Gene

pik3cb

ID

ZDB-GENE-030131-1904

Name

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

Symbol

pik3cb Nomenclature History

Previous Names

fb92a07
wu:fb92a07

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in cell migration; phosphatidylinositol 3-kinase signaling; and phosphatidylinositol metabolic process. Predicted to localize to cytoplasm; phosphatidylinositol 3-kinase complex; and plasma membrane. Human ortholog(s) of this gene implicated in glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pik3cb Human Ortholog

No data available

Associated With pik3cb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
Domain	IPR002420	C2 phosphatidylinositol 3-kinase-type domain
Domain	IPR003113	Phosphatidylinositol 3-kinase, adaptor-binding domain
Family	IPR015433	Phosphatidylinositol kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	C2 domain superfamily	C2 phosphatidylinositol 3-kinase-type domain	Phosphatidylinositol 3-/4-kinase, catalytic domain	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Phosphatidylinositol 3/4-kinase, conserved site	Phosphatidylinositol 3-kinase, adaptor-binding domain	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Phosphatidylinositol kinase	Phosphoinositide 3-kinase, accessory (PIK) domain	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Protein kinase-like domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:E7F251 InterPro	1080

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pik3cb-202 (1) Ensembl	Havana	5316 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations