CHEBI:3387 - carbamazepine

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ChEBI Name carbamazepine
ChEBI ID CHEBI:3387
Definition A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:115086
Supplier Information ChemicalBook:CB1143564, eMolecules:27677745, eMolecules:535714, Selleckchem:Carbamazepine(Carbatrol), ZINC000000004785
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Formula C15H12N2O
Net Charge 0
Average Mass 236.26860
Monoisotopic Mass 236.09496
InChI InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
InChIKey FFGPTBGBLSHEPO-UHFFFAOYSA-N
SMILES NC(=O)N1c2ccccc2C=Cc2ccccc12
Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Biological Role(s): drug allergen
Any drug which causes the onset of an allergic reaction.
sodium channel blocker
An agent that inhibits sodium influx through cell membranes.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
mitogen
A chemical substance that encourages a cell to commence cell division, triggering mitosis.
glutamate transporter activator
A neurotransmitter transporter modulator that activates glutamate transporters.
Application(s): drug allergen
Any drug which causes the onset of an allergic reaction.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
analgesic
An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
antimanic drug
Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders.
anticonvulsant
A drug used to prevent seizures or reduce their severity.
glutamate transporter activator
A neurotransmitter transporter modulator that activates glutamate transporters.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing carbamazepine (CHEBI:3387) has role analgesic (CHEBI:35480)
carbamazepine (CHEBI:3387) has role anticonvulsant (CHEBI:35623)
carbamazepine (CHEBI:3387) has role antimanic drug (CHEBI:35477)
carbamazepine (CHEBI:3387) has role drug allergen (CHEBI:88188)
carbamazepine (CHEBI:3387) has role EC 3.5.1.98 (histone deacetylase) inhibitor (CHEBI:61115)
carbamazepine (CHEBI:3387) has role environmental contaminant (CHEBI:78298)
carbamazepine (CHEBI:3387) has role glutamate transporter activator (CHEBI:64370)
carbamazepine (CHEBI:3387) has role mitogen (CHEBI:52290)
carbamazepine (CHEBI:3387) has role non-narcotic analgesic (CHEBI:35481)
carbamazepine (CHEBI:3387) has role sodium channel blocker (CHEBI:38633)
carbamazepine (CHEBI:3387) has role xenobiotic (CHEBI:35703)
carbamazepine (CHEBI:3387) is a dibenzoazepine (CHEBI:47804)
carbamazepine (CHEBI:3387) is a ureas (CHEBI:47857)
Incoming carbamazepine-10,11-epoxide (CHEBI:3388) has functional parent carbamazepine (CHEBI:3387)
licarbazepine (CHEBI:701) has functional parent carbamazepine (CHEBI:3387)
IUPAC Name
5H-dibenzo[b,f]azepine-5-carboxamide
INNs Sources
carbamazepina ChemIDplus
carbamazepine ChemIDplus
carbamazepinum ChemIDplus
Synonyms Sources
5-Carbamoyl-5H-dibenz(b,f)azepine ChemIDplus
5-carbamoyl-5H-dibenz[b,f]azepine NIST Chemistry WebBook
5-Carbamoyl-5H-dibenzo(b,f)azepine ChemIDplus
5-Carbamyl-5H-dibenzo(b,f)azepine ChemIDplus
5H-Dibenz(b,f)azepine-5-carboxamide ChemIDplus
Carbamazepen ChemIDplus
Brand Name Source
Carnexiv ChemIDplus
Manual Xrefs Databases
489 DrugCentral
C06868 KEGG COMPOUND
Carbamazepine Wikipedia
D00252 KEGG DRUG
DB00564 DrugBank
HMDB0014704 HMDB
LSM-3610 LINCS
US2004220187 Patent
US2007167446 Patent
US2011177136 Patent
US2011245283 Patent
US2948718 Patent
View more database links
Registry Numbers Types Sources
1246090 Reaxys Registry Number Reaxys
298-46-4 CAS Registry Number NIST Chemistry WebBook
298-46-4 CAS Registry Number ChemIDplus
Citations Waiting for Citations
Last Modified
09 February 2018
General Comment
2014-10-29 Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag