obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process
Ontology
biological_process
Synonyms
caspase activation, activation of caspase activity, activation of metacaspase activity
Alternate IDs
None
Definition
OBSOLETE. Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
Source:
GOC:al,
GOC:dph,
GOC:tb,
PMID:18328827,
GOC:jl,
PMID:14744432,
Wikipedia:Caspase,
GOC:mtg_apoptosis
Comment
This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
The reason for obsoletion is that this term represents a GO-CAM model.
Link
to all genes and gene products annotated to obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process (excluding "regulates").
Link
to all direct and indirect annotations
to obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process (excluding "regulates").
Link
to all direct and indirect annotations download (limited to first 10,000)
for obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process (excluding "regulates").
