miconazole |
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CHEBI:6923 |
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A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes. |
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This entity has been manually annotated by the ChEBI Team.
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CHEBI:108917
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Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina. It is used for ring worm of the body, groin (jock itch), and feet (athlete's foot). It is applied to the skin or vagina as a cream or ointment.
Common side effects include itchiness or irritation of the area in which it was applied. Use in pregnancy is believed to be safe for the baby. Miconazole is in the imidazole family of medications. It works by decreasing the ability of fungi to make ergosterol, an important part of their cell membrane.
Miconazole was patented in 1968 and approved for medical use in 1971. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. |
Read full article at Wikipedia
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ergosterol biosynthesis inhibitor
Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol.
(via conazole antifungal agent )
glucocorticoid receptor antagonist
An antagonist that binds to and deactivates glucocorticoid receptors.
antifungal drug
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
(via imidazole antifungal drug )
(via conazole antifungal drug )
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
(via imidazole antifungal agent )
(via conazole antifungal agent )
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antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
antifungal drug
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
(via imidazole antifungal drug )
(via conazole antifungal drug )
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View more via ChEBI Ontology
rac-1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
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(±)-miconazole
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ChEBI
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(RS)-miconazole
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ChEBI
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1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
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ChemIDplus
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1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
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ChEMBL
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Daktarin IV
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ChemIDplus
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Miconazole
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KEGG DRUG
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Monistat IV (TN)
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KEGG DRUG
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rac-miconazole
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ChEBI
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22916-47-8
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CAS Registry Number
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KEGG DRUG
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22916-47-8
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CAS Registry Number
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ChemIDplus
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965511
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Reaxys Registry Number
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Reaxys
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11922774
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