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Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It can be taken orally (swallowed by mouth), inserted rectally as a suppository, injected intramuscularly, injected intravenously, applied to the skin topically, or through eye drops. Improvements in pain last up to eight hours. It is also available as the fixed-dose combination diclofenac/misoprostol (Arthrotec) to help protect the stomach.
Common side effects include abdominal pain, gastrointestinal bleeding, nausea, dizziness, headache, and swelling. Serious side effects may include heart disease, stroke, kidney problems, and stomach ulceration. Use is not recommended in the third trimester of pregnancy. It is likely safe during breastfeeding. Diclofenac is believed to work by decreasing the production of prostaglandins, like other drugs in this class.
In 2022, it was the 51st most commonly prescribed medication in the United States, with more than 12 million prescriptions. It is available as its acid or in two salts, as either diclofenac sodium or potassium. |
Read full article at Wikipedia
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environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
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non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
drug allergen
Any drug which causes the onset of an allergic reaction.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
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non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
drug allergen
Any drug which causes the onset of an allergic reaction.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
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View more via ChEBI Ontology
2-[(2,6-dichlorophenyl)amino]benzeneacetic acid
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{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
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diclofenac
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ChemIDplus
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diclofenaco
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ChemIDplus
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diclofenacum
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ChemIDplus
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2-((2,6-dichlorophenyl)amino)benzeneacetic acid
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ChemIDplus
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[2-(2,6-dichloroanilino)phenyl]acetic acid
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NIST Chemistry WebBook
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Diclofenac
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KEGG COMPOUND
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diclofenac acid
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ChemIDplus
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diclofenamic acid
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DrugCentral
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1933
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VSDB
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865
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DrugCentral
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C01690
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KEGG COMPOUND
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D07816
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KEGG DRUG
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DB00586
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DrugBank
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Diclofenac
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Wikipedia
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DIF
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PDBeChem
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HMDB0014724
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HMDB
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LSM-2160
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LINCS
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NL6604752
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Patent
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US3558690
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Patent
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View more database links |
15307-86-5
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CAS Registry Number
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KEGG COMPOUND
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15307-86-5
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CAS Registry Number
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ChemIDplus
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15307-86-5
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CAS Registry Number
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NIST Chemistry WebBook
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2146636
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Reaxys Registry Number
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Reaxys
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