRNOP00000071652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15497,821 - 1,000,263 (+)Ensembl
Rnor_6.0 Ensembl15675,085 - 1,047,956 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096488   ⟹   ENSRNOP00000090930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,414 - 1,001,198 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105174   ⟹   ENSRNOP00000086150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,414 - 1,001,198 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109388   ⟹   ENSRNOP00000096569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15497,821 - 991,893 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109865   ⟹   ENSRNOP00000082424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15302,214 - 991,893 (+)Ensembl
RefSeq Acc Id: NM_001393699   ⟹   NP_001380628
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,925 - 1,057,117 (+)NCBI
mRatBN7.215302,480 - 1,007,675 (+)NCBI
RefSeq Acc Id: NM_001393700   ⟹   NP_001380629
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,925 - 1,057,117 (+)NCBI
mRatBN7.215302,480 - 1,007,675 (+)NCBI
RefSeq Acc Id: NM_001393701   ⟹   NP_001380630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,925 - 1,057,117 (+)NCBI
mRatBN7.215302,480 - 1,007,675 (+)NCBI
RefSeq Acc Id: NM_031828   ⟹   NP_114016
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,925 - 1,057,117 (+)NCBI
mRatBN7.215302,480 - 1,007,675 (+)NCBI
Rnor_6.015344,204 - 1,048,849 (+)NCBI
Rnor_5.015339,100 - 1,037,105 (+)NCBI
RGSC_v3.415575,136 - 950,275 (+)RGD
Celera153,556,267 - 4,246,392 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274699   ⟹   XP_063130769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274700   ⟹   XP_063130770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274701   ⟹   XP_063130771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,246 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274702   ⟹   XP_063130772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274703   ⟹   XP_063130773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274704   ⟹   XP_063130774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,245 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274705   ⟹   XP_063130775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,245 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274706   ⟹   XP_063130776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274707   ⟹   XP_063130777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,244 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274708   ⟹   XP_063130778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,247 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274709   ⟹   XP_063130779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,246 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274710   ⟹   XP_063130780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,246 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274711   ⟹   XP_063130781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,248 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274712   ⟹   XP_063130782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274713   ⟹   XP_063130783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274714   ⟹   XP_063130784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,248 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274715   ⟹   XP_063130785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,247 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274716   ⟹   XP_063130786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274717   ⟹   XP_063130787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,249 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274718   ⟹   XP_063130788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,252 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274719   ⟹   XP_063130789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,252 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274720   ⟹   XP_063130790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,249 - 1,042,711 (+)NCBI
RefSeq Acc Id: XM_063274721   ⟹   XP_063130791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,251 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274722   ⟹   XP_063130792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274723   ⟹   XP_063130793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274724   ⟹   XP_063130794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,049,694 (+)NCBI
RefSeq Acc Id: XM_063274725   ⟹   XP_063130795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,252 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274726   ⟹   XP_063130796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,084 - 596,200 (+)NCBI
RefSeq Acc Id: XM_063274727   ⟹   XP_063130797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,179 - 759,238 (+)NCBI
RefSeq Acc Id: XM_063274728   ⟹   XP_063130798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,065 - 382,168 (+)NCBI
RefSeq Acc Id: XM_063274729   ⟹   XP_063130799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,248 - 1,057,117 (+)NCBI
RefSeq Acc Id: XM_063274730   ⟹   XP_063130800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815351,250 - 1,042,711 (+)NCBI
1 to 30 of 70 rows
Protein RefSeqs NP_001380628 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380629 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380630 (Get FASTA)   NCBI Sequence Viewer  
  NP_114016 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130769 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130770 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130771 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130772 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130773 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130774 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130775 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130776 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130777 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130778 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130779 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130780 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130781 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130782 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130783 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130784 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130785 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130786 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130787 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130788 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130789 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130790 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130791 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130792 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130793 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130794 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 70 rows
1 to 5 of 44 rows
1 to 5 of 44 rows
RefSeq Acc Id: NP_114016   ⟸   NM_031828
- Peptide Label: isoform 1
- UniProtKB: Q9WUI3 (UniProtKB/Swiss-Prot),   Q7TQ57 (UniProtKB/Swiss-Prot),   Q7TQ56 (UniProtKB/Swiss-Prot),   Q7TQ55 (UniProtKB/Swiss-Prot),   Q7TMZ8 (UniProtKB/Swiss-Prot),   Q7TMZ7 (UniProtKB/Swiss-Prot),   Q62976 (UniProtKB/Swiss-Prot),   O88659 (UniProtKB/Swiss-Prot),   O55180 (UniProtKB/Swiss-Prot),   O08626 (UniProtKB/Swiss-Prot),   A0A8I6A598 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058962   ⟸   ENSRNOT00000065542
Ensembl Acc Id: ENSRNOP00000074702   ⟸   ENSRNOT00000077671
Ensembl Acc Id: ENSRNOP00000071652   ⟸   ENSRNOT00000091318
Ensembl Acc Id: ENSRNOP00000061684   ⟸   ENSRNOT00000066928
Name Modeler Protein Id AA Range Protein Structure
AF-Q62976-F1-model_v2 AlphaFold Q62976 1-1209 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699549
Promoter ID:EPDNEW_R10067
Type:multiple initiation site
Name:Kcnma1_1
Description:potassium calcium-activated channel subfamily M alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.015344,718 - 344,778EPDNEW


1 to 40 of 70 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-14611 BioCyc
Ensembl Genes ENSRNOG00000005985 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065542 ENTREZGENE
  ENSRNOT00000065542.5 UniProtKB/TrEMBL
  ENSRNOT00000066928 ENTREZGENE
  ENSRNOT00000066928.4 UniProtKB/Swiss-Prot
  ENSRNOT00000077671.2 UniProtKB/TrEMBL
  ENSRNOT00000091318 ENTREZGENE
  ENSRNOT00000091318.2 UniProtKB/TrEMBL
  ENSRNOT00000096488.1 UniProtKB/TrEMBL
  ENSRNOT00000105174 ENTREZGENE
  ENSRNOT00000105174.1 UniProtKB/TrEMBL
  ENSRNOT00000109388 ENTREZGENE
  ENSRNOT00000109388.1 UniProtKB/TrEMBL
  ENSRNOT00000109865 ENTREZGENE
  ENSRNOT00000109865.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_BK_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_Slo-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slo-like_RCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slowpoke-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83731 UniProtKB/Swiss-Prot
NCBI Gene 83731 ENTREZGENE
PANTHER CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10027:SF28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BK_channel_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slo-like_RCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slowpoke_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnma1 PhenoGen
PRINTS BKCHANNELA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RCK_N UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005985 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K104_RAT UniProtKB/TrEMBL
1 to 40 of 70 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnma1  potassium calcium-activated channel subfamily M alpha 1  Kcnma1  potassium channel, calcium activated large conductance subfamily M alpha, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnma1  potassium channel, calcium activated large conductance subfamily M alpha, member 1  Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1  LOC498438  similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1  Data merged from RGD:1591969 737654 PROVISIONAL
2006-11-20 LOC498438  similar to potassium large conductance calcium-activated channel, subfamily M, alpha member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Kcnma1  potassium large conductance calcium-activated channel, subfamily M, alpha member 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnma1  potassium large conductance calcium-activated channel, ubfamily M, alpha member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in adrenal chromaffin cells 625439
gene_function potassium large conductance calcium-activated channel 625439
gene_process increases repetitive firing of chromaffin cells by minimizing action potential duration and speeding recovery of sodium channels from inactivation 625439
gene_regulation production of splice variants are differentially regulated by glucocorticoids and androgens in adrenal chromaffin cells 625439
gene_regulation channel acitivity is increased in a NO-mediated fashion 633138