| Mannitol is a type of sugar alcohol used as a sweetener and medication. It is used as a low calorie sweetener as it is poorly absorbed by the intestines. As a medication, it is used to decrease pressure in the eyes, as in glaucoma, and to lower increased intracranial pressure. Medically, it is given by injection or inhalation. Effects typically begin within 15 minutes and last up to 8 hours.
Common side effects from medical use include electrolyte problems and dehydration. Other serious side effects may include worsening heart failure and kidney problems. It is unclear if use is safe in pregnancy. Mannitol is in the osmotic diuretic family of medications and works by pulling fluid from the brain and eyes.
The discovery of mannitol is attributed to Joseph Louis Proust in 1806. It is on the World Health Organization's List of Essential Medicines. It was originally made from the flowering ash and called manna due to its supposed resemblance to the Biblical food. Mannitol is on the World Anti-Doping Agency's banned substances list due to concerns that it may mask prohibited drugs. |
|
Read full article at Wikipedia
|
InChI=1S/C53H83NO14/c1- 32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1 |
| HKVAMNSJSFKALM-GKUWKFKPSA-N |
| [H][C@]1(CC[C@@H](OCCO)[C@@H](C1)OC)C[C@@H](C)[C@]1([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]2([H])CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@@]2([H])C(=O)O1)OC |
|
|
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
mTOR inhibitor
A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer.
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
|
|
|
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
geroprotector
Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
|
|
View more via ChEBI Ontology
|
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
|
évérolimus
|
WHO MedNet
|
|
everolimus
|
WHO MedNet
|
everolimus
|
WHO MedNet
|
everolimusum
|
WHO MedNet
|
|
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1,18-dihydroxy-12-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
|
IUPAC
|
|
40-O-(2-hydroxyethyl)-rapamycin
|
ChemIDplus
|
|
42-O-(2-hydroxyethyl)rapamycin
|
ChemIDplus
|
|
Everolimus
|
ChemIDplus
|
|
RAD 001
|
ChemIDplus
|
|
RAD001
|
ChemIDplus
|
|
SDZ RAD
|
ChemIDplus
|
|
SDZ-RAD
|
ChemIDplus
|
|
Afinitor
|
ChemIDplus
|
|
Afinitor Disperz
|
ChemIDplus
|
|
Certican
|
ChemIDplus
|
|
Votubia
|
DrugCentral
|
|
Xience V
|
ChemIDplus
|
|
Zortress
|
ChemIDplus
|
|
159351-69-6
|
CAS Registry Number
|
ChemIDplus
|
|
22363408
|
PubMed citation
|
Europe PMC
|
|
22404500
|
PubMed citation
|
Europe PMC
|
|
22461124
|
PubMed citation
|
Europe PMC
|
|
22683823
|
PubMed citation
|
Europe PMC
|
|
22967800
|
PubMed citation
|
Europe PMC
|
|
22969095
|
PubMed citation
|
Europe PMC
|
|
22983698
|
PubMed citation
|
Europe PMC
|
|
22986894
|
PubMed citation
|
Europe PMC
|
|
31478889
|
PubMed citation
|
Europe PMC
|
|
33640871
|
PubMed citation
|
Europe PMC
|
|
33986025
|
PubMed citation
|
Europe PMC
|
|
33998365
|
PubMed citation
|
Europe PMC
|
|
34018490
|
PubMed citation
|
Europe PMC
|
|
34225066
|
PubMed citation
|
Europe PMC
|
|
34242751
|
PubMed citation
|
Europe PMC
|
|
34253597
|
PubMed citation
|
Europe PMC
|
|
34299359
|
PubMed citation
|
Europe PMC
|
|
34467233
|
PubMed citation
|
Europe PMC
|
|
34491881
|
PubMed citation
|
Europe PMC
|
|
34527569
|
PubMed citation
|
Europe PMC
|
|
