lenalidomide (CHEBI:63791)

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ChEBI Name	lenalidomide

ChEBI ID	CHEBI:63791

Definition	A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-α.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Anonymous

Supplier Information	ChemicalBook:CB5159244, eMolecules:474218

Download	Molfile XML SDF

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Formula

C13H13N3O3

Net Charge

Average Mass

259.26060

Monoisotopic Mass

259.09569

InChI

InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

InChIKey

GOTYRUGSSMKFNF-UHFFFAOYSA-N

SMILES

Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system.

Application(s):	angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system.

ChEBI Ontology
Outgoing	lenalidomide (CHEBI:63791) has role angiogenesis inhibitor (CHEBI:48422) lenalidomide (CHEBI:63791) has role antineoplastic agent (CHEBI:35610) lenalidomide (CHEBI:63791) has role immunomodulator (CHEBI:50846) lenalidomide (CHEBI:63791) is a aromatic amine (CHEBI:33860) lenalidomide (CHEBI:63791) is a dicarboximide (CHEBI:35356) lenalidomide (CHEBI:63791) is a isoindoles (CHEBI:24897) lenalidomide (CHEBI:63791) is a piperidones (CHEBI:48589)

IUPAC Name

3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

INN	Source
lenalidomide	KEGG DRUG

Synonyms	Sources
1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline	ChEBI
3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione	ChemIDplus

Brand Name	Source
Revlimid	KEGG DRUG

Last Modified

22 February 2017