Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas.
It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as Glibenclamide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in older people.
It was discovered in 1956. |
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InChI=1S/CHCl3/c2-1(3)4/h1H |
HEDRZPFGACZZDS-UHFFFAOYSA-N |
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non-polar solvent
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carcinogenic agent
A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
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refrigerant
A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.
central nervous system drug
A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
non-polar solvent
inhalation anaesthetic
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View more via ChEBI Ontology
1,1,1-trichloromethane
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ChemIDplus
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CHCl3
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IUPAC
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Chloroform
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KEGG COMPOUND
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chloroforme
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ChemIDplus
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chloroformium pro narcosi
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ChEBI
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Trichlormethan
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NIST Chemistry WebBook
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trichloromethane
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NIST Chemistry WebBook
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trichlorométhane
|
ChEBI
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4363
|
DrugCentral
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c0595
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UM-BBD
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C13827
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KEGG COMPOUND
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Chloroform
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Wikipedia
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CPD-843
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MetaCyc
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HMDB0029596
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HMDB
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LSM-37229
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LINCS
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MCH
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PDBeChem
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View more database links |
1731042
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Reaxys Registry Number
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Reaxys
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1837
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Gmelin Registry Number
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Gmelin
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67-66-3
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CAS Registry Number
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NIST Chemistry WebBook
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67-66-3
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CAS Registry Number
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ChemIDplus
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