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  up:modified "2024-03-27"^^xsd:date ;
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    <http://purl.uniprot.org/proteomes/UP000000625#Chromosome> .
citation:3040739 rdf:type up:Journal_Citation ;
  up:title "Primary structure of the Escherichia coli folC gene and its folylpolyglutamate synthetase-dihydrofolate synthetase product and regulation of expression by an upstream gene." ;
  up:author "Bognar A.L." ,
    "Osborne C." ,
    "Shane B." ;
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  up:date "1987"^^xsd:gYear ;
  up:name "J. Biol. Chem." ;
  up:volume "262" ;
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citation:3040734 rdf:type up:Journal_Citation ;
  up:title "The hisT-purF region of the Escherichia coli K-12 chromosome. Identification of additional genes of the hisT and purF operons." ;
  up:author "Nonet M.L." ,
    "Marvel C.C." ,
    "Tolan D.R." ;
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  up:name "J. Biol. Chem." ;
  up:volume "262" ;
  up:pages "12209-12217" .
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  up:title "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." ;
  up:author "Yamamoto Y." ,
    "Aiba H." ,
    "Baba T." ,
    "Hayashi K." ,
    "Inada T." ,
    "Isono K." ,
    "Itoh T." ,
    "Kimura S." ,
    "Kitagawa M." ,
    "Makino K." ,
    "Miki T." ,
    "Mitsuhashi N." ,
    "Mizobuchi K." ,
    "Mori H." ,
    "Nakade S." ,
    "Nakamura Y." ,
    "Nashimoto H." ,
    "Oshima T." ,
    "Oyama S." ,
    "Saito N." ,
    "Sampei G." ,
    "Satoh Y." ,
    "Sivasundaram S." ,
    "Tagami H." ,
    "Takahashi H." ,
    "Takeda J." ,
    "Takemoto K." ,
    "Uehara K." ,
    "Wada C." ,
    "Yamagata S." ,
    "Horiuchi T." ;
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  dcterms:identifier "doi:10.1093/dnares/4.2.91" ;
  up:date "1997"^^xsd:gYear ;
  up:name "DNA Res." ;
  up:volume "4" ;
  up:pages "91-113" .
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citation:9278503 rdf:type up:Journal_Citation ;
  up:title "The complete genome sequence of Escherichia coli K-12." ;
  up:author "Blattner F.R." ,
    "Plunkett G. III" ,
    "Bloch C.A." ,
    "Perna N.T." ,
    "Burland V." ,
    "Riley M." ,
    "Collado-Vides J." ,
    "Glasner J.D." ,
    "Rode C.K." ,
    "Mayhew G.F." ,
    "Gregor J." ,
    "Davis N.W." ,
    "Kirkpatrick H.A." ,
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    "Rose D.J." ,
    "Mau B." ,
    "Shao Y." ;
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citation:16738553 rdf:type up:Journal_Citation ;
  up:title "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." ;
  up:author "Hayashi K." ,
    "Morooka N." ,
    "Yamamoto Y." ,
    "Fujita K." ,
    "Isono K." ,
    "Choi S." ,
    "Ohtsubo E." ,
    "Baba T." ,
    "Wanner B.L." ,
    "Mori H." ,
    "Horiuchi T." ;
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  up:name "Mol. Syst. Biol." ;
  up:volume "2" ;
  up:pages "E1-E5" .
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citation:2985605 rdf:type up:Journal_Citation ;
  up:title "Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product." ;
  up:author "Bognar A.L." ,
    "Osborne C." ,
    "Shane B." ,
    "Singer S.C." ,
    "Ferone R." ;
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  dcterms:identifier "doi:10.1016/s0021-9258(18)89069-x" ;
  up:date "1985"^^xsd:gYear ;
  up:name "J. Biol. Chem." ;
  up:volume "260" ;
  up:pages "5625-5630" .
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citation:1989505 rdf:type up:Journal_Citation ;
  up:title "Mutagenesis of the folC gene encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli." ;
  up:author "Kimlova L.J." ,
    "Pyne C." ,
    "Keshavjee K." ,
    "Huy J." ,
    "Beebakhee G." ,
    "Bognar A.L." ;
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  up:date "1991"^^xsd:gYear ;
  up:name "Arch. Biochem. Biophys." ;
  up:volume "284" ;
  up:pages "9-16" .
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citation:18232714 rdf:type up:Journal_Citation ;
  up:title "Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site." ;
  up:author "Sheng Y." ,
    "Khanam N." ,
    "Tsaksis Y." ,
    "Shi X.M." ,
    "Lu Q.S." ,
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    "Vincent S." ,
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  rdf:object "Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives." ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> ,
    <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> ,
    <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<P08192#SIP8CF9950376AE9A8F> rdf:type up:Catalytic_Activity_Annotation ;
  up:catalyticActivity <P08192#SIP4CF922B74B6693B3> .
<#_2764D99C22133C87_90BE42743953BDE0_67A91C57F06A4A36> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIP8CF9950376AE9A8F> ;
  rdf:predicate up:catalyticActivity ;
  rdf:object <P08192#SIP4CF922B74B6693B3> ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> ,
    <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> ,
    <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<P08192#SIP4CF922B74B6693B3> rdf:type up:Catalytic_Activity ;
  up:catalyzedReaction <http://rdf.rhea-db.org/23584> ;
  up:enzymeClass enzyme:6.3.2.12 .
<P08192#SIPF5F6AC8350ED6A95> rdf:type up:Catalytic_Activity_Annotation ;
  up:catalyticActivity <P08192#SIPC68688FFB24C05E7> .
<#_4EAB6901FA1A07D6_90BE42743953BDE0_1F3978C514A7B961> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF5F6AC8350ED6A95> ;
  rdf:predicate up:catalyticActivity ;
  rdf:object <P08192#SIPC68688FFB24C05E7> ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<P08192#SIPC68688FFB24C05E7> rdf:type up:Catalytic_Activity ;
  up:catalyzedReaction <http://rdf.rhea-db.org/10580> ;
  up:enzymeClass enzyme:6.3.2.17 .
<P08192#SIPBA37AA7012E2F7A4> rdf:type up:Catalytic_Activity_Annotation ;
  up:catalyticActivity <P08192#SIP42610C25786C61D8> .
<#_7527B5D1D2F74322_90BE42743953BDE0_A03FB57CF34C5B1A> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPBA37AA7012E2F7A4> ;
  rdf:predicate up:catalyticActivity ;
  rdf:object <P08192#SIP42610C25786C61D8> ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> ,
    <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<P08192#SIP42610C25786C61D8> rdf:type up:Catalytic_Activity ;
  up:catalyzedReaction <http://rdf.rhea-db.org/51904> ;
  up:enzymeClass enzyme:6.3.2.17 .
<P08192#SIP774749DE779BC185> rdf:type up:Catalytic_Activity_Annotation ;
  up:catalyticActivity <P08192#SIPEBF4F0310C6019F1> .
<#_1D3D7FADF752AD62_90BE42743953BDE0_07BA12CA080043A5> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIP774749DE779BC185> ;
  rdf:predicate up:catalyticActivity ;
  rdf:object <P08192#SIPEBF4F0310C6019F1> ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<P08192#SIPEBF4F0310C6019F1> rdf:type up:Catalytic_Activity ;
  up:catalyzedReaction <http://rdf.rhea-db.org/51912> ;
  up:enzymeClass enzyme:6.3.2.17 .
<P08192#SIP708647E33556F76E> rdf:type up:Cofactor_Annotation ;
  rdfs:comment "Binds 2 Mg(2+) ions per subunit." ;
  up:cofactor <http://purl.obolibrary.org/obo/CHEBI_18420> .
<#_BDD6DE422E846C22_rdfs.comment_EA5071825AA0539B> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIP708647E33556F76E> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Binds 2 Mg(2+) ions per subunit." ;
  up:attribution <P08192#attribution-432C5DEB00CD656D1C02890631411D3F> .
<#_BDD6DE422E846C22_up.cofactor_BA34A339165EE263> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIP708647E33556F76E> ;
  rdf:predicate up:cofactor ;
  rdf:object <http://purl.obolibrary.org/obo/CHEBI_18420> ;
  up:attribution <P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> .
<P08192#SIPF338B6562C8CCC16> rdf:type up:Kinetics_Annotation ;
  rdfs:comment "kcat is 25 min(-1) with 7,8-dihydropteroate as substrate (at 30 degrees Celsius)." ;
  up:measuredAffinity "0.6 uM for 7,8-dihydropteroate" ,
    "6.9 uM for ATP (in the assay for DHFS activity)" ,
    "3.9 mM for glutamate (in the assay for DHFS activity)" ,
    "0.6 uM for (6RS)-10-formyl-tetrahydropteroyl-gamma-Glu" ,
    "66.5 uM for ATP (in the assay for FPGS activity)" ,
    "333 uM for glutamate (in the assay for FPGS activity)" ,
    "0.9 uM for 7,8-dihydropteroate" ,
    "10 uM for ATP (in the assay for DHFS activity)" ,
    "2.8 mM for glutamate (in the assay for DHFS activity)" ,
    "17 uM for 10-formyl-tetrahydropteroyl-gamma-Glu" ,
    "54 uM for ATP (in the assay for FPGS activity)" ,
    "300 uM for glutamate (in the assay for FPGS activity)" ,
    "6.3 uM for 7,8-dihydropteroate" ,
    "50 uM for 5,10-methylenetetrahydrofolate" ,
    "50 uM for tetrahydrofolate" ,
    "1.4 uM for tetrahydrofolate diglutamate" ;
  up:measuredActivity "1.1 umol/h/mg enzyme for DHFS activity" ,
    "4.1 umol/h/mg enzyme for FPGS activity with 10-formyl-tetrahydropteroyl-gamma-Glu as substrate" ,
    "415 umol/h/mg enzyme for FPGS activity with tetrahydrofolate as substrate" ,
    "380 umol/h/mg enzyme for FPGS activity with tetrahydrofolate diglutamate as substrate" ,
    "13 umol/h/mg enzyme for DHFS activity" .
