AmiGO 2: Term Details for "phosphoprotein phosphatase activity" (GO:0004721)

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Term Information

Accession: GO:0004721
Name: phosphoprotein phosphatase activity
Ontology: molecular_function
Synonyms: phosphoprotein phosphohydrolase activity, protein phosphatase activity, protein phosphatase-1 activity, protein phosphatase-2A activity, protein phosphatase-2B activity, protein phosphatase-2C activity
Alternate IDs: None
Definition: Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. Source: ISBN:0198547684
Comment: None
History: See term history for GO:0004721 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to phosphoprotein phosphatase activity (excluding "regulates").; Link to all direct and indirect annotations to phosphoprotein phosphatase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for phosphoprotein phosphatase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0003674 molecular_function
GO:0042578 phosphoric ester hydrolase activity
GO:0140096 catalytic activity, acting on a protein
GO:0016791 phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0047385 [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
GO:0050406 [acetyl-CoA carboxylase]-phosphatase activity
GO:0050407 [glycogen-synthase-D] phosphatase activity
GO:0047384 [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity
GO:0101014 [isocitrate dehydrogenase (NADP+)] phosphatase activity
GO:0050196 [phosphorylase] phosphatase activity
GO:0050408 [pyruvate kinase]-phosphatase activity
GO:0140789 histone phosphatase activity
GO:0033549 MAP kinase phosphatase activity
GO:0050115 myosin-light-chain-phosphatase activity
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0098627 protein arginine phosphatase activity
GO:0101006 protein histidine phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0019198 transmembrane receptor protein phosphatase activity

Parents of phosphoprotein phosphatase activity (GO:0004721)

subject	relation	object
phosphoprotein phosphatase activity	is_a	phosphatase activity (GO:0016791)
phosphoprotein phosphatase activity	is_a	catalytic activity, acting on a protein (GO:0140096)

Children of phosphoprotein phosphatase activity (GO:0004721)

subject	relation	object
negative regulation of phosphoprotein phosphatase activity (GO:0032515)	RO:0002212	phosphoprotein phosphatase activity
protein tyrosine/threonine phosphatase activity (GO:0008330)	is_a	phosphoprotein phosphatase activity
protein phosphatase activator activity (GO:0072542)	RO:0002629	phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity (GO:0004722)	is_a	phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity (GO:0032516)	RO:0002213	phosphoprotein phosphatase activity
MAP kinase phosphatase activity (GO:0033549)	is_a	phosphoprotein phosphatase activity
protein tyrosine phosphatase activity (GO:0004725)	is_a	phosphoprotein phosphatase activity
protein arginine phosphatase activity (GO:0098627)	is_a	phosphoprotein phosphatase activity
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity (GO:0047385)	is_a	phosphoprotein phosphatase activity
[isocitrate dehydrogenase (NADP+)] phosphatase activity (GO:0101014)	is_a	phosphoprotein phosphatase activity
protein histidine phosphatase activity (GO:0101006)	is_a	phosphoprotein phosphatase activity
histone phosphatase activity (GO:0140789)	is_a	phosphoprotein phosphatase activity
[phosphorylase] phosphatase activity (GO:0050196)	is_a	phosphoprotein phosphatase activity
[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity (GO:0047384)	is_a	phosphoprotein phosphatase activity
[pyruvate kinase]-phosphatase activity (GO:0050408)	is_a	phosphoprotein phosphatase activity
myosin-light-chain-phosphatase activity (GO:0050115)	is_a	phosphoprotein phosphatase activity
protein phosphatase regulator activity (GO:0019888)	RO:0002578	phosphoprotein phosphatase activity
protein phosphatase inhibitor activity (GO:0004864)	RO:0002630	phosphoprotein phosphatase activity
[glycogen-synthase-D] phosphatase activity (GO:0050407)	is_a	phosphoprotein phosphatase activity
protein tyrosine/serine/threonine phosphatase activity (GO:0008138)	is_a	phosphoprotein phosphatase activity
regulation of phosphoprotein phosphatase activity (GO:0043666)	RO:0002211	phosphoprotein phosphatase activity
transmembrane receptor protein phosphatase activity (GO:0019198)	is_a	phosphoprotein phosphatase activity
[acetyl-CoA carboxylase]-phosphatase activity (GO:0050406)	is_a	phosphoprotein phosphatase activity

Reactome: R-HSA-167072; R-HSA-112383; R-HSA-69199; R-HSA-1363274; R-HSA-170158; R-HSA-1363276; R-HSA-9636684; R-HSA-178178; R-HSA-174110; R-HSA-2529015; R-HSA-170161; R-HSA-170153; R-HSA-113503; R-HSA-174124