KN-93 (CHEBI:91460)

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ChEBI Name	KN-93

ChEBI ID	CHEBI:91460

Definition	A sulfonamide resulting from the formal condensation of p-methoxybenzenesulfonic acid with the anilino nitrogen of 2-(aminomethyl)-N-(2-hydroxyethyl)aniline in which the hydrogens of the primary amino group have been replaced by methyl and p-chlorocinnamyl groups. KN-93 is a selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II.

Stars	This entity has been manually annotated by the ChEBI Team.

Download	Molfile XML SDF

Formula

C26H29ClN2O4S

Net Charge

Average Mass

501.039

Monoisotopic Mass

500.15366

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor Any EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of a Ca2+/calmodulin-dependent protein kinase (EC 2.7.11.17).

Application(s):	geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.

ChEBI Ontology
Outgoing	KN-93 (CHEBI:91460) has role EC 2.7.11.17 (Ca²⁺/calmodulin-dependent protein kinase) inhibitor (CHEBI:131794) KN-93 (CHEBI:91460) has role geroprotector (CHEBI:176497) KN-93 (CHEBI:91460) is a monochlorobenzenes (CHEBI:83403) KN-93 (CHEBI:91460) is a monomethoxybenzene (CHEBI:25235) KN-93 (CHEBI:91460) is a primary alcohol (CHEBI:15734) KN-93 (CHEBI:91460) is a sulfonamide (CHEBI:35358) KN-93 (CHEBI:91460) is a tertiary amino compound (CHEBI:50996)

IUPAC Name

N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide

Synonyms	Sources
KN 93	ChemIDplus
KN93	ChEBI
N-[2-[[3-(4-chlorophenyl)prop-2-enyl-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide	LINCS

Last Modified

26 October 2021