<#_2C2CA6148446CD9F_rdfs.comment_73414A5CFC9F92B9> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate rdfs:comment ;
  rdf:object "kcat is 25 min(-1) with 7,8-dihydropteroate as substrate (at 30 degrees Celsius)." ;
  up:attribution <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<#_2C2CA6148446CD9F_up.measuredAffinity_FAF90F54F9483D74> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "0.6 uM for 7,8-dihydropteroate" ;
  up:attribution <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<#_2C2CA6148446CD9F_up.measuredAffinity_EA7CA9CC5098F6CE> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "6.9 uM for ATP (in the assay for DHFS activity)" ;
  up:attribution <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<#_2C2CA6148446CD9F_up.measuredAffinity_573509BB2B51C5A4> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "3.9 mM for glutamate (in the assay for DHFS activity)" ;
  up:attribution <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<#_2C2CA6148446CD9F_up.measuredAffinity_7DCB3592A75F5B4B> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "0.6 uM for (6RS)-10-formyl-tetrahydropteroyl-gamma-Glu" ;
  up:attribution <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<#_2C2CA6148446CD9F_up.measuredAffinity_D1FD8E9B2B08DBDA> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "66.5 uM for ATP (in the assay for FPGS activity)" ;
  up:attribution <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<#_2C2CA6148446CD9F_up.measuredAffinity_5B5D35DAB75445A4> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "333 uM for glutamate (in the assay for FPGS activity)" ;
  up:attribution <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<#_2C2CA6148446CD9F_up.measuredAffinity_F3BB1CCA1D49ACBA> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "0.9 uM for 7,8-dihydropteroate" ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<#_2C2CA6148446CD9F_up.measuredAffinity_0C46DB8B188489F9> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "10 uM for ATP (in the assay for DHFS activity)" ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<#_2C2CA6148446CD9F_up.measuredAffinity_12034699B7373C27> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "2.8 mM for glutamate (in the assay for DHFS activity)" ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<#_2C2CA6148446CD9F_up.measuredAffinity_224649CEAA5DF477> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "17 uM for 10-formyl-tetrahydropteroyl-gamma-Glu" ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<#_2C2CA6148446CD9F_up.measuredAffinity_F462609DE29391F4> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "54 uM for ATP (in the assay for FPGS activity)" ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<#_2C2CA6148446CD9F_up.measuredAffinity_1C8A5E6364BB1311> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "300 uM for glutamate (in the assay for FPGS activity)" ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<#_2C2CA6148446CD9F_up.measuredAffinity_CEC7F0C55134349E> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "6.3 uM for 7,8-dihydropteroate" ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<#_2C2CA6148446CD9F_up.measuredAffinity_ED4089D90E26A202> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "50 uM for 5,10-methylenetetrahydrofolate" ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<#_2C2CA6148446CD9F_up.measuredAffinity_E824A6798E196634> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "50 uM for tetrahydrofolate" ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<#_2C2CA6148446CD9F_up.measuredAffinity_4794E01B0108C412> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredAffinity ;
  rdf:object "1.4 uM for tetrahydrofolate diglutamate" ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<#_2C2CA6148446CD9F_up.measuredActivity_9F9DC7E38900E79D> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredActivity ;
  rdf:object "1.1 umol/h/mg enzyme for DHFS activity" ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<#_2C2CA6148446CD9F_up.measuredActivity_5114D83038D5CC1C> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredActivity ;
  rdf:object "4.1 umol/h/mg enzyme for FPGS activity with 10-formyl-tetrahydropteroyl-gamma-Glu as substrate" ;
  up:attribution <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<#_2C2CA6148446CD9F_up.measuredActivity_4B691FD4019A658C> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredActivity ;
  rdf:object "415 umol/h/mg enzyme for FPGS activity with tetrahydrofolate as substrate" ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<#_2C2CA6148446CD9F_up.measuredActivity_E169003DA8534B04> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredActivity ;
  rdf:object "380 umol/h/mg enzyme for FPGS activity with tetrahydrofolate diglutamate as substrate" ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<#_2C2CA6148446CD9F_up.measuredActivity_49A42173170A632F> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIPF338B6562C8CCC16> ;
  rdf:predicate up:measuredActivity ;
  rdf:object "13 umol/h/mg enzyme for DHFS activity" ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<P08192#SIP209F6458D81AC36D> rdf:type up:Pathway_Annotation ;
  rdfs:seeAlso <http://purl.uniprot.org/unipathway/399.77.64.157> .
<#_kb.P08192_up.annotation_CF600098E85D2C05> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP209F6458D81AC36D> ;
  up:attribution <P08192#attribution-DF5229331033C3EE791E216E7A28B8B2> .
<P08192#SIPDE3B490CEC3BB44E> rdf:type up:Pathway_Annotation ;
  rdfs:seeAlso <http://purl.uniprot.org/unipathway/399.850> .
<#_kb.P08192_up.annotation_2F27A14F80212FA9> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPDE3B490CEC3BB44E> ;
  up:attribution <P08192#attribution-DF5229331033C3EE791E216E7A28B8B2> .
<P08192#SIP0BDB5C289D009C3A> rdf:type up:Subunit_Annotation ;
  rdfs:comment "Monomer." .
<#_47A9046C54BD59F9_rdfs.comment_Monomer.> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIP0BDB5C289D009C3A> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Monomer." ;
  up:attribution <P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> .
<P08192#SIP6CE426F692794B3C> rdf:type up:Domain_Annotation ;
  rdfs:comment "The N-terminal domain alone (residues 1-287) is sufficient to bind both tetrahydrofolate and dihydropteroate with the same affinity as the intact enzyme, but is not able to bind ATP and has no enzymatic activity." .
<#_1E63D6777618B1B4_rdfs.comment_F9715C9733695FD2> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIP6CE426F692794B3C> ;
  rdf:predicate rdfs:comment ;
  rdf:object "The N-terminal domain alone (residues 1-287) is sufficient to bind both tetrahydrofolate and dihydropteroate with the same affinity as the intact enzyme, but is not able to bind ATP and has no enzymatic activity." ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<P08192#SIP3397EC7FDDE0DB1B> rdf:type up:Annotation ;
  rdfs:comment "Mutant studies have shown that dihydrofolate synthase and folylpolyglutamate synthetase activities are catalyzed by a single catalytic site." .
<#_30E88C1A9454A519_rdfs.comment_47DE1BA5B3BBBCD2> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIP3397EC7FDDE0DB1B> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Mutant studies have shown that dihydrofolate synthase and folylpolyglutamate synthetase activities are catalyzed by a single catalytic site." ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> ,
    <P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> .
<P08192#SIP3E56E0AC1E840FD8> rdf:type up:Similarity_Annotation ;
  rdfs:comment "Belongs to the folylpolyglutamate synthase family." .
<#_FAD388F604E5524E_rdfs.comment_B258B463A244BB6F> rdf:type rdf:Statement ;
  rdf:subject <P08192#SIP3E56E0AC1E840FD8> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Belongs to the folylpolyglutamate synthase family." ;
  up:attribution <P08192#attribution-1F1D235CEE6E9F517881B603655DF439> .
annotation:PRO_0000168303 rdf:type up:Chain_Annotation ;
  rdfs:comment "Dihydrofolate synthase/folylpolyglutamate synthase" ;
  up:mass 45406 ;
  up:range range:22571016038986286tt1tt422 .
range:22571016038986286tt1tt422 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt1 ;
  faldo:end position:22571016038986286tt422 .
position:22571016038986286tt1 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 1 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt422 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 422 ;
  faldo:reference isoform:P08192-1 .
<P08192#SIP8DC07A685BD38775> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIP95AF3DE57F90D681> ;
  up:range range:22571016038986286tt29tt31 .
range:22571016038986286tt29tt31 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt29 ;
  faldo:end position:22571016038986286tt31 .
position:22571016038986286tt29 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 29 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt31 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 31 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_D9FC3D07EFD1CE5F> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP8DC07A685BD38775> ;
  up:attribution <P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> ,
    <P08192#attribution-84617662539E604414AE1ACED6285D43> .
<P08192#SIP90C1F3F4E171C6B2> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIP90C48BBBB9900709> ;
  up:range range:22571016038986286tt59tt62 .
range:22571016038986286tt59tt62 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt59 ;
  faldo:end position:22571016038986286tt62 .
position:22571016038986286tt59 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 59 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt62 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 62 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_9544FD50430B1B6F> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP90C1F3F4E171C6B2> ;
  up:attribution <P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> ,
    <P08192#attribution-84617662539E604414AE1ACED6285D43> ,
    <P08192#attribution-DA9F1973E8376DC8E537F671FCBD89DE> .
<P08192#SIP31AFDCD125071276> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIPB6BE8E1BB093DD52> ;
  up:range range:22571016038986286tt83tt83 .
range:22571016038986286tt83tt83 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt83 ;
  faldo:end position:22571016038986286tt83 .
position:22571016038986286tt83 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 83 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_949F4B612CB83FCA> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP31AFDCD125071276> ;
  up:attribution <P08192#attribution-432C5DEB00CD656D1C02890631411D3F> .
<P08192#SIP4B83BA8646BFCF3B> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIP95AF3DE57F90D681> ;
  up:range range:22571016038986286tt122tt125 .
range:22571016038986286tt122tt125 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt122 ;
  faldo:end position:22571016038986286tt125 .
position:22571016038986286tt122 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 122 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt125 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 125 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_B567DD0BA695688C> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP4B83BA8646BFCF3B> ;
  up:attribution <P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> ,
    <P08192#attribution-84617662539E604414AE1ACED6285D43> .
