CHEBI:3763 - clorgyline

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ChEBI Name clorgyline
ChEBI ID CHEBI:3763
Definition An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information ChemicalBook:CB9733804, eMolecules:535136, Selleckchem:bay-11-7082-bay-11-7821, ZINC000002568458
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Amoxicillin is an antibiotic medication belonging to the aminopenicillin class of the penicillin family. The drug is used to treat bacterial infections such as middle ear infection, strep throat, pneumonia, skin infections, odontogenic infections, and urinary tract infections. It is taken orally (swallowed by mouth), or less commonly by either intramuscular injection or by an IV bolus injection, which is a relatively quick intravenous injection lasting from a couple of seconds to a few minutes. Common adverse effects include nausea and rash. It may also increase the risk of yeast infections and, when used in combination with clavulanic acid, diarrhea. It should not be used in those who are allergic to penicillin. While usable in those with kidney problems, the dose may need to be decreased. Its use in pregnancy and breastfeeding does not appear to be harmful. Amoxicillin is in the β-lactam family of antibiotics. Amoxicillin was discovered in 1958 and came into medical use in 1972. Amoxil was approved for medical use in the United States in 1974, and in the United Kingdom in 1977. It is on the World Health Organization's List of Essential Medicines. It is one of the most commonly prescribed antibiotics in children. Amoxicillin is available as a generic medication. In 2022, it was the 26th most commonly prescribed medication in the United States, with more than 20 million prescriptions.
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Formula C13H15Cl2NO
Net Charge 0
Average Mass 272.17000
Monoisotopic Mass 271.05307
InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
InChIKey BTFHLQRNAMSNLC-UHFFFAOYSA-N
SMILES CN(CCCOc1ccc(Cl)cc1Cl)CC#C
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 1.4.3.4 (monoamine oxidase) inhibitor
An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4).
Application(s): antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing clorgyline (CHEBI:3763) has role antidepressant (CHEBI:35469)
clorgyline (CHEBI:3763) has role EC 1.4.3.4 (monoamine oxidase) inhibitor (CHEBI:38623)
clorgyline (CHEBI:3763) is a aromatic ether (CHEBI:35618)
clorgyline (CHEBI:3763) is a dichlorobenzene (CHEBI:23697)
clorgyline (CHEBI:3763) is a terminal acetylenic compound (CHEBI:73477)
clorgyline (CHEBI:3763) is a tertiary amino compound (CHEBI:50996)
IUPAC Name
N-[3-(2,4-dichlorophenoxy)propyl]-N-methylprop-2-yn-1-amine
INNs Sources
clorgilina ChemIDplus
clorgiline ChemIDplus
clorgiline WHO MedNet
clorgilinum ChemIDplus
Synonyms Sources
M & B 9302 ChemIDplus
M and B 9302 ChemIDplus
M&B 9302 ChemIDplus
N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl-2-propynylamine ChemIDplus
N-methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine ChEBI
Manual Xrefs Databases
C11685 KEGG COMPOUND
Clorgiline Wikipedia
CPD-7656 MetaCyc
D03248 KEGG DRUG
DB04017 DrugBank
LSM-5808 LINCS
MLG PDBeChem
View more database links
Registry Numbers Types Sources
17780-72-2 CAS Registry Number ChemIDplus
17780-72-2 CAS Registry Number NIST Chemistry WebBook
1976758 Reaxys Registry Number Reaxys
Citations Waiting for Citations
Last Modified
25 February 2016