CHEBI:7939 - parthenolide

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name parthenolide
ChEBI ID CHEBI:7939
Definition A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information eMolecules:31240803, ZINC000004492886
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C15H20O3
Net Charge 0
Average Mass 248.31750
Monoisotopic Mass 248.14124
InChI InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
InChIKey KTEXNACQROZXEV-PVLRGYAZSA-N
SMILES [H][C@@]12CC\C(C)=C\CC[C@@]3(C)O[C@]3([H])[C@@]1([H])OC(=O)C2=C
Roles Classification
Biological Role(s): drug allergen
Any drug which causes the onset of an allergic reaction.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
inhibitor
A substance that diminishes the rate of a chemical reaction.
Application(s): drug allergen
Any drug which causes the onset of an allergic reaction.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
peripheral nervous system drug
A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing parthenolide (CHEBI:7939) has role drug allergen (CHEBI:88188)
parthenolide (CHEBI:7939) has role inhibitor (CHEBI:35222)
parthenolide (CHEBI:7939) has role non-narcotic analgesic (CHEBI:35481)
parthenolide (CHEBI:7939) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
parthenolide (CHEBI:7939) has role peripheral nervous system drug (CHEBI:49110)
parthenolide (CHEBI:7939) is a sesquiterpene lactone (CHEBI:37667)
Incoming 3β-hydroxyparthenolide (CHEBI:144561) has functional parent parthenolide (CHEBI:7939)
IUPAC Name
(1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Synonyms Sources
(-)-Parthenolide ChemIDplus
4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone ChemIDplus
parthenolide UniProt
Parthenolide KEGG COMPOUND
Manual Xrefs Databases
C00003345 KNApSAcK
C07609 KEGG COMPOUND
LMPR0103090002 LIPID MAPS
Parthenolide Wikipedia
View more database links
Registry Numbers Types Sources
20554-84-1 CAS Registry Number KEGG COMPOUND
20554-84-1 CAS Registry Number ChemIDplus
3550011 Reaxys Registry Number Reaxys
Citations Waiting for Citations
Last Modified
18 August 2019