<P08192#SIP23319BD9D53BC76A> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIPB6BE8E1BB093DD52> ;
  up:range range:22571016038986286tt146tt146 .
range:22571016038986286tt146tt146 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt146 ;
  faldo:end position:22571016038986286tt146 .
position:22571016038986286tt146 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 146 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_265E3F5BAB813FFF> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP23319BD9D53BC76A> ;
  up:attribution <P08192#attribution-432C5DEB00CD656D1C02890631411D3F> .
<P08192#SIP4CD9420523469F2D> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIP95AF3DE57F90D681> ;
  up:range range:22571016038986286tt153tt155 .
range:22571016038986286tt153tt155 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt153 ;
  faldo:end position:22571016038986286tt155 .
position:22571016038986286tt153 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 153 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt155 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 155 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_2D493CF580AB4C8A> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP4CD9420523469F2D> ;
  up:attribution <P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> ,
    <P08192#attribution-84617662539E604414AE1ACED6285D43> .
<P08192#SIP97AF0FC22A4370BB> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIP4C0A1E9B08BA6529> ;
  up:range range:22571016038986286tt173tt173 .
range:22571016038986286tt173tt173 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt173 ;
  faldo:end position:22571016038986286tt173 .
position:22571016038986286tt173 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 173 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_40587B339852C365> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP97AF0FC22A4370BB> ;
  up:attribution <P08192#attribution-432C5DEB00CD656D1C02890631411D3F> .
<P08192#SIP47828FC49299BB64> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIP90C48BBBB9900709> ;
  up:range range:22571016038986286tt257tt257 .
range:22571016038986286tt257tt257 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt257 ;
  faldo:end position:22571016038986286tt257 .
position:22571016038986286tt257 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 257 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_7B1EE39B0A423ED4> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP47828FC49299BB64> ;
  up:attribution <P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> ,
    <P08192#attribution-84617662539E604414AE1ACED6285D43> ,
    <P08192#attribution-DA9F1973E8376DC8E537F671FCBD89DE> .
<P08192#SIP9455267EA92AF88A> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIP90C48BBBB9900709> ;
  up:range range:22571016038986286tt289tt289 .
range:22571016038986286tt289tt289 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt289 ;
  faldo:end position:22571016038986286tt289 .
position:22571016038986286tt289 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 289 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_21784D0577644AE8> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP9455267EA92AF88A> ;
  up:attribution <P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> ,
    <P08192#attribution-84617662539E604414AE1ACED6285D43> ,
    <P08192#attribution-DA9F1973E8376DC8E537F671FCBD89DE> .
<P08192#SIP56929EB990E94844> rdf:type up:Binding_Site_Annotation ;
  up:ligand <P08192#SIP90C48BBBB9900709> ;
  up:range range:22571016038986286tt302tt302 .
range:22571016038986286tt302tt302 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt302 ;
  faldo:end position:22571016038986286tt302 .
position:22571016038986286tt302 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 302 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_A2344C2BC1E85727> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP56929EB990E94844> ;
  up:attribution <P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> ,
    <P08192#attribution-84617662539E604414AE1ACED6285D43> ,
    <P08192#attribution-DA9F1973E8376DC8E537F671FCBD89DE> .
<P08192#SIP68151535FFDA3E75> rdf:type up:Modified_Residue_Annotation ;
  rdfs:comment "N6-carboxylysine" ;
  up:range range:22571016038986286tt188tt188 .
range:22571016038986286tt188tt188 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt188 ;
  faldo:end position:22571016038986286tt188 .
position:22571016038986286tt188 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 188 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_6BB472152A4FA464> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP68151535FFDA3E75> ;
  up:attribution <P08192#attribution-432C5DEB00CD656D1C02890631411D3F> .
<P08192#SIP10F271D3DEECB2A3> rdf:type up:Mutagenesis_Annotation ;
  rdfs:comment "Causes large decrease in affinity for both THF and DHP." ;
  up:substitution "H" ,
    "W" ;
  up:range range:22571016038986286tt122tt122 .
range:22571016038986286tt122tt122 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt122 ;
  faldo:end position:22571016038986286tt122 .
<#_kb.P08192_up.annotation_26FEB9A3534DE0AE> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP10F271D3DEECB2A3> ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<P08192#SIPA81F98E7269CCBD1> rdf:type up:Mutagenesis_Annotation ;
  rdfs:comment "Severely impairs activity with THF as substrate, even more so than with DHP. Both substrates show a reduced affinity, but the catalytic rate with THF is 23-fold lower than wild-type, whereas that with DHP is 2.5-fold lower. The catalytic rate with THF diglutamate is 10-fold higher than with monoglutamate and close to that of the wild-type enzyme." ;
  up:substitution "A" ;
  up:range range:22571016038986286tt154tt154 .
range:22571016038986286tt154tt154 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt154 ;
  faldo:end position:22571016038986286tt154 .
position:22571016038986286tt154 rdf:type faldo:Position ,
    faldo:ExactPosition ;
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  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_C84A124DEE243DCA> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPA81F98E7269CCBD1> ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<P08192#SIPC4942F905C350EAD> rdf:type up:Mutagenesis_Annotation ;
  rdfs:comment "Causes large decrease in affinity for both THF and DHP." ;
  up:substitution "H" ;
  up:range range:22571016038986286tt155tt155 .
range:22571016038986286tt155tt155 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt155 ;
  faldo:end position:22571016038986286tt155 .
