CHEBI:3750 - clofibrate

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ChEBI Name clofibrate
ChEBI ID CHEBI:3750
Definition The ethyl ester of clofibric acid.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB1384824, eMolecules:502037, ZINC000001600920
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β-Endorphin (beta-endorphin) is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central nervous system and peripheral nervous system. It is one of three endorphins that are produced in humans, the others being α-endorphin and γ-endorphin. There are multiple forms of β-endorphins with the full sequence of Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu (31 amino acids) denoted as β-endorphin(1-31) and variants truncated to the first 26 and 27 amino acids as β-endorphin(1-26) and β-endorphin(1-27). However, β-endorphin(1-31) is the only form that possess a potent analgesic effect and it is the primary form located in the anterior pituitary gland, and regions such as the hypothalamus, midbrain, and amygdala. The first 16 amino acids are identical to α-endorphin. β-Endorphin is considered to be a part of the endogenous opioid and endorphin classes of neuropeptides; all of the established endogenous opioid peptides contain the same N-terminal amino acid sequence, Tyr-Gly-Gly-Phe, followed by either -Met or -Leu. Function of β-endorphin has been known to be associated with hunger, thrill, pain, maternal care, sexual behavior, and reward cognition. In the broadest sense, β-endorphin is primarily utilized in the body to reduce stress and maintain homeostasis. In behavioral research, studies have shown that β-endorphin is released via volume transmission into the ventricular system in response to a variety of stimuli, and novel stimuli in particular.
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Formula C12H15ClO3
Net Charge 0
Average Mass 242.69900
Monoisotopic Mass 242.07097
InChI InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChIKey KNHUKKLJHYUCFP-UHFFFAOYSA-N
SMILES CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
Roles Classification
Biological Role(s): PPARalpha agonist
A PPAR modulator which activates the peroxisome proliferator-activated receptor-alpha.
Application(s): anticholesteremic drug
A substance used to lower plasma cholesterol levels.
antilipemic drug
A substance used to treat hyperlipidemia (an excess of lipids in the blood).
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
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ChEBI Ontology
Outgoing clofibrate (CHEBI:3750) has functional parent clofibric acid (CHEBI:34648)
clofibrate (CHEBI:3750) has role anticholesteremic drug (CHEBI:35821)
clofibrate (CHEBI:3750) has role antilipemic drug (CHEBI:35679)
clofibrate (CHEBI:3750) has role geroprotector (CHEBI:176497)
clofibrate (CHEBI:3750) has role PPARα agonist (CHEBI:70782)
clofibrate (CHEBI:3750) is a aromatic ether (CHEBI:35618)
clofibrate (CHEBI:3750) is a ethyl ester (CHEBI:23990)
clofibrate (CHEBI:3750) is a monochlorobenzenes (CHEBI:83403)
IUPAC Name
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
INNs Sources
clofibrate ChemIDplus
clofibrato ChemIDplus
clofibratum ChemIDplus
Synonyms Sources
2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester ChemIDplus
2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester ChemIDplus
alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester ChemIDplus
alpha-p-Chlorophenoxyisobutyryl ethyl ester ChemIDplus
Clofibrate KEGG COMPOUND
EPIB DrugBank
Ethyl 2-(p-chlorophenoxy)isobutyrate ChemIDplus
Ethyl chlorophenoxyisobutyrate ChemIDplus
Ethyl clofibrate ChemIDplus
Liprin ChemIDplus
Brand Names Sources
Atromid-S KEGG DRUG
ELPI DrugBank
Lipofacton DrugBank
Manual Xrefs Databases
2694 ChemSpider
694 DrugCentral
C06916 KEGG COMPOUND
Clofibrate Wikipedia
D00279 KEGG DRUG
DB00636 DrugBank
GB860303 Patent
HMDB0014774 HMDB
LSM-2996 LINCS
US3262850 Patent
View more database links
Registry Numbers Types Sources
1913459 Beilstein Registry Number Beilstein
637-07-0 CAS Registry Number ChemIDplus
637-07-0 CAS Registry Number NIST Chemistry WebBook
Citations Types Sources
23603800 PubMed citation Europe PMC
26949064 PubMed citation Europe PMC
27354598 PubMed citation Europe PMC
28248971 PubMed citation Europe PMC
28485676 PubMed citation Europe PMC
28512725 PubMed citation Europe PMC
28779283 PubMed citation Europe PMC
29059162 PubMed citation Europe PMC
30642049 PubMed citation Europe PMC
33070841 PubMed citation Europe PMC
33893992 PubMed citation Europe PMC
PMC7258001 PubMed Central citation Europe PMC
PMC8265473 PubMed Central citation Europe PMC
Last Modified
20 September 2021