AmiGO 2: Term Details for "extrinsic apoptotic signaling pathway via death domain receptors" (GO:0008625)

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Term Information

Accession: GO:0008625
Name: extrinsic apoptotic signaling pathway via death domain receptors
Ontology: biological_process
Synonyms: induction of apoptosis via death receptors, induction of apoptosis via death domain receptors, death receptor-mediated apoptosis
Alternate IDs: None
Definition: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. Source: GOC:mah, GOC:mtg_apoptosis
Comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
History: See term history for GO:0008625 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to extrinsic apoptotic signaling pathway via death domain receptors (excluding "regulates").; Link to all direct and indirect annotations to extrinsic apoptotic signaling pathway via death domain receptors (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for extrinsic apoptotic signaling pathway via death domain receptors (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0008219 cell death
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0012501 programmed cell death
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0097190 apoptotic signaling pathway
GO:0007166 cell surface receptor signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0036462 TRAIL-activated apoptotic signaling pathway

Parents of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)

subject	relation	object
extrinsic apoptotic signaling pathway via death domain receptors	RO:0002162	Opisthokonta (NCBITaxon:33154)
extrinsic apoptotic signaling pathway via death domain receptors	is_a	extrinsic apoptotic signaling pathway (GO:0097191)

Children of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)

subject	relation	object
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	RO:0002212	extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	RO:0002213	extrinsic apoptotic signaling pathway via death domain receptors
TRAIL-activated apoptotic signaling pathway (GO:0036462)	is_a	extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	RO:0002211	extrinsic apoptotic signaling pathway via death domain receptors

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