<#_kb.P08192_up.annotation_A7D70BF458A55683> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPC4942F905C350EAD> ;
  up:attribution <P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> .
<P08192#SIPFA490F1CD4172CE3> rdf:type up:Sequence_Conflict_Annotation ;
  up:conflictingSequence <P08192#SIPF43A5C8B390B7260> ;
  up:substitution "M" ;
  up:range range:22571016038986286tt326tt326 .
range:22571016038986286tt326tt326 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt326 ;
  faldo:end position:22571016038986286tt326 .
position:22571016038986286tt326 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 326 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_52C534765AD1678C> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPFA490F1CD4172CE3> ;
  up:attribution <P08192#attribution-1F1D235CEE6E9F517881B603655DF439> .
<P08192#SIPFB54A12B35F458B9> rdf:type up:Sequence_Conflict_Annotation ;
  up:conflictingSequence <P08192#SIP5CB294F529382D22> ;
  up:substitution "M" ;
  up:range range:22571016038986286tt326tt326 .
<#_kb.P08192_up.annotation_8BAC6C608E1E454E> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPFB54A12B35F458B9> ;
  up:attribution <P08192#attribution-1F1D235CEE6E9F517881B603655DF439> .
<P08192#SIPE1FFA7045B82D29D> rdf:type up:Sequence_Conflict_Annotation ;
  up:conflictingSequence <P08192#SIP7700DE7EE0A86A22> ;
  up:substitution "AA" ;
  up:range range:22571016038986286tt328tt328 .
range:22571016038986286tt328tt328 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt328 ;
  faldo:end position:22571016038986286tt328 .
position:22571016038986286tt328 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 328 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_963FCC66FA23FD5A> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPE1FFA7045B82D29D> ;
  up:attribution <P08192#attribution-1F1D235CEE6E9F517881B603655DF439> .
<P08192#SIP58D4FEA5B556D89F> rdf:type up:Sequence_Conflict_Annotation ;
  up:conflictingSequence <P08192#SIP7700DE7EE0A86A22> ;
  up:substitution "EP" ;
  up:range range:22571016038986286tt391tt392 .
range:22571016038986286tt391tt392 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt391 ;
  faldo:end position:22571016038986286tt392 .
position:22571016038986286tt391 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 391 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt392 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 392 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_3BFC20F67889957C> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP58D4FEA5B556D89F> ;
  up:attribution <P08192#attribution-1F1D235CEE6E9F517881B603655DF439> .
<P08192#SIP7CA5FE7D914CA052> rdf:type up:Helix_Annotation ;
  up:range range:22571016038986286tt13tt20 .
range:22571016038986286tt13tt20 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt13 ;
  faldo:end position:22571016038986286tt20 .
position:22571016038986286tt13 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 13 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt20 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 20 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_6398572D95A141AF> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP7CA5FE7D914CA052> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIPE251A2E8429B8842> rdf:type up:Beta_Strand_Annotation ;
  up:range range:22571016038986286tt23tt27 .
range:22571016038986286tt23tt27 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt23 ;
  faldo:end position:22571016038986286tt27 .
position:22571016038986286tt23 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 23 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt27 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 27 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_A79B094773971486> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPE251A2E8429B8842> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIPE37A997B1606A20D> rdf:type up:Helix_Annotation ;
  up:range range:22571016038986286tt33tt42 .
range:22571016038986286tt33tt42 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt33 ;
  faldo:end position:22571016038986286tt42 .
position:22571016038986286tt33 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 33 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt42 rdf:type faldo:Position ,
    faldo:ExactPosition ;
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  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_A33EE28AF012473F> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPE37A997B1606A20D> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIPB04AFD2AC3D74B3E> rdf:type up:Beta_Strand_Annotation ;
  up:range range:22571016038986286tt48tt55 .
range:22571016038986286tt48tt55 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt48 ;
  faldo:end position:22571016038986286tt55 .
position:22571016038986286tt48 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 48 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt55 rdf:type faldo:Position ,
    faldo:ExactPosition ;
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  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_6751A88D426E9CC7> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPB04AFD2AC3D74B3E> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIP5E4223BA6E0D8D3F> rdf:type up:Helix_Annotation ;
  up:range range:22571016038986286tt60tt73 .
range:22571016038986286tt60tt73 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt60 ;
  faldo:end position:22571016038986286tt73 .
position:22571016038986286tt60 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 60 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt73 rdf:type faldo:Position ,
    faldo:ExactPosition ;
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  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_2C82A4F8E8509D01> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP5E4223BA6E0D8D3F> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
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  up:range range:22571016038986286tt78tt81 .
range:22571016038986286tt78tt81 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt78 ;
  faldo:end position:22571016038986286tt81 .
position:22571016038986286tt78 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 78 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt81 rdf:type faldo:Position ,
    faldo:ExactPosition ;
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  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_42A1BE9229812F0B> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP90603F387385A89C> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIP9E9471F2D26E3FB4> rdf:type up:Helix_Annotation ;
  up:range range:22571016038986286tt89tt92 .
range:22571016038986286tt89tt92 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt89 ;
  faldo:end position:22571016038986286tt92 .
position:22571016038986286tt89 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 89 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt92 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 92 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_A7CE528A3564164B> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP9E9471F2D26E3FB4> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIP1FB8B49DB98426BD> rdf:type up:Beta_Strand_Annotation ;
  up:range range:22571016038986286tt93tt95 .
range:22571016038986286tt93tt95 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt93 ;
  faldo:end position:22571016038986286tt95 .
position:22571016038986286tt93 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 93 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt95 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 95 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_13BF7DB44401E618> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP1FB8B49DB98426BD> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIPC7B0A7378E7C8BDF> rdf:type up:Helix_Annotation ;
  up:range range:22571016038986286tt102tt115 .
range:22571016038986286tt102tt115 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt102 ;
  faldo:end position:22571016038986286tt115 .
position:22571016038986286tt102 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 102 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt115 rdf:type faldo:Position ,
    faldo:ExactPosition ;
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  faldo:reference isoform:P08192-1 .
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  up:range range:22571016038986286tt350tt354 .
range:22571016038986286tt350tt354 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt350 ;
  faldo:end position:22571016038986286tt354 .
position:22571016038986286tt350 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 350 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt354 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 354 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_406C3B7D9B9E58F6> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP9A5281FE3280890A> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIP2CC4D2BEA669D3C5> rdf:type up:Beta_Strand_Annotation ;
  up:range range:22571016038986286tt359tt362 .
range:22571016038986286tt359tt362 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt359 ;
  faldo:end position:22571016038986286tt362 .
position:22571016038986286tt359 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 359 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt362 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 362 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_6895284D3258F314> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP2CC4D2BEA669D3C5> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIPA9BE29C419526003> rdf:type up:Helix_Annotation ;
  up:range range:22571016038986286tt365tt372 .
range:22571016038986286tt365tt372 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt365 ;
  faldo:end position:22571016038986286tt372 .
position:22571016038986286tt365 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 365 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt372 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 372 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_90C6868FBB4BD98D> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPA9BE29C419526003> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIPA7F916A5AC46172D> rdf:type up:Helix_Annotation ;
  up:range range:22571016038986286tt381tt391 .
range:22571016038986286tt381tt391 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt381 ;
  faldo:end position:22571016038986286tt391 .
position:22571016038986286tt381 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 381 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_D36E381BCD5EB122> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIPA7F916A5AC46172D> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIP1FA58EC06BDF4FCF> rdf:type up:Beta_Strand_Annotation ;
  up:range range:22571016038986286tt397tt403 .
range:22571016038986286tt397tt403 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt397 ;
  faldo:end position:22571016038986286tt403 .
position:22571016038986286tt397 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 397 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt403 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 403 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_4AEA66D68A10FE12> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP1FA58EC06BDF4FCF> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIP34BF60E3FFA81E8B> rdf:type up:Helix_Annotation ;
  up:range range:22571016038986286tt404tt417 .
range:22571016038986286tt404tt417 rdf:type faldo:Region ;
  faldo:begin position:22571016038986286tt404 ;
  faldo:end position:22571016038986286tt417 .
position:22571016038986286tt404 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 404 ;
  faldo:reference isoform:P08192-1 .
position:22571016038986286tt417 rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 417 ;
  faldo:reference isoform:P08192-1 .
<#_kb.P08192_up.annotation_3C55D2DF9EDB44EA> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:annotation ;
  rdf:object <P08192#SIP34BF60E3FFA81E8B> ;
  up:attribution <P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> .
<P08192#SIP95AF3DE57F90D681> rdfs:subClassOf <http://purl.obolibrary.org/obo/CHEBI_17839> .
<P08192#SIP90C48BBBB9900709> rdfs:subClassOf <http://purl.obolibrary.org/obo/CHEBI_30616> .
<P08192#SIPB6BE8E1BB093DD52> rdfs:subClassOf <http://purl.obolibrary.org/obo/CHEBI_18420> ;
  rdfs:label "1" .
<P08192#SIP4C0A1E9B08BA6529> rdfs:subClassOf <http://purl.obolibrary.org/obo/CHEBI_18420> ;
  rdfs:label "2" .
<#_kb.P08192_up.classifiedWith_obo.GO_0005737> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0005737 ;
  up:attribution <P08192#attribution-64F920643AF952E2DC410BAF9E816C1B> .
<#_kb.P08192_up.classifiedWith_obo.GO_0005524> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0005524 ;
  up:attribution <P08192#attribution-A969DEE2FB45E2286857B21AD327A51B> .
<#_kb.P08192_up.classifiedWith_obo.GO_0008841> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0008841 ;
  up:attribution <P08192#attribution-64F920643AF952E2DC410BAF9E816C1B> .
