Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas.
It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as Glibenclamide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in older people.
It was discovered in 1956. |
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Homo sapiens
(NCBI:txid9606)
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See:
DOI
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human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
insulin secretagogue
A secretagogue that causes the secretion of insulin.
potassium channel blocker
An agent that inhibits cell membrane glycoproteins that are selectively permeable to potassium ions.
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hypoglycemic agent
A drug which lowers the blood glucose level.
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View more via ChEBI Ontology
N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide
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tolbutamida
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ChemIDplus
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tolbutamide
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ChemIDplus
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tolbutamidum
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ChemIDplus
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1-Butyl-3-(p-methylphenylsulfonyl)urea
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ChemIDplus
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1-Butyl-3-(p-tolylsulfonyl)urea
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ChemIDplus
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1-Butyl-3-tosylurea
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ChemIDplus
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1-p-Toluenesulfonyl-3-butylurea
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ChemIDplus
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3-(p-Tolyl-4-sulfonyl)-1-butylurea
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ChemIDplus
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N-(4-Methylbenzenesulfonyl)-N'-butylurea
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ChemIDplus
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N-(4-Methylphenylsulfonyl)-N'-butylurea
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ChemIDplus
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N-(p-Methylbenzenesulfonyl)-N'-butylurea
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NIST Chemistry WebBook
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N-(Sulfonyl-p-methylbenzene)-N'-N-butylurea
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NIST Chemistry WebBook
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N-Butyl-N'-(4-methylphenylsulfonyl)urea
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ChemIDplus
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N-Butyl-N'-(p-tolylsulfonyl)urea
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ChemIDplus
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N-Butyl-N'-p-toluenesulfonylurea
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ChemIDplus
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N-n-Butyl-N'-tosylurea
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ChemIDplus
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Orinase (TN)
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KEGG DRUG
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Tolbutamide
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KEGG COMPOUND
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Tolylsulfonylbutylurea
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NIST Chemistry WebBook
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1984428
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Reaxys Registry Number
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Reaxys
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64-77-7
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CAS Registry Number
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KEGG COMPOUND
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64-77-7
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CAS Registry Number
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NIST Chemistry WebBook
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64-77-7
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CAS Registry Number
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ChemIDplus
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