CHEBI:44915 - propofol

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ChEBI Name propofol
ChEBI ID CHEBI:44915
Definition A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:44914, CHEBI:8495
Supplier Information ChemicalBook:CB4101882, eMolecules:536859, ZINC000000968303
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Formula C12H18O
Net Charge 0
Average Mass 178.27072
Monoisotopic Mass 178.13577
InChI InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
InChIKey OLBCVFGFOZPWHH-UHFFFAOYSA-N
SMILES CC(C)c1cccc(C(C)C)c1O
Roles Classification
Chemical Role(s): radical scavenger
A role played by a substance that can react readily with, and thereby eliminate, radicals.
Application(s): intravenous anaesthetic

sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
anticonvulsant
A drug used to prevent seizures or reduce their severity.
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ChEBI Ontology
Outgoing propofol (CHEBI:44915) has role anticonvulsant (CHEBI:35623)
propofol (CHEBI:44915) has role antiemetic (CHEBI:50919)
propofol (CHEBI:44915) has role intravenous anaesthetic (CHEBI:38877)
propofol (CHEBI:44915) has role radical scavenger (CHEBI:48578)
propofol (CHEBI:44915) has role sedative (CHEBI:35717)
propofol (CHEBI:44915) is a phenols (CHEBI:33853)
Incoming 4-hydroxypropofol (CHEBI:145211) has functional parent propofol (CHEBI:44915)
IUPAC Name
2,6-bis(propan-2-yl)phenol
INN Source
propofol KEGG DRUG
Synonyms Sources
2,6-bis(1-methylethyl)phenol ChemIDplus
2,6-BIS(1-METHYLETHYL)PHENOL PDBeChem
2,6-Diisopropylphenol KEGG COMPOUND
Disoprofol ChemIDplus
Propofol KEGG COMPOUND
propofolum ChemIDplus
Brand Names Sources
Diprivan KEGG DRUG
Disoprivan DrugBank
Disoprofol DrugBank
Rapinovet DrugBank
Manual Xrefs Databases
1846 VSDB
2302 DrugCentral
C07523 KEGG COMPOUND
D00549 KEGG DRUG
DB00818 DrugBank
LSM-3847 LINCS
PFL PDBeChem
Propofol Wikipedia
View more database links
Registry Numbers Types Sources
1866484 Beilstein Registry Number ChemIDplus
2078-54-8 CAS Registry Number ChemIDplus
2078-54-8 CAS Registry Number NIST Chemistry WebBook
Last Modified
07 November 2019
General Comment
2011-01-05 Propofol is a short-acting anaesthetic, administered intravenously for the induction and maintenance of general anaesthesia. It is also used for sedation in adults undergoing diagnostic procedures, or undergoing surgery in conjunction with local or regional anaesthesia. It has no analgesic activity.