CHEBI:71417 - procarbazine

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ChEBI Name procarbazine ChEBI ID CHEBI:71417 Definition A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands. Stars This entity has been manually annotated by the ChEBI Team. Submitter Anonymous Secondary ChEBI IDs CHEBI:8432 Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C12H19N3O Net Charge 0 Average Mass 221.29880 Monoisotopic Mass 221.15281 InChI InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16) InChIKey CPTBDICYNRMXFX-UHFFFAOYSA-N SMILES CNNCc1ccc(cc1)C(=O)NC(C)C Roles Classification Application(s): antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. View more via ChEBI Ontology ChEBI Ontology Outgoing procarbazine (CHEBI:71417) has role antineoplastic agent (CHEBI:35610) procarbazine (CHEBI:71417) is a benzamides (CHEBI:22702) procarbazine (CHEBI:71417) is a hydrazines (CHEBI:24631) procarbazine (CHEBI:71417) is conjugate base of procarbazine(1+) (CHEBI:71431) Incoming procarbazine(1+) (CHEBI:71431) is conjugate acid of procarbazine (CHEBI:71417) IUPAC Name N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide INNs Sources procarbazina DrugBank procarbazine WHO MedNet procarbazine KEGG DRUG procarbazinum DrugBank Synonyms Sources 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine ChemIDplus 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine ChemIDplus 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide ChemIDplus N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide ChemIDplus N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine ChemIDplus N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide IUPAC N-Isopropyl-α-(2-methylhydrazino)-p-toluamide NIST Chemistry WebBook N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide ChemIDplus p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide NIST Chemistry WebBook Procarbazin DrugBank Manual Xrefs Databases 2272 DrugCentral BE618638 Patent C07402 KEGG COMPOUND D08423 KEGG DRUG DB01168 DrugBank HMDB0015299 HMDB LSM-2272 LINCS Procarbazine Wikipedia US2007122414 Patent US2008107661 Patent US3520926 Patent US3830840 Patent View more database links Registry Numbers Types Sources 671-16-9 CAS Registry Number KEGG COMPOUND 671-16-9 CAS Registry Number ChemIDplus 671-16-9 CAS Registry Number NIST Chemistry WebBook 958270 Reaxys Registry Number Reaxys Citations Types Sources 21420247 PubMed citation Europe PMC 21703849 PubMed citation Europe PMC 21740300 PubMed citation Europe PMC 21870118 PubMed citation Europe PMC 22423248 PubMed citation Europe PMC 22708037 PubMed citation Europe PMC 22744756 PubMed citation Europe PMC 22851558 PubMed citation Europe PMC 22913972 PubMed citation Europe PMC 23071237 PubMed citation Europe PMC Last Modified 22 February 2017