<#_kb.P08192_up.classifiedWith_obo.GO_0097216> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0097216 ;
  up:attribution <P08192#attribution-64F920643AF952E2DC410BAF9E816C1B> .
<#_kb.P08192_up.classifiedWith_obo.GO_0046872> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0046872 ;
  up:attribution <P08192#attribution-A969DEE2FB45E2286857B21AD327A51B> .
<#_kb.P08192_up.classifiedWith_obo.GO_0004326> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0004326 ;
  up:attribution <P08192#attribution-64F920643AF952E2DC410BAF9E816C1B> .
<#_kb.P08192_up.classifiedWith_obo.GO_0046656> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0046656 ;
  up:attribution <P08192#attribution-A969DEE2FB45E2286857B21AD327A51B> .
<#_kb.P08192_up.classifiedWith_obo.GO_0009396> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0009396 ;
  up:attribution <P08192#attribution-B1173712290FD2B95AA2CFBCD6874F84> .
<#_kb.P08192_up.classifiedWith_obo.GO_0006730> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0006730 ;
  up:attribution <P08192#attribution-A969DEE2FB45E2286857B21AD327A51B> .
<#_kb.P08192_up.classifiedWith_obo.GO_0046654> rdf:type rdf:Statement ;
  rdf:subject <P08192> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0046654 ;
  up:attribution <P08192#attribution-29E984218F13346DF40D40BA4D897447> .
isoform:P08192-1 rdf:type up:Simple_Sequence ;
  up:modified "1997-11-01"^^xsd:date ;
  up:version 2 ;
  up:mass 45406 ;
  up:md5Checksum "280c609c885bd4731710722942144c15" ;
  rdf:value "MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSGGK" .
<P08192#attribution-64F920643AF952E2DC410BAF9E816C1B> dcterms:creator <http://purl.uniprot.org/goa-projects/EcoCyc> ;
  up:manual true ;
  up:evidence ECO:0000314 .
<P08192#attribution-A969DEE2FB45E2286857B21AD327A51B> dcterms:creator <http://purl.uniprot.org/goa-projects/UniProtKB-KW> ;
  up:evidence ECO:0007669 .
<P08192#attribution-B1173712290FD2B95AA2CFBCD6874F84> dcterms:creator <http://purl.uniprot.org/goa-projects/GO_Central> ;
  up:manual true ;
  up:evidence ECO:0000318 .
<P08192#attribution-29E984218F13346DF40D40BA4D897447> dcterms:creator <http://purl.uniprot.org/goa-projects/UniProtKB-UniPathway> ;
  up:evidence ECO:0007669 .
<P08192#attribution-432C5DEB00CD656D1C02890631411D3F> up:manual true ;
  up:evidence ECO:0000269 ;
  up:source citation:15705579 .
<P08192#attribution-CF5719D6C2E5BD17BB09A275AF357FF4> up:manual true ;
  up:evidence ECO:0000269 ;
  up:source citation:18232714 .
<P08192#attribution-796FF6227A6A1CC4FA1B4DA17C090715> up:manual true ;
  up:evidence ECO:0000269 ;
  up:source citation:1989505 .
<P08192#attribution-59DCD7B57AB43F63AE9D02833EBA6E76> up:manual true ;
  up:evidence ECO:0000269 ;
  up:source citation:2985605 .
<P08192#attribution-9BC0120C333C19F05CE9E4AF97C0D195> up:manual true ;
  up:evidence ECO:0000303 ;
  up:source citation:15705579 .
<P08192#attribution-8C8386F3D9594C3D0E861B04840C65BB> up:manual true ;
  up:evidence ECO:0000303 ;
  up:source citation:18232714 .
<P08192#attribution-8E6EF8B15131E5BDEF64DDB5C3F9F811> up:manual true ;
  up:evidence ECO:0000303 ;
  up:source citation:2985605 .
<P08192#attribution-1F1D235CEE6E9F517881B603655DF439> up:manual true ;
  up:evidence ECO:0000305 .
<P08192#attribution-B9ACC0F7F905453D99D8B77CA01FC74D> up:manual true ;
  up:evidence ECO:0000305 ;
  up:source citation:15705579 .
<P08192#attribution-DF5229331033C3EE791E216E7A28B8B2> up:manual true ;
  up:evidence ECO:0000305 ;
  up:source citation:2985605 .
<P08192#attribution-84617662539E604414AE1ACED6285D43> up:manual true ;
  up:evidence ECO:0007744 ;
  up:source <http://rdf.wwpdb.org/pdb/1W78> .
<P08192#attribution-DA9F1973E8376DC8E537F671FCBD89DE> up:manual true ;
  up:evidence ECO:0007744 ;
  up:source <http://rdf.wwpdb.org/pdb/1W7K> .
<P08192#attribution-5DF72C0655444E66E526D6851AD4F70E> up:evidence ECO:0007829 ;
  up:source <http://rdf.wwpdb.org/pdb/1W78> .