CHEBI:145421 - rigosertib sodium

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ChEBI Name rigosertib sodium
ChEBI ID CHEBI:145421
Definition The sodium salt of rigosertib. It is an anti-cancer agent which has been granted Orphan Drug Designation by the FDA for use in patients with myelodysplastic syndromes (MDS).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB4752040, eMolecules:3715751, Selleckchem:cefoperazone-cefobid, ZINC000003830432
Download Molfile XML SDF
Formula C21H24NO8S.Na
Net Charge 0
Average Mass 473.470
Monoisotopic Mass 473.11203
InChI InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
InChIKey VLQLUZFVFXYXQE-USRGLUTNSA-M
SMILES C1(=CC(=C(C(=C1)OC)/C=C/S(CC2=CC=C(C(=C2)NCC([O-])=O)OC)(=O)=O)OC)OC.[Na+]
Roles Classification
Biological Role(s): microtubule-destabilising agent
Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
EC 2.7.11.21 (polo kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of any polo kinase (EC 2.7.11.21).
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing rigosertib sodium (CHEBI:145421) has part rigosertib(1−) (CHEBI:145422)
rigosertib sodium (CHEBI:145421) has role antineoplastic agent (CHEBI:35610)
rigosertib sodium (CHEBI:145421) has role apoptosis inducer (CHEBI:68495)
rigosertib sodium (CHEBI:145421) has role EC 2.7.11.21 (polo kinase) inhibitor (CHEBI:145425)
rigosertib sodium (CHEBI:145421) has role microtubule-destabilising agent (CHEBI:61951)
rigosertib sodium (CHEBI:145421) is a organic sodium salt (CHEBI:38700)
IUPAC Name
sodium [2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)anilino]acetate
Synonyms Sources
(E)-ON 01910.Na ChEBI
novonex ChemIDplus
ON 01910 sodium ChEBI
ON 01910 sodium salt ChemIDplus
ON 01910.Na ChemIDplus
ON-01910 sodium ChEBI
ON-01910 sodium salt ChEBI
ON-01910.Na ChEBI
rigosertib sodium salt ChEBI
Brand Name Source
Estybon ChEBI
Manual Xrefs Databases
D10155 KEGG DRUG
DBSALT002144 DrugBank
View more database links
Registry Number Type Source
592542-60-4 CAS Registry Number ChemIDplus
Citations Types Sources
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Last Modified
19 November 2019