fluphenazine (CHEBI:5123)

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ChEBI Name	fluphenazine

ChEBI ID	CHEBI:5123

Definition	A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information	eMolecules:6882610, ZINC000001730666

Download	Molfile XML SDF

Wikipedia	License
Lanthionine is a nonproteinogenic amino acid with the chemical formula (HOOC-CH(NH2)-CH2-S-CH2-CH(NH2)-COOH). It is typically formed by a cysteine residue and a dehydrated serine residue. Despite its name, lanthionine does not contain the element lanthanum.
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Formula

C22H26F3N3OS

Net Charge

Average Mass

437.52200

Monoisotopic Mass

437.17487

InChI

InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2

InChIKey

PLDUPXSUYLZYBN-UHFFFAOYSA-N

SMILES

OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.

Application(s):	phenothiazine antipsychotic drug dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.

ChEBI Ontology
Outgoing	fluphenazine (CHEBI:5123) has parent hydride 10H-phenothiazine (CHEBI:37931) fluphenazine (CHEBI:5123) has role anticoronaviral agent (CHEBI:149553) fluphenazine (CHEBI:5123) has role dopaminergic antagonist (CHEBI:48561) fluphenazine (CHEBI:5123) has role phenothiazine antipsychotic drug (CHEBI:37930) fluphenazine (CHEBI:5123) is a N-alkylpiperazine (CHEBI:46845) fluphenazine (CHEBI:5123) is a organofluorine compound (CHEBI:37143) fluphenazine (CHEBI:5123) is a phenothiazines (CHEBI:38093)

Incoming	fluphenazine decanoate (CHEBI:5124) has functional parent fluphenazine (CHEBI:5123)

IUPAC Name

2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol

Synonyms	Sources
1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine	ChemIDplus
10-(3'-(4''-(β-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine	ChemIDplus
10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine	NIST Chemistry WebBook
2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol	NIST Chemistry WebBook
2-(trifluoromethyl)-10-(3-(1-(β-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine	ChemIDplus
4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol	ChemIDplus
4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol	ChemIDplus
4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol	ChemIDplus
flufenazina	ChemIDplus
Fluorfenazine	DrugBank
Fluorophenazine	DrugBank
Fluorphenazine	DrugBank
Fluphenazine	KEGG COMPOUND
Triflumethazine	DrugBank

Last Modified

23 April 2020