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- Name help_outline dimethyl sulfoxide Identifier CHEBI:28262 (Beilstein: 506008; CAS: 67-68-5) help_outline Charge 0 Formula C2H6OS InChIKeyhelp_outline IAZDPXIOMUYVGZ-UHFFFAOYSA-N SMILEShelp_outline CS(C)=O 2D coordinates Mol file for the small molecule Search links Involved in 9 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline menaquinol-8 Identifier CHEBI:61684 Charge 0 Formula C51H74O2 InChIKeyhelp_outline OIEZRVBFVPGODT-WQWYCSGDSA-N SMILEShelp_outline CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\Cc1c(C)c(O)c2ccccc2c1O 2D coordinates Mol file for the small molecule Search links Involved in 19 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline dimethyl sulfide Identifier CHEBI:17437 (Beilstein: 1696847; CAS: 75-18-3) help_outline Charge 0 Formula C2H6S InChIKeyhelp_outline QMMFVYPAHWMCMS-UHFFFAOYSA-N SMILEShelp_outline CSC 2D coordinates Mol file for the small molecule Search links Involved in 11 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline H2O Identifier CHEBI:15377 (Beilstein: 3587155; CAS: 7732-18-5) help_outline Charge 0 Formula H2O InChIKeyhelp_outline XLYOFNOQVPJJNP-UHFFFAOYSA-N SMILEShelp_outline [H]O[H] 2D coordinates Mol file for the small molecule Search links Involved in 6,048 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
- Name help_outline menaquinone-8 Identifier CHEBI:44027 (CAS: 523-38-6) help_outline Charge 0 Formula C51H72O2 InChIKeyhelp_outline LXKDFTDVRVLXFY-WQWYCSGDSA-N SMILEShelp_outline CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=C(C)C(=O)c2ccccc2C1=O 2D coordinates Mol file for the small molecule Search links Involved in 18 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Cross-references
| RHEA:29203 | RHEA:29204 | RHEA:29205 | RHEA:29206 | |
|---|---|---|---|---|
| Reaction direction help_outline | undefined | left-to-right | right-to-left | bidirectional |
| UniProtKB help_outline |
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Publications
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Multiple pathways of electron transfer in dimethyl sulfoxide reductase of Escherichia coli.
Trieber C.A., Rothery R.A., Weiner J.H.
The catalytic subunit of dimethyl sulfoxide (Me2SO) reductase, DmsA, contains six blocks of sequence that are homologous to other members of the superfamily of prokaryotic molybdoenzymes. The amino-terminal block contains 5 conserved residues (Cys38, Cys42, Cys75, Lys28, and Arg77). Site-directed ... >> More
The catalytic subunit of dimethyl sulfoxide (Me2SO) reductase, DmsA, contains six blocks of sequence that are homologous to other members of the superfamily of prokaryotic molybdoenzymes. The amino-terminal block contains 5 conserved residues (Cys38, Cys42, Cys75, Lys28, and Arg77). Site-directed mutagenesis of these residues did not alter membrane localization but in some cases less enzyme accumulated. The activity of Me2SO reductase was monitored by measuring Me2SO-dependent anaerobic growth, benzyl viologen, or dimethylnaphthoquinol oxidase activity, and using a quinol pool-coupling assay. Only Cys75 and Lys28 mutant enzymes were able to support anaerobic growth with Me2SO suggesting a critical role for Cys38, Cys42, and Arg77. Benzyl viologen oxidase activity was retained in the mutants although with reduced efficiency in Cys42-Ser. Electron transport with dimethylnaphthoquinol was reduced in Cys38-Ser, Cys42-Ser, and Cys75-Ser and almost totally eliminated in the Arg77-Ser mutant. Cys38-Ser, Cys42-Ser, and Arg77-Ser were unable to support quinol oxidation although electron transfer from the quinol pool to the [Fe-S] centers in DmsB was normal. These results indicate that the amino-terminal region is involved in functional electron transfer from the quinol pool to Me2SO and that electrons from benzyl viologen, dimethylnaphthoquinol, and menaquinol may follow different paths within the catalytic subunit. << Less
J. Biol. Chem. 269:7103-7109(1994) [PubMed] [EuropePMC]
This publication is cited by 2 